GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

STX5 (syntaxin 5)

Gene

6811

Syntaxin 5

STX5

CDG2AA, SED5, STX5A

11q12.3

This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The en

Show/Hide all(125)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021024	hsa-miR-155-5p	Proteomics	18668040
MIRT1401051	hsa-miR-3163	CLIP-seq
MIRT1401052	hsa-miR-3681	CLIP-seq
MIRT1401053	hsa-miR-4261	CLIP-seq
MIRT1401054	hsa-miR-548c-3p	CLIP-seq
MIRT2120251	hsa-miR-3121-5p	CLIP-seq
MIRT2120252	hsa-miR-3122	CLIP-seq
MIRT2120253	hsa-miR-3135b	CLIP-seq
MIRT2120254	hsa-miR-3652	CLIP-seq
MIRT2120255	hsa-miR-3689a-3p	CLIP-seq
MIRT2120256	hsa-miR-3689c	CLIP-seq
MIRT2120257	hsa-miR-3913-5p	CLIP-seq
MIRT2120258	hsa-miR-3918	CLIP-seq
MIRT1401053	hsa-miR-4261	CLIP-seq
MIRT2120259	hsa-miR-4430	CLIP-seq
MIRT2120260	hsa-miR-4512	CLIP-seq
MIRT2120261	hsa-miR-4685-5p	CLIP-seq
MIRT2120262	hsa-miR-485-5p	CLIP-seq
MIRT2120263	hsa-miR-513a-5p	CLIP-seq
MIRT2120264	hsa-miR-516a-3p	CLIP-seq
MIRT2342273	hsa-miR-103a	CLIP-seq
MIRT2342274	hsa-miR-107	CLIP-seq
MIRT2342275	hsa-miR-10a	CLIP-seq
MIRT2342276	hsa-miR-10b	CLIP-seq
MIRT2342277	hsa-miR-1184	CLIP-seq
MIRT2342278	hsa-miR-1226	CLIP-seq
MIRT2342279	hsa-miR-1266	CLIP-seq
MIRT2342280	hsa-miR-1271	CLIP-seq
MIRT2342281	hsa-miR-182	CLIP-seq
MIRT2342282	hsa-miR-24	CLIP-seq
MIRT2342283	hsa-miR-3127-5p	CLIP-seq
MIRT2342284	hsa-miR-3179	CLIP-seq
MIRT2120255	hsa-miR-3689a-3p	CLIP-seq
MIRT2120256	hsa-miR-3689c	CLIP-seq
MIRT2120258	hsa-miR-3918	CLIP-seq
MIRT2342285	hsa-miR-4437	CLIP-seq
MIRT2342286	hsa-miR-4514	CLIP-seq
MIRT2342287	hsa-miR-4518	CLIP-seq
MIRT2342288	hsa-miR-4530	CLIP-seq
MIRT2342289	hsa-miR-4692	CLIP-seq
MIRT2342290	hsa-miR-4717-3p	CLIP-seq
MIRT2342291	hsa-miR-4733-3p	CLIP-seq
MIRT2120262	hsa-miR-485-5p	CLIP-seq
MIRT2342292	hsa-miR-548ad	CLIP-seq
MIRT2342293	hsa-miR-558	CLIP-seq
MIRT2342294	hsa-miR-627	CLIP-seq
MIRT2342295	hsa-miR-634	CLIP-seq
MIRT2342296	hsa-miR-96	CLIP-seq
MIRT2395387	hsa-miR-3125	CLIP-seq
MIRT2395388	hsa-miR-3916	CLIP-seq
MIRT2342290	hsa-miR-4717-3p	CLIP-seq
MIRT2395389	hsa-miR-583	CLIP-seq
MIRT1401051	hsa-miR-3163	CLIP-seq
MIRT2460761	hsa-miR-340	CLIP-seq
MIRT1401054	hsa-miR-548c-3p	CLIP-seq
MIRT2460762	hsa-miR-629	CLIP-seq
MIRT2342273	hsa-miR-103a	CLIP-seq
MIRT2342274	hsa-miR-107	CLIP-seq
MIRT2342277	hsa-miR-1184	CLIP-seq
MIRT2342278	hsa-miR-1226	CLIP-seq
MIRT2342280	hsa-miR-1271	CLIP-seq
MIRT2342281	hsa-miR-182	CLIP-seq
MIRT2636050	hsa-miR-185	CLIP-seq
MIRT2636051	hsa-miR-204	CLIP-seq
MIRT2636052	hsa-miR-211	CLIP-seq
MIRT2120251	hsa-miR-3121-5p	CLIP-seq
MIRT2120252	hsa-miR-3122	CLIP-seq
MIRT2120253	hsa-miR-3135b	CLIP-seq
MIRT1401051	hsa-miR-3163	CLIP-seq
MIRT2460761	hsa-miR-340	CLIP-seq
MIRT2120254	hsa-miR-3652	CLIP-seq
MIRT1401052	hsa-miR-3681	CLIP-seq
MIRT2120255	hsa-miR-3689a-3p	CLIP-seq
MIRT2120256	hsa-miR-3689c	CLIP-seq
MIRT2120257	hsa-miR-3913-5p	CLIP-seq
MIRT2636053	hsa-miR-4287	CLIP-seq
MIRT2636054	hsa-miR-4306	CLIP-seq
MIRT2636055	hsa-miR-431	CLIP-seq
MIRT2120259	hsa-miR-4430	CLIP-seq
MIRT2636056	hsa-miR-4469	CLIP-seq
MIRT2636057	hsa-miR-4476	CLIP-seq
MIRT2342288	hsa-miR-4530	CLIP-seq
MIRT2636058	hsa-miR-4644	CLIP-seq
MIRT2636059	hsa-miR-4645-3p	CLIP-seq
MIRT2636060	hsa-miR-4685-3p	CLIP-seq
MIRT2636061	hsa-miR-4718	CLIP-seq
MIRT2342291	hsa-miR-4733-3p	CLIP-seq
MIRT2636062	hsa-miR-4761-3p	CLIP-seq
MIRT2120262	hsa-miR-485-5p	CLIP-seq
MIRT2120263	hsa-miR-513a-5p	CLIP-seq
MIRT2120264	hsa-miR-516a-3p	CLIP-seq
MIRT2342292	hsa-miR-548ad	CLIP-seq
MIRT1401054	hsa-miR-548c-3p	CLIP-seq
MIRT2636063	hsa-miR-555	CLIP-seq
MIRT2342293	hsa-miR-558	CLIP-seq
MIRT2342294	hsa-miR-627	CLIP-seq
MIRT2460762	hsa-miR-629	CLIP-seq
MIRT2342295	hsa-miR-634	CLIP-seq
MIRT2342296	hsa-miR-96	CLIP-seq
MIRT2636050	hsa-miR-185	CLIP-seq
MIRT2636051	hsa-miR-204	CLIP-seq
MIRT2636052	hsa-miR-211	CLIP-seq
MIRT2120251	hsa-miR-3121-5p	CLIP-seq
MIRT2120252	hsa-miR-3122	CLIP-seq
MIRT2120253	hsa-miR-3135b	CLIP-seq
MIRT1401051	hsa-miR-3163	CLIP-seq
MIRT2460761	hsa-miR-340	CLIP-seq
MIRT2120254	hsa-miR-3652	CLIP-seq
MIRT2120255	hsa-miR-3689a-3p	CLIP-seq
MIRT2120256	hsa-miR-3689c	CLIP-seq
MIRT2120257	hsa-miR-3913-5p	CLIP-seq
MIRT2636053	hsa-miR-4287	CLIP-seq
MIRT2636054	hsa-miR-4306	CLIP-seq
MIRT2120259	hsa-miR-4430	CLIP-seq
MIRT2636056	hsa-miR-4469	CLIP-seq
MIRT2636057	hsa-miR-4476	CLIP-seq
MIRT2636058	hsa-miR-4644	CLIP-seq
MIRT2636060	hsa-miR-4685-3p	CLIP-seq
MIRT2636062	hsa-miR-4761-3p	CLIP-seq
MIRT2120262	hsa-miR-485-5p	CLIP-seq
MIRT2120263	hsa-miR-513a-5p	CLIP-seq
MIRT2120264	hsa-miR-516a-3p	CLIP-seq
MIRT1401054	hsa-miR-548c-3p	CLIP-seq
MIRT2636063	hsa-miR-555	CLIP-seq
MIRT2460762	hsa-miR-629	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA	21873635
GO:0000139	Component	Golgi membrane	TAS
GO:0000149	Function	SNARE binding	IBA	21873635
GO:0005484	Function	SNAP receptor activity	IBA	21873635
GO:0005484	Function	SNAP receptor activity	IDA	15215310
GO:0005515	Function	Protein binding	IPI	18167358, 18843296, 19536132, 25416956, 25910212, 30833792, 32296183, 32814053
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005794	Component	Golgi apparatus	IDA	9464276, 15215310, 16081076
GO:0005829	Component	Cytosol	IEA
GO:0006886	Process	Intracellular protein transport	IBA	21873635
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA	21873635
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
GO:0006906	Process	Vesicle fusion	IBA	21873635
GO:0012505	Component	Endomembrane system	IBA	21873635
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0031201	Component	SNARE complex	IBA	21873635
GO:0031201	Component	SNARE complex	TAS	15215310
GO:0031982	Component	Vesicle	IDA	16081076
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	TAS
GO:0034498	Process	Early endosome to Golgi transport	IMP	17389686
GO:0042147	Process	Retrograde transport, endosome to Golgi	IDA	15215310
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045732	Process	Positive regulation of protein catabolic process	IMP	21242315
GO:0047485	Function	Protein N-terminus binding	IPI	19536132
GO:0048208	Process	COPII vesicle coating	TAS
GO:0048278	Process	Vesicle docking	IBA	21873635
GO:0048280	Process	Vesicle fusion with Golgi apparatus	IEA
GO:0090166	Process	Golgi disassembly	IDA	16081076
GO:1903358	Process	Regulation of Golgi organization	IDA	16081076

MIM	HGNC	e!Ensembl
603189	11440	ENSG00000162236

Protein

UniProt ID

Q13190

Protein name

Syntaxin-5

Protein function

Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. {ECO:00

PDB

3EFO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11416	Syntaxin-5_N	52 → 74	Syntaxin-5 N-terminal, Sly1p-binding domain	Family
PF05739	SNARE	299 → 351	SNARE domain	Family

Sequence

MIPRKRYGSKNTDQGVYLGLSKTQVLSPATAGSSSSDIAPLPPPVTLVPPPPDTMSCRDR
TQEFLSACKSLQTRQNGIQTNKPALRAVRQRSEFTLMAKRIGKDLSNTFAKLEKLTILAK
RKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQDFVRAKGSQSGRHLQTHSNTIVVSLQ
SKLASMSNDFKSVLEVRTENLKQQRSRREQFSRAPVSALPLAPNHLGGGAVVLGAESHAS
KDVAIDMMDSRTSQQLQLIDEQDSYIQSRADTMQNIESTIVELGSIFQQLAHMVKEQEET
IQRIDENVLGAQLDVEAAHSEILKYFQSVTSNRWLMVKIFLILIVFFIIFVVFLA

Sequence length

355

Interactions

View interactions

	KEGG		Reactome
	SNARE interactions in vesicular transport		COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412