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STAU1 (staufen double-stranded RNA binding protein 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6780
Gene nameGene Name - the full gene name approved by the HGNC.
Staufen double-stranded RNA binding protein 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
STAU1
SynonymsGene synonyms aliases
PPP1R150, STAU
ChromosomeChromosome number
20
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q13.13
SummarySummary of gene provided in NCBI Entrez Gene.
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021842 hsa-miR-132-3p Microarray 17612493
MIRT028692 hsa-miR-27a-3p Sequencing 20371350
MIRT031669 hsa-miR-16-5p Proteomics 18668040
MIRT044157 hsa-miR-30e-5p CLASH 23622248
MIRT037250 hsa-miR-877-5p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22681889
GO:0003725 Function Double-stranded RNA binding IEA
GO:0005515 Function Protein binding IPI 15121898, 15303970, 15680326, 19029303, 20064372, 22810585, 22978549, 23722113, 23853584, 25416956, 26045787, 28169297, 32296183
GO:0005737 Component Cytoplasm IDA 19029303, 22978549
GO:0005783 Component Endoplasmic reticulum IDA 23907398
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O95793
Protein name Double-stranded RNA-binding protein Staufen homolog 1
Protein function Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.;
PDB 4DKK , 6HTU , 6SDW , 6SDY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00035 dsrm
76 160
Double-stranded RNA binding motif
Domain
PF00035 dsrm
185 249
Double-stranded RNA binding motif
Domain
PF00035 dsrm
287 352
Double-stranded RNA binding motif
Domain
PF16482 Staufen_C
446 557
Staufen C-terminal domain
Domain
Sequence
MSQVQVQVQNPSAALSGSQILNKNQSLLSQPLMSIPSTTSSLPSENAGRPIQNSALPSAS
ITSTSAAAESITPTVELNALCMKLGKKPMYKPVDPYSRMQSTYNYNMRGGAYPPRYFYPF
PVPPLLYQVELSVGGQQFNGKGKTRQAAKHDAAAKALRIL
QNEPLPERLEVNGRESEEEN
LNKSEISQVFEIALKRNLPVNFEVARESGPPHMKNFVTKVSVGEFVGEGEGKSKKISKKN
AAIAVLEEL
KKLPPLPAVERVKPRIKKKTKPIVKPQTSPEYGQGINPISRLAQIQQAKKE
KEPEYTLLTERGLPRRREFVMQVKVGNHTAEGTGTNKKVAKRNAAENMLEIL
GFKVPQAQ
PTKPALKSEEKTPIKKPGDGRKVTFFEPGSGDENGTSNKEDEFRMPYLSHQQLPAGILPM
VPEVAQAVGVSQGHHTKDFTRAAPNPAKATVTAMIARELLYGGTSPTAETILKNNISSGH
VPHGPLTRPSEQLDYLSRVQGFQVEYKDFPKNNKNEFVSLINCSSQPPLISHGIGKDVES
CHDMAALNILKLLSELD
QQSTEMPRTGNGPMSVCGRC
Sequence length 577
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 31374203
Unknown
Disease name Disease term dbSNP ID References
Mental depression Major Depressive Disorder rs587778876, rs587778877 29942085

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