Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
6780 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Staufen double-stranded RNA binding protein 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
STAU1 |
SynonymsGene synonyms aliases
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PPP1R150, STAU |
ChromosomeChromosome number
|
20 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
20q13.13 |
SummarySummary of gene provided in NCBI Entrez Gene.
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Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple |
miRNAmiRNA information provided by mirtarbase database.
|
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0003723 |
Function |
RNA binding |
HDA |
22681889 |
GO:0003725 |
Function |
Double-stranded RNA binding |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
15121898, 15303970, 15680326, 19029303, 20064372, 22810585, 22978549, 23722113, 23853584, 25416956, 26045787, 28169297, 32296183 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
19029303, 22978549 |
GO:0005783 |
Component |
Endoplasmic reticulum |
IDA |
23907398 |
GO:0005791 |
Component |
Rough endoplasmic reticulum |
IEA |
|
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0005875 |
Component |
Microtubule associated complex |
TAS |
10022909 |
GO:0005886 |
Component |
Plasma membrane |
IDA |
22978549 |
GO:0008157 |
Function |
Protein phosphatase 1 binding |
IEA |
|
GO:0010494 |
Component |
Cytoplasmic stress granule |
ISS |
|
GO:0016020 |
Component |
Membrane |
HDA |
19946888 |
GO:0016032 |
Process |
Viral process |
IEA |
|
GO:0030425 |
Component |
Dendrite |
IDA |
15121898 |
GO:0034599 |
Process |
Cellular response to oxidative stress |
IEA |
|
GO:0036464 |
Component |
Cytoplasmic ribonucleoprotein granule |
IDA |
15121898 |
GO:0043025 |
Component |
Neuronal cell body |
IEA |
|
GO:0044297 |
Component |
Cell body |
IDA |
15121898 |
GO:0045070 |
Process |
Positive regulation of viral genome replication |
IMP |
23907398 |
GO:0046726 |
Process |
Positive regulation by virus of viral protein levels in host cell |
IMP |
23907398 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19199708 |
GO:0098978 |
Component |
Glutamatergic synapse |
IEA |
|
GO:0099010 |
Process |
Modification of postsynaptic structure |
IEA |
|
GO:1900273 |
Process |
Positive regulation of long-term synaptic potentiation |
IEA |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
O95793 |
Protein name |
Double-stranded RNA-binding protein Staufen homolog 1 |
Protein function |
Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.; |
PDB |
4DKK
,
6HTU
,
6SDW
,
6SDY
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00035 |
dsrm |
76 → 160 |
Double-stranded RNA binding motif |
Domain |
PF00035 |
dsrm |
185 → 249 |
Double-stranded RNA binding motif |
Domain |
PF00035 |
dsrm |
287 → 352 |
Double-stranded RNA binding motif |
Domain |
PF16482 |
Staufen_C |
446 → 557 |
Staufen C-terminal domain |
Domain |
|
Sequence |
|
Sequence length |
577 |
Interactions |
View interactions |
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
31374203 |
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