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STAT5B (signal transducer and activator of transcription 5B)

Gene

6777

Signal transducer and activator of transcription 5B

STAT5B

GHISID2, STAT5

17q21.2

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that tran

Show/Hide all(9)

SNP ID	Visualize variation	Clinical significance	Consequence
rs121908501	C>G	Pathogenic	Coding sequence variant, missense variant, genic downstream transcript variant
rs121908502	G>A	Pathogenic	Coding sequence variant, stop gained
rs143171571	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs143172354	C>G,T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant, genic downstream transcript variant
rs148793995	C>G	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs761761205	G>-,GG	Pathogenic	Coding sequence variant, frameshift variant
rs1555548678	G>A	Pathogenic	Coding sequence variant, missense variant
rs1555548680	T>C	Pathogenic	Coding sequence variant, missense variant
rs1555549674	T>G	Pathogenic	Coding sequence variant, missense variant

Show/Hide all(273)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023476	hsa-miR-23b-3p	Sequencing	20371350
MIRT042849	hsa-miR-324-3p	CLASH	23622248
MIRT038811	hsa-miR-93-3p	CLASH	23622248
MIRT036362	hsa-miR-1229-3p	CLASH	23622248
MIRT054842	hsa-miR-134-5p	Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot	24440911
MIRT635719	hsa-miR-8485	HITS-CLIP	23313552
MIRT635718	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT287194	hsa-miR-19a-3p	HITS-CLIP	23313552
MIRT287195	hsa-miR-19b-3p	HITS-CLIP	23313552
MIRT635718	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT635719	hsa-miR-8485	HITS-CLIP	23824327
MIRT635718	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT635719	hsa-miR-8485	HITS-CLIP	23824327
MIRT635718	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT635719	hsa-miR-8485	HITS-CLIP	23824327
MIRT635719	hsa-miR-8485	HITS-CLIP	23824327
MIRT635718	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT635719	hsa-miR-8485	HITS-CLIP	23824327
MIRT635718	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT635719	hsa-miR-8485	HITS-CLIP	23824327
MIRT635718	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT635719	hsa-miR-8485	HITS-CLIP	23824327
MIRT635718	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT648654	hsa-miR-106b-3p	HITS-CLIP	23824327
MIRT635719	hsa-miR-8485	HITS-CLIP	23824327
MIRT635718	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT497821	hsa-miR-4762-5p	PAR-CLIP	22291592
MIRT497820	hsa-miR-3184-5p	PAR-CLIP	22291592
MIRT497819	hsa-miR-423-5p	PAR-CLIP	22291592
MIRT497818	hsa-miR-1914-3p	PAR-CLIP	22291592
MIRT497817	hsa-miR-5194	PAR-CLIP	22291592
MIRT497816	hsa-miR-6738-5p	PAR-CLIP	22291592
MIRT497815	hsa-miR-526b-5p	PAR-CLIP	22291592
MIRT497814	hsa-miR-6834-5p	PAR-CLIP	22291592
MIRT497813	hsa-miR-1226-5p	PAR-CLIP	22291592
MIRT497812	hsa-miR-6734-5p	PAR-CLIP	22291592
MIRT497811	hsa-miR-335-3p	PAR-CLIP	22291592
MIRT732355	hsa-miR-150-5p	Luciferase reporter assay, qRT-PCR, Western blot	27447965
MIRT732355	hsa-miR-150-5p	Luciferase reporter assay, qRT-PCR, Western blot	27447965
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT575421	hsa-miR-8485	HITS-CLIP	27418678
MIRT575421	hsa-miR-8485	HITS-CLIP	27418678
MIRT575421	hsa-miR-8485	HITS-CLIP	27418678
MIRT735577	hsa-miR-5094	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	32127949
MIRT575421	hsa-miR-8485	HITS-CLIP	23313552
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT287194	hsa-miR-19a-3p	HITS-CLIP	23313552
MIRT287195	hsa-miR-19b-3p	HITS-CLIP	23313552
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT575421	hsa-miR-8485	HITS-CLIP	23824327
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT575421	hsa-miR-8485	HITS-CLIP	23824327
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT575421	hsa-miR-8485	HITS-CLIP	23824327
MIRT575421	hsa-miR-8485	HITS-CLIP	23824327
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT575421	hsa-miR-8485	HITS-CLIP	23824327
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT575421	hsa-miR-8485	HITS-CLIP	23824327
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT575421	hsa-miR-8485	HITS-CLIP	23824327
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT648654	hsa-miR-106b-3p	HITS-CLIP	23824327
MIRT575421	hsa-miR-8485	HITS-CLIP	23824327
MIRT575420	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT497821	hsa-miR-4762-5p	PAR-CLIP	22291592
MIRT497820	hsa-miR-3184-5p	PAR-CLIP	22291592
MIRT497819	hsa-miR-423-5p	PAR-CLIP	22291592
MIRT497818	hsa-miR-1914-3p	PAR-CLIP	22291592
MIRT497817	hsa-miR-5194	PAR-CLIP	22291592
MIRT497816	hsa-miR-6738-5p	PAR-CLIP	22291592
MIRT497815	hsa-miR-526b-5p	PAR-CLIP	22291592
MIRT497814	hsa-miR-6834-5p	PAR-CLIP	22291592
MIRT497813	hsa-miR-1226-5p	PAR-CLIP	22291592
MIRT497812	hsa-miR-6734-5p	PAR-CLIP	22291592
MIRT497811	hsa-miR-335-3p	PAR-CLIP	22291592
MIRT1396002	hsa-miR-1229	CLIP-seq
MIRT1396003	hsa-miR-1237	CLIP-seq
MIRT1396004	hsa-miR-1248	CLIP-seq
MIRT1396005	hsa-miR-1251	CLIP-seq
MIRT1396006	hsa-miR-1273e	CLIP-seq
MIRT1396007	hsa-miR-1275	CLIP-seq
MIRT1396008	hsa-miR-129-5p	CLIP-seq
MIRT1396009	hsa-miR-1324	CLIP-seq
MIRT1396010	hsa-miR-134	CLIP-seq
MIRT1396011	hsa-miR-138	CLIP-seq
MIRT1396012	hsa-miR-1827	CLIP-seq
MIRT1396013	hsa-miR-19a	CLIP-seq
MIRT1396014	hsa-miR-19b	CLIP-seq
MIRT1396015	hsa-miR-302f	CLIP-seq
MIRT1396016	hsa-miR-3074-3p	CLIP-seq
MIRT1396017	hsa-miR-3118	CLIP-seq
MIRT1396018	hsa-miR-3131	CLIP-seq
MIRT1396019	hsa-miR-3155	CLIP-seq
MIRT1396020	hsa-miR-3155b	CLIP-seq
MIRT1396021	hsa-miR-3164	CLIP-seq
MIRT1396022	hsa-miR-3166	CLIP-seq
MIRT1396023	hsa-miR-3175	CLIP-seq
MIRT1396024	hsa-miR-3591-3p	CLIP-seq
MIRT1396025	hsa-miR-3613-3p	CLIP-seq
MIRT1396026	hsa-miR-3620	CLIP-seq
MIRT1396027	hsa-miR-3622a-5p	CLIP-seq
MIRT1396028	hsa-miR-3654	CLIP-seq
MIRT1396029	hsa-miR-3665	CLIP-seq
MIRT1396030	hsa-miR-3673	CLIP-seq
MIRT1396031	hsa-miR-3685	CLIP-seq
MIRT1396032	hsa-miR-3942-3p	CLIP-seq
MIRT1396033	hsa-miR-4299	CLIP-seq
MIRT1396034	hsa-miR-4423-3p	CLIP-seq
MIRT1396035	hsa-miR-4447	CLIP-seq
MIRT1396036	hsa-miR-4472	CLIP-seq
MIRT1396037	hsa-miR-4525	CLIP-seq
MIRT1396038	hsa-miR-4638-3p	CLIP-seq
MIRT1396039	hsa-miR-4639-3p	CLIP-seq
MIRT1396040	hsa-miR-4651	CLIP-seq
MIRT1396041	hsa-miR-4665-5p	CLIP-seq
MIRT1396042	hsa-miR-4705	CLIP-seq
MIRT1396043	hsa-miR-4723-5p	CLIP-seq
MIRT1396044	hsa-miR-4731-3p	CLIP-seq
MIRT1396045	hsa-miR-4736	CLIP-seq
MIRT1396046	hsa-miR-4747-5p	CLIP-seq
MIRT1396047	hsa-miR-4753-3p	CLIP-seq
MIRT1396048	hsa-miR-4797-5p	CLIP-seq
MIRT1396049	hsa-miR-4801	CLIP-seq
MIRT1396050	hsa-miR-484	CLIP-seq
MIRT1396051	hsa-miR-501-3p	CLIP-seq
MIRT1396052	hsa-miR-502-3p	CLIP-seq
MIRT1396053	hsa-miR-608	CLIP-seq
MIRT1396054	hsa-miR-611	CLIP-seq
MIRT1396055	hsa-miR-618	CLIP-seq
MIRT1396056	hsa-miR-625	CLIP-seq
MIRT1396057	hsa-miR-645	CLIP-seq
MIRT1396058	hsa-miR-758	CLIP-seq
MIRT1396059	hsa-miR-759	CLIP-seq
MIRT1396060	hsa-miR-764	CLIP-seq
MIRT1396061	hsa-miR-940	CLIP-seq
MIRT1396062	hsa-miR-943	CLIP-seq
MIRT2118735	hsa-miR-1262	CLIP-seq
MIRT2118736	hsa-miR-1285	CLIP-seq
MIRT2118737	hsa-miR-1343	CLIP-seq
MIRT1396011	hsa-miR-138	CLIP-seq
MIRT1396012	hsa-miR-1827	CLIP-seq
MIRT2118738	hsa-miR-185	CLIP-seq
MIRT2118739	hsa-miR-1976	CLIP-seq
MIRT1396013	hsa-miR-19a	CLIP-seq
MIRT1396014	hsa-miR-19b	CLIP-seq
MIRT2118740	hsa-miR-3123	CLIP-seq
MIRT1396023	hsa-miR-3175	CLIP-seq
MIRT2118741	hsa-miR-3183	CLIP-seq
MIRT2118742	hsa-miR-3185	CLIP-seq
MIRT2118743	hsa-miR-3187-5p	CLIP-seq
MIRT2118744	hsa-miR-3192	CLIP-seq
MIRT2118745	hsa-miR-342-5p	CLIP-seq
MIRT1396025	hsa-miR-3613-3p	CLIP-seq
MIRT1396029	hsa-miR-3665	CLIP-seq
MIRT2118746	hsa-miR-3929	CLIP-seq
MIRT2118747	hsa-miR-4270	CLIP-seq
MIRT1396033	hsa-miR-4299	CLIP-seq
MIRT2118748	hsa-miR-4306	CLIP-seq
MIRT2118749	hsa-miR-4311	CLIP-seq
MIRT2118750	hsa-miR-4419b	CLIP-seq
MIRT2118751	hsa-miR-4441	CLIP-seq
MIRT2118752	hsa-miR-4459	CLIP-seq
MIRT2118753	hsa-miR-4478	CLIP-seq
MIRT2118754	hsa-miR-4481	CLIP-seq
MIRT2118755	hsa-miR-4641	CLIP-seq
MIRT2118756	hsa-miR-4644	CLIP-seq
MIRT2118757	hsa-miR-4664-5p	CLIP-seq
MIRT2118758	hsa-miR-4699-5p	CLIP-seq
MIRT2118759	hsa-miR-4701-3p	CLIP-seq
MIRT2118760	hsa-miR-4722-5p	CLIP-seq
MIRT2118761	hsa-miR-4723-3p	CLIP-seq
MIRT1396045	hsa-miR-4736	CLIP-seq
MIRT2118762	hsa-miR-4745-5p	CLIP-seq
MIRT2118763	hsa-miR-4749-3p	CLIP-seq
MIRT2118764	hsa-miR-4767	CLIP-seq
MIRT2118765	hsa-miR-4779	CLIP-seq
MIRT2118766	hsa-miR-485-5p	CLIP-seq
MIRT2118767	hsa-miR-612	CLIP-seq
MIRT2118768	hsa-miR-615-5p	CLIP-seq
MIRT2118769	hsa-miR-637	CLIP-seq
MIRT1396060	hsa-miR-764	CLIP-seq
MIRT1396061	hsa-miR-940	CLIP-seq
MIRT1396008	hsa-miR-129-5p	CLIP-seq
MIRT1396010	hsa-miR-134	CLIP-seq
MIRT2340979	hsa-miR-141	CLIP-seq
MIRT1396013	hsa-miR-19a	CLIP-seq
MIRT1396014	hsa-miR-19b	CLIP-seq
MIRT2340980	hsa-miR-200a	CLIP-seq
MIRT2340981	hsa-miR-23a	CLIP-seq
MIRT2340982	hsa-miR-23b	CLIP-seq
MIRT2340983	hsa-miR-23c	CLIP-seq
MIRT2340984	hsa-miR-27a	CLIP-seq
MIRT2340985	hsa-miR-27b	CLIP-seq
MIRT2340986	hsa-miR-3117-5p	CLIP-seq
MIRT1396017	hsa-miR-3118	CLIP-seq
MIRT2340987	hsa-miR-3129-3p	CLIP-seq
MIRT1396021	hsa-miR-3164	CLIP-seq
MIRT2340988	hsa-miR-3176	CLIP-seq
MIRT2340989	hsa-miR-320e	CLIP-seq
MIRT2340990	hsa-miR-3922-3p	CLIP-seq
MIRT2340991	hsa-miR-3923	CLIP-seq
MIRT2340992	hsa-miR-3974	CLIP-seq
MIRT1396033	hsa-miR-4299	CLIP-seq
MIRT2340993	hsa-miR-4312	CLIP-seq
MIRT2340994	hsa-miR-4470	CLIP-seq
MIRT2340995	hsa-miR-4699-3p	CLIP-seq
MIRT2118758	hsa-miR-4699-5p	CLIP-seq
MIRT2340996	hsa-miR-4722-3p	CLIP-seq
MIRT2340997	hsa-miR-4755-3p	CLIP-seq
MIRT2340998	hsa-miR-496	CLIP-seq
MIRT2340999	hsa-miR-513a-5p	CLIP-seq
MIRT2341000	hsa-miR-514	CLIP-seq
MIRT2341001	hsa-miR-514b-3p	CLIP-seq
MIRT1396058	hsa-miR-758	CLIP-seq
MIRT2395297	hsa-miR-1271	CLIP-seq
MIRT1396013	hsa-miR-19a	CLIP-seq
MIRT1396014	hsa-miR-19b	CLIP-seq
MIRT2395298	hsa-miR-4264	CLIP-seq
MIRT2395299	hsa-miR-4797-3p	CLIP-seq
MIRT2395300	hsa-miR-935	CLIP-seq
MIRT2395301	hsa-miR-96	CLIP-seq
MIRT1396003	hsa-miR-1237	CLIP-seq
MIRT1396004	hsa-miR-1248	CLIP-seq
MIRT2634870	hsa-miR-1287	CLIP-seq
MIRT1396011	hsa-miR-138	CLIP-seq
MIRT1396012	hsa-miR-1827	CLIP-seq
MIRT2634871	hsa-miR-204	CLIP-seq
MIRT2634872	hsa-miR-211	CLIP-seq
MIRT2634873	hsa-miR-218	CLIP-seq
MIRT2634874	hsa-miR-2355-3p	CLIP-seq
MIRT2634875	hsa-miR-296-3p	CLIP-seq
MIRT2634876	hsa-miR-3135b	CLIP-seq
MIRT2634877	hsa-miR-3160-5p	CLIP-seq
MIRT1396029	hsa-miR-3665	CLIP-seq
MIRT2634878	hsa-miR-3680	CLIP-seq
MIRT2634879	hsa-miR-4257	CLIP-seq
MIRT2634880	hsa-miR-4272	CLIP-seq
MIRT2634881	hsa-miR-4279	CLIP-seq
MIRT2634882	hsa-miR-4287	CLIP-seq
MIRT1396033	hsa-miR-4299	CLIP-seq
MIRT2634883	hsa-miR-4330	CLIP-seq
MIRT2634884	hsa-miR-4432	CLIP-seq
MIRT2634885	hsa-miR-4646-3p	CLIP-seq
MIRT2634886	hsa-miR-4685-3p	CLIP-seq
MIRT2634887	hsa-miR-4691-3p	CLIP-seq
MIRT1396045	hsa-miR-4736	CLIP-seq
MIRT1396047	hsa-miR-4753-3p	CLIP-seq
MIRT2634888	hsa-miR-636	CLIP-seq
MIRT2634889	hsa-miR-676	CLIP-seq
MIRT1396060	hsa-miR-764	CLIP-seq
MIRT1396061	hsa-miR-940	CLIP-seq
MIRT2634890	hsa-miR-942	CLIP-seq
MIRT2634870	hsa-miR-1287	CLIP-seq
MIRT1396011	hsa-miR-138	CLIP-seq
MIRT1396012	hsa-miR-1827	CLIP-seq
MIRT2634873	hsa-miR-218	CLIP-seq
MIRT2634875	hsa-miR-296-3p	CLIP-seq
MIRT2634876	hsa-miR-3135b	CLIP-seq
MIRT2634877	hsa-miR-3160-5p	CLIP-seq
MIRT1396029	hsa-miR-3665	CLIP-seq
MIRT2634878	hsa-miR-3680	CLIP-seq
MIRT2634879	hsa-miR-4257	CLIP-seq
MIRT2634881	hsa-miR-4279	CLIP-seq
MIRT1396033	hsa-miR-4299	CLIP-seq
MIRT2634883	hsa-miR-4330	CLIP-seq
MIRT2634884	hsa-miR-4432	CLIP-seq
MIRT1396045	hsa-miR-4736	CLIP-seq
MIRT2634888	hsa-miR-636	CLIP-seq
MIRT1396060	hsa-miR-764	CLIP-seq
MIRT1396061	hsa-miR-940	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
ZNF382	Repression	20682794

Show/Hide all(64)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001553	Process	Luteinization	IEA
GO:0001779	Process	Natural killer cell differentiation	IEA
GO:0003682	Function	Chromatin binding	ISS
GO:0003700	Function	DNA-binding transcription factor activity	TAS	8631883
GO:0005515	Function	Protein binding	IPI	9989503, 21106534, 31175292, 32296183
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006952	Process	Defense response	IBA	21873635
GO:0007259	Process	Receptor signaling pathway via JAK-STAT	IBA	21873635
GO:0007565	Process	Female pregnancy	IEA
GO:0007595	Process	Lactation	IEA
GO:0019218	Process	Regulation of steroid metabolic process	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019530	Process	Taurine metabolic process	ISS
GO:0019915	Process	Lipid storage	IEA
GO:0030856	Process	Regulation of epithelial cell differentiation	IEA
GO:0032355	Process	Response to estradiol	IDA	12552091
GO:0032743	Process	Positive regulation of interleukin-2 production	IEA
GO:0032819	Process	Positive regulation of natural killer cell proliferation	IEA
GO:0032825	Process	Positive regulation of natural killer cell differentiation	IEA
GO:0032870	Process	Cellular response to hormone stimulus	IDA	12552091
GO:0033077	Process	T cell differentiation in thymus	IEA
GO:0035259	Function	Glucocorticoid receptor binding	IPI	12552091
GO:0035723	Process	Interleukin-15-mediated signaling pathway	TAS
GO:0038110	Process	Interleukin-2-mediated signaling pathway	TAS
GO:0038111	Process	Interleukin-7-mediated signaling pathway	TAS
GO:0038113	Process	Interleukin-9-mediated signaling pathway	TAS
GO:0040014	Process	Regulation of multicellular organism growth	ISS
GO:0040018	Process	Positive regulation of multicellular organism growth	IEA
GO:0042104	Process	Positive regulation of activated T cell proliferation	IEA
GO:0042127	Process	Regulation of cell population proliferation	IBA	21873635
GO:0042448	Process	Progesterone metabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	31175292
GO:0043029	Process	T cell homeostasis	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043434	Process	Response to peptide hormone	IBA	21873635
GO:0045579	Process	Positive regulation of B cell differentiation	IEA
GO:0045588	Process	Positive regulation of gamma-delta T cell differentiation	IEA
GO:0045647	Process	Negative regulation of erythrocyte differentiation	IEA
GO:0045648	Process	Positive regulation of erythrocyte differentiation	IDA	20702587
GO:0045931	Process	Positive regulation of mitotic cell cycle	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0045954	Process	Positive regulation of natural killer cell mediated cytotoxicity	IEA
GO:0046543	Process	Development of secondary female sexual characteristics	IEA
GO:0046544	Process	Development of secondary male sexual characteristics	IEA
GO:0046983	Function	Protein dimerization activity	ISS
GO:0048541	Process	Peyer's patch development	IEA
GO:0050729	Process	Positive regulation of inflammatory response	IEA
GO:0060397	Process	Growth hormone receptor signaling pathway via JAK-STAT	IBA	21873635
GO:0060397	Process	Growth hormone receptor signaling pathway via JAK-STAT	IDA	12552091
GO:0060397	Process	Growth hormone receptor signaling pathway via JAK-STAT	TAS
GO:0070670	Process	Response to interleukin-4	IEA
GO:0071363	Process	Cellular response to growth factor stimulus	ISS
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	ISS
GO:0097531	Process	Mast cell migration	IEA

MIM	HGNC	e!Ensembl
604260	11367	ENSG00000173757

Protein

UniProt ID

P51692

Protein name

Signal transducer and activator of transcription 5B

Protein function

Carries out a dual function: signal transduction and activation of transcription (PubMed:29844444). Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.

PDB

6MBW , 6MBZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02865	STAT_int	2 → 124	STAT protein, protein interaction domain	Domain
PF01017	STAT_alpha	141 → 324	STAT protein, all-alpha domain	Family
PF02864	STAT_bind	336 → 469	STAT protein, DNA binding domain	Domain
PF00017	SH2	589 → 670	SH2 domain	Domain

Sequence

MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
LKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
WIPHAQS

Sequence length

787

Interactions

View interactions

	KEGG		Reactome
	ErbB signaling pathway Chemokine signaling pathway Hormone signaling Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Prolactin signaling pathway AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Hepatitis B Measles Human T-cell leukemia virus 1 infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer		Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Growth hormone receptor signaling

Associated diseases

Show/Hide Causal Diseases (12)

Causal
Disease name	Disease term	dbSNP ID	References
Anemia	Anemia	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	31036433
Carcinoma	Basal cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259
Growth hormone insensitivity with immune dysregulation	Laron syndrome with immunodeficiency	rs121908501, rs121908502, rs1555548680, rs1555548678, rs1555549674, rs761761205
Hypofibrinogenemia	Hypofibrinogenemia	rs121913087, rs121913088, rs587776837, rs121909616, rs121909625, rs121909608, rs121909607, rs146387238, rs1578795296, rs1214070111, rs776817952, rs762964798, rs121909606, rs1414035000, rs1310452604
Isolated somatotropin deficiency	Isolated somatotropin deficiency	rs797044450, rs71640277, rs863223306, rs2144738731, rs863223307, rs2144739370, rs863223309, rs863223310, rs137853223, rs2144739380, rs2144739391
Laron syndrome	Laron syndrome type 2	rs730880282, rs121909364, rs1579675001, rs121909365	26703237, 15827093, 13679528, 22419735, 17030597, 16787985
Lymphoblastic leukemia	Leukemia, Large Granular Lymphocytic, Leukemia, Natural Killer Cell Large Granular Lymphocytic, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591	29200404, 26192916, 26192916, 29200404, 29200404
Lymphoma	Lymphoma, T-Cell, Cutaneous, Lymphoma, Extranodal NK-T-Cell	rs11540652, rs1592119138, rs1592123162, rs1599367044	26192916, 29200404
Neutropenia	Neutropenia	rs879253882
Pancytopenia	Pancytopenia	rs869312883, rs770551610, rs1131690788, rs530073586, rs374333820
Severe combined immunodeficiency disease	Combined immunodeficiency	rs886037607, rs118203993, rs121908714, rs121908739, rs121908740, rs121908735, rs121908721, rs121908722, rs121908156, rs1564414523, rs1564418254, rs1564446526, rs786205074, rs121908157, rs121908159, rs786200884, rs397515357, rs104894562, rs137852624, rs137852625, rs137852626, rs137852627, rs137852507, rs137852509, rs111033619, rs111033620, rs1569480018, rs111033621, rs137852510, rs587776729, rs111033622, rs111033617, rs111033618, rs121917894, rs121917896, rs2133313409, rs121917897, rs28933392, rs104894282, rs104894283, rs104894285, rs121918570, rs121918572, rs730880318, rs104893674, rs730880319, rs104894453, rs104894454, rs104894451, rs137853206, rs777503956, rs267606645, rs267606648, rs397515390, rs193922346, rs193922347, rs193922348, rs193922349, rs193922350, rs137852508, rs193922640, rs193922641, rs193922643, rs193922645, rs193922361, rs193922364, rs193922464, rs148508754, rs193922574, rs113994174, rs606231246, rs397514671, rs397514686, rs397514755, rs199474679, rs199474685, rs199474686, rs199474681, rs150739647, rs267605358, rs886041036, rs587777335, rs587778405, rs145092287, rs587777562, rs606231256, rs200296680, rs786205456, rs786205517, rs774202259, rs786205615, rs878853261, rs786205890, rs782753385, rs746052951, rs869025224, rs869312857, rs869320660, rs869320659, rs869320658, rs879253742, rs886037924, rs886037925, rs750610248, rs886039394, rs761242509, rs886039387, rs886041043, rs886041044, rs886042051, rs886041333, rs749481781, rs1057517747, rs1057519506, rs1057523762, rs1057521062, rs1057520644, rs761583890, rs751635016, rs55729925, rs1064793248, rs1064793347, rs1064794027, rs781410769, rs1555524788, rs1486760100, rs769633203, rs1556330713, rs1555322558, rs1556330234, rs1556330755, rs1556329779, rs1556330552, rs1556329822, rs1556330286, rs1556331272, rs2146178281, rs376610445, rs757797994, rs775704953, rs1555743321, rs1564995660, rs1564995662, rs1556330249, rs144104577, rs886041796, rs1026474882, rs570768621, rs1556330562, rs1556330568, rs780014431, rs778343059, rs1555844617, rs1567629968, rs1567628757, rs1567629943, rs1567632864, rs1567632829, rs1567626023, rs1559328006, rs1561423197, rs1452483770, rs1568400897, rs1569479913, rs1568404443, rs1569480047, rs1563340753, rs368303189, rs1568431262, rs1568431102, rs1561424886, rs1602289943, rs1241698978, rs1569479994, rs1569480082, rs1602289649, rs1573261820, rs770985198, rs1589050343, rs1340132582, rs1589064324, rs1589070600, rs1213680890, rs149316157, rs1599873591, rs755706305, rs1602288051, rs1602289411, rs1602289183, rs1583513256, rs1589136659, rs1380154594, rs1011307501, rs1599876167, rs1569967422, rs1602289631, rs1573262398, rs760191638, rs1592117677, rs1640406042, rs372597855, rs1839558393, rs1839622622, rs1839957089, rs777008519, rs1233957241, rs2092261618, rs1839255008, rs1677695565, rs936493226, rs1162344514, rs991089005	26703237

Show/Hide Unknown Diseases (17)

Unknown
Disease name	Disease term	dbSNP ID	References
Anorexia	Anorexia
Diffuse alveolar hemorrhage	Diffuse alveolar hemorrhage
Disseminated intravascular coagulation	Disseminated Intravascular Coagulation
Dwarfism	Dwarfism
Eczema	Eczema
Enteropathy-associated t-cell lymphoma	Enteropathy-Associated T-Cell Lymphoma		29200404
Extranodal nk t cell lymphoma	Nasal Type Extranodal NK/T-Cell Lymphoma		29200404
Fibrinogen deficiency	Fibrinogen Deficiency
Gangrene	Gangrene
Granulomatous slack skin	Granulomatous Slack Skin		26192916
Leukopenia	Leukopenia
Promyelocytic leukemia	Acute Promyelocytic Leukemia		18221386
Somatotropin deficiency	Somatotropin deficiency
Stomatitis	Stomatitis
T-cell lymphocytic leukemia	T-Cell Large Granular Lymphocyte Leukemia, Leukemia, T-Cell, Chronic		29200404, 26192916, 29200404
T-cell lymphoma	T-Cell Lymphoma		26192917
T-cell prolymphocytic leukemia	T-Cell Prolymphocytic Leukemia		29200404

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