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STAT4 (signal transducer and activator of transcription 4)
Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6775
Gene nameGene Name - the full gene name approved by the HGNC.
Signal transducer and activator of transcription 4
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
STAT4
SynonymsGene synonyms aliases
DPMC, SLEB11
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q32.2-q32.3
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that tran
SNPsSNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
SNP ID Visualize variation Clinical significance Consequence
rs7574865 T>A,G Risk-factor Intron variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT052905 hsa-miR-141-3p Luciferase reporter assay, qRT-PCR, Western blot 24732377
MIRT052905 hsa-miR-141-3p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 24732377
MIRT052905 hsa-miR-141-3p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 24732377
MIRT736510 hsa-miR-200a-3p Luciferase reporter assay, Western blotting, qRT-PCR 33552256
MIRT052905 hsa-miR-141-3p Luciferase reporter assay, Western blotting, qRT-PCR 33552256
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
GATA3 Repression 21632975
NFKB1 Unknown 17046972
RELA Unknown 17046972
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0003700 Function DNA-binding transcription factor activity TAS 9284918
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q14765
Protein name Signal transducer and activator of transcription 4
Protein function Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response (PubMed:10961885, PubMed:37256972, PubMed:8943379). Plays a key role in the differentiation of T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02865 STAT_int
2 → 120
STAT protein, protein interaction domain
 Domain
PF01017 STAT_alpha
140 → 308
STAT protein, all-alpha domain
 Family
PF02864 STAT_bind
320 → 454
STAT protein, DNA binding domain
 Domain
PF00017 SH2
569 → 645
SH2 domain
 Domain
Sequence
Sequence length 748
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Necroptosis
JAK-STAT signaling pathway
Th1 and Th2 cell differentiation
Hepatitis B
Pathways in cancer
Inflammatory bowel disease 		  Interleukin-20 family signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-21 signaling
Associated diseases
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Apraxia Apraxias rs121908377, rs121908378, rs1135401820, rs1178491246, rs1584969672
Arthritis Arthritis, Systemic onset juvenile chronic arthritis, Juvenile arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 23603761
Autoimmune diseases Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 rs41285370, rs869025224 21383967, 30595370, 30595370
Behcet syndrome Behcet Syndrome, Behçet disease rs886040969, rs886039866, rs746055479, rs752615209, rs774164456, rs751454741 26097239, 23001997, 23291587
Unknown
Disease name Disease term dbSNP ID References
Acne Acne
Alopecia Alopecia
Anorexia Anorexia
Aortic valve insufficiency Aortic Valve Insufficiency

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