ZFP36L1 (ZFP36 ring finger protein like 1)
|
Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
677 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
ZFP36 ring finger protein like 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
ZFP36L1 |
SynonymsGene synonyms aliases
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BRF1, Berg36, ERF-1, ERF1, RNF162B, TIS11B, cMG1 |
ChromosomeChromosome number
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14 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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14q24.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000165 |
Process |
MAPK cascade |
IDA |
18326031, 20166898 |
GO:0000288 |
Process |
Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
IEA |
|
GO:0000932 |
Component |
P-body |
IDA |
17369404 |
GO:0001570 |
Process |
Vasculogenesis |
IEA |
|
GO:0003342 |
Process |
Proepicardium development |
IEA |
|
GO:0003677 |
Function |
DNA binding |
IEA |
|
GO:0003723 |
Function |
RNA binding |
HDA |
22658674 |
GO:0003729 |
Function |
MRNA binding |
IDA |
15467755 |
GO:0005515 |
Function |
Protein binding |
IPI |
15687258, 16189514, 18326031, 25106868 |
GO:0005634 |
Component |
Nucleus |
IDA |
12198173, 21832157 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
12198173 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006397 |
Process |
MRNA processing |
IEA |
|
GO:0006915 |
Process |
Apoptotic process |
IEA |
|
GO:0007507 |
Process |
Heart development |
IEA |
|
GO:0008283 |
Process |
Cell population proliferation |
IEA |
|
GO:0009611 |
Process |
Response to wounding |
IDA |
27182009 |
GO:0010468 |
Process |
Regulation of gene expression |
IDA |
20166898 |
GO:0010837 |
Process |
Regulation of keratinocyte proliferation |
IMP |
27182009 |
GO:0014065 |
Process |
Phosphatidylinositol 3-kinase signaling |
IDA |
15538381 |
GO:0021915 |
Process |
Neural tube development |
IEA |
|
GO:0031086 |
Process |
Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay |
ISS |
|
GO:0031440 |
Process |
Regulation of mRNA 3'-end processing |
IDA |
21832157 |
GO:0032869 |
Process |
Cellular response to insulin stimulus |
IDA |
15538381 |
GO:0033077 |
Process |
T cell differentiation in thymus |
ISS |
|
GO:0035264 |
Process |
Multicellular organism growth |
IEA |
|
GO:0035925 |
Function |
MRNA 3'-UTR AU-rich region binding |
IDA |
12198173, 15467755, 15538381, 18326031, 19179481, 20702587, 21832157, 24700863, 25014217, 25106868, 26542173 |
GO:0038066 |
Process |
P38MAPK cascade |
ISS |
|
GO:0043488 |
Process |
Regulation of mRNA stability |
IDA |
15467755, 15538381, 15687258, 18326031, 19179481, 20702587, 24700863, 25014217, 26542173 |
GO:0043488 |
Process |
Regulation of mRNA stability |
IMP |
12198173, 25106868 |
GO:0043488 |
Process |
Regulation of mRNA stability |
TAS |
|
GO:0043491 |
Process |
Protein kinase B signaling |
ISS |
|
GO:0044344 |
Process |
Cellular response to fibroblast growth factor stimulus |
ISS |
|
GO:0045577 |
Process |
Regulation of B cell differentiation |
ISS |
|
GO:0045600 |
Process |
Positive regulation of fat cell differentiation |
ISS |
|
GO:0045616 |
Process |
Regulation of keratinocyte differentiation |
IMP |
27182009 |
GO:0045647 |
Process |
Negative regulation of erythrocyte differentiation |
IDA |
20702587 |
GO:0045657 |
Process |
Positive regulation of monocyte differentiation |
IDA |
26542173 |
GO:0045661 |
Process |
Regulation of myoblast differentiation |
ISS |
|
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:0048382 |
Process |
Mesendoderm development |
ISS |
|
GO:0051028 |
Process |
MRNA transport |
IMP |
17369404 |
GO:0060710 |
Process |
Chorio-allantoic fusion |
IEA |
|
GO:0061158 |
Process |
3'-UTR-mediated mRNA destabilization |
IDA |
15467755, 15538381, 15687258, 18326031, 19179481, 24700863, 26542173 |
GO:0061158 |
Process |
3'-UTR-mediated mRNA destabilization |
IMP |
12198173, 25014217, 25106868 |
GO:0070371 |
Process |
ERK1 and ERK2 cascade |
IDA |
25106868 |
GO:0071320 |
Process |
Cellular response to cAMP |
IDA |
19179481 |
GO:0071356 |
Process |
Cellular response to tumor necrosis factor |
IDA |
20166898 |
GO:0071364 |
Process |
Cellular response to epidermal growth factor stimulus |
IDA |
20166898 |
GO:0071375 |
Process |
Cellular response to peptide hormone stimulus |
IDA |
15467755, 19179481 |
GO:0071385 |
Process |
Cellular response to glucocorticoid stimulus |
IDA |
20166898 |
GO:0071456 |
Process |
Cellular response to hypoxia |
IMP |
21832157 |
GO:0071472 |
Process |
Cellular response to salt stress |
ISS |
|
GO:0071560 |
Process |
Cellular response to transforming growth factor beta stimulus |
IDA |
20166898 |
GO:0071889 |
Function |
14-3-3 protein binding |
IDA |
15538381, 18326031 |
GO:0072091 |
Process |
Regulation of stem cell proliferation |
ISS |
|
GO:0097403 |
Process |
Cellular response to raffinose |
ISS |
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GO:1900153 |
Process |
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
ISS |
|
GO:1901991 |
Process |
Negative regulation of mitotic cell cycle phase transition |
ISS |
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GO:1902172 |
Process |
Regulation of keratinocyte apoptotic process |
IMP |
27182009 |
GO:1904582 |
Process |
Positive regulation of intracellular mRNA localization |
IMP |
17369404 |
GO:1990904 |
Component |
Ribonucleoprotein complex |
IDA |
15687258, 20702587, 21832157, 26542173 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q07352 |
Protein name |
mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1) |
Protein function |
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (Pu |
PDB |
1W0V
,
1W0W
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF04553 |
Tis11B_N |
1 → 106 |
Tis11B like protein, N terminus |
Family |
PF00642 |
zf-CCCH |
115 → 141 |
Zinc finger C-x8-C-x5-C-x3-H type (and similar) |
Family |
PF00642 |
zf-CCCH |
153 → 178 |
Zinc finger C-x8-C-x5-C-x3-H type (and similar) |
Family |
|
Sequence |
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Sequence length |
338 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Arthritis |
Systemic onset juvenile chronic arthritis |
rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 |
23603761 |
Diabetes mellitus |
Diabetes Mellitus, Insulin-Dependent |
rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261 |
21980299 |
Multiple sclerosis |
Multiple Sclerosis |
rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544 |
24076602 |
Rheumatoid arthritis |
Rheumatoid Arthritis, Systemic Juvenile |
rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 |
23603761 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Celiac disease |
Celiac Disease |
rs2305764, rs35218876 |
22057235 |
Oligoarticular arthritis |
Oligoarticular Juvenile Idiopathic Arthritis |
|
23603761 |
Pauciarticular chronic arthritis |
Juvenile pauciarticular chronic arthritis |
|
23603761 |
Seronegative polyarthritis |
Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative |
|
23603761 |
Respiratory tract diseases |
Respiratory Tract Diseases |
|
30595370 |
Still disease |
Juvenile-Onset Still Disease |
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23603761 |
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