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SSTR3 (somatostatin receptor 3)

Gene

6753

Somatostatin receptor 3

SSTR3

SS-3-R, SS3-R, SS3R, SSR-28, SST3

22q13.1

This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of

Show/Hide all(169)

miRTarBase ID	miRNA	Experiments	Reference
MIRT714170	hsa-miR-3918	HITS-CLIP	19536157
MIRT714169	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT714168	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT495173	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT495171	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT714167	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT714166	hsa-miR-6749-5p	HITS-CLIP	19536157
MIRT714165	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT714164	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT714163	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT714162	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT647420	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT647418	hsa-miR-4761-3p	HITS-CLIP	23824327
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT647416	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT647415	hsa-miR-4780	HITS-CLIP	23824327
MIRT647414	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT647413	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647412	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647411	hsa-miR-4287	HITS-CLIP	23824327
MIRT647410	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647408	hsa-miR-4493	HITS-CLIP	23824327
MIRT647409	hsa-miR-711	HITS-CLIP	23824327
MIRT647407	hsa-miR-623	HITS-CLIP	23824327
MIRT647406	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT647405	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT647403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT647404	hsa-miR-4776-5p	HITS-CLIP	23824327
MIRT647402	hsa-miR-4535	HITS-CLIP	23824327
MIRT647420	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT647418	hsa-miR-4761-3p	HITS-CLIP	23824327
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT647416	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT647415	hsa-miR-4780	HITS-CLIP	23824327
MIRT647414	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT647413	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647412	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647411	hsa-miR-4287	HITS-CLIP	23824327
MIRT647410	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647408	hsa-miR-4493	HITS-CLIP	23824327
MIRT647409	hsa-miR-711	HITS-CLIP	23824327
MIRT647407	hsa-miR-623	HITS-CLIP	23824327
MIRT647406	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT647405	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT647403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT647404	hsa-miR-4776-5p	HITS-CLIP	23824327
MIRT647402	hsa-miR-4535	HITS-CLIP	23824327
MIRT495177	hsa-miR-6854-5p	PAR-CLIP	22291592
MIRT495176	hsa-miR-4690-3p	PAR-CLIP	22291592
MIRT495175	hsa-miR-5685	PAR-CLIP	22291592
MIRT495174	hsa-miR-6798-5p	PAR-CLIP	22291592
MIRT495173	hsa-miR-1915-3p	PAR-CLIP	22291592
MIRT495171	hsa-miR-6764-5p	PAR-CLIP	22291592
MIRT495172	hsa-miR-3926	PAR-CLIP	22291592
MIRT495170	hsa-miR-6762-5p	PAR-CLIP	22291592
MIRT495169	hsa-miR-6845-5p	PAR-CLIP	22291592
MIRT495168	hsa-miR-328-5p	PAR-CLIP	22291592
MIRT495167	hsa-miR-6885-5p	PAR-CLIP	22291592
MIRT495177	hsa-miR-6854-5p	PAR-CLIP	23708386
MIRT495176	hsa-miR-4690-3p	PAR-CLIP	23708386
MIRT495175	hsa-miR-5685	PAR-CLIP	23708386
MIRT495174	hsa-miR-6798-5p	PAR-CLIP	23708386
MIRT495173	hsa-miR-1915-3p	PAR-CLIP	23708386
MIRT495171	hsa-miR-6764-5p	PAR-CLIP	23708386
MIRT495172	hsa-miR-3926	PAR-CLIP	23708386
MIRT495170	hsa-miR-6762-5p	PAR-CLIP	23708386
MIRT495169	hsa-miR-6845-5p	PAR-CLIP	23708386
MIRT495168	hsa-miR-328-5p	PAR-CLIP	23708386
MIRT495167	hsa-miR-6885-5p	PAR-CLIP	23708386
MIRT714170	hsa-miR-3918	HITS-CLIP	19536157
MIRT714169	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT714168	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT495173	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT495171	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT714167	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT714166	hsa-miR-6749-5p	HITS-CLIP	19536157
MIRT714165	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT714164	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT714163	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT714162	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT647420	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT647418	hsa-miR-4761-3p	HITS-CLIP	23824327
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT647416	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT647415	hsa-miR-4780	HITS-CLIP	23824327
MIRT647414	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT647413	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647412	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647411	hsa-miR-4287	HITS-CLIP	23824327
MIRT647410	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647408	hsa-miR-4493	HITS-CLIP	23824327
MIRT647409	hsa-miR-711	HITS-CLIP	23824327
MIRT647407	hsa-miR-623	HITS-CLIP	23824327
MIRT647406	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT647405	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT647403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT647404	hsa-miR-4776-5p	HITS-CLIP	23824327
MIRT647402	hsa-miR-4535	HITS-CLIP	23824327
MIRT647420	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT647418	hsa-miR-4761-3p	HITS-CLIP	23824327
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT647416	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT647415	hsa-miR-4780	HITS-CLIP	23824327
MIRT647414	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT647413	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647412	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647411	hsa-miR-4287	HITS-CLIP	23824327
MIRT647410	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647408	hsa-miR-4493	HITS-CLIP	23824327
MIRT647409	hsa-miR-711	HITS-CLIP	23824327
MIRT647407	hsa-miR-623	HITS-CLIP	23824327
MIRT647406	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT647405	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT647403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT647404	hsa-miR-4776-5p	HITS-CLIP	23824327
MIRT647402	hsa-miR-4535	HITS-CLIP	23824327
MIRT495177	hsa-miR-6854-5p	PAR-CLIP	22291592
MIRT495176	hsa-miR-4690-3p	PAR-CLIP	22291592
MIRT495175	hsa-miR-5685	PAR-CLIP	22291592
MIRT495174	hsa-miR-6798-5p	PAR-CLIP	22291592
MIRT495173	hsa-miR-1915-3p	PAR-CLIP	22291592
MIRT495171	hsa-miR-6764-5p	PAR-CLIP	22291592
MIRT495172	hsa-miR-3926	PAR-CLIP	22291592
MIRT495170	hsa-miR-6762-5p	PAR-CLIP	22291592
MIRT495169	hsa-miR-6845-5p	PAR-CLIP	22291592
MIRT495168	hsa-miR-328-5p	PAR-CLIP	22291592
MIRT495167	hsa-miR-6885-5p	PAR-CLIP	22291592
MIRT495177	hsa-miR-6854-5p	PAR-CLIP	23708386
MIRT495176	hsa-miR-4690-3p	PAR-CLIP	23708386
MIRT495175	hsa-miR-5685	PAR-CLIP	23708386
MIRT495174	hsa-miR-6798-5p	PAR-CLIP	23708386
MIRT495173	hsa-miR-1915-3p	PAR-CLIP	23708386
MIRT495171	hsa-miR-6764-5p	PAR-CLIP	23708386
MIRT495172	hsa-miR-3926	PAR-CLIP	23708386
MIRT495170	hsa-miR-6762-5p	PAR-CLIP	23708386
MIRT495169	hsa-miR-6845-5p	PAR-CLIP	23708386
MIRT495168	hsa-miR-328-5p	PAR-CLIP	23708386
MIRT495167	hsa-miR-6885-5p	PAR-CLIP	23708386
MIRT1392869	hsa-miR-3152-5p	CLIP-seq
MIRT1392870	hsa-miR-3157-5p	CLIP-seq
MIRT1392871	hsa-miR-4691-3p	CLIP-seq
MIRT1392872	hsa-miR-4763-5p	CLIP-seq
MIRT1392873	hsa-miR-4774-3p	CLIP-seq
MIRT1392874	hsa-miR-767-3p	CLIP-seq
MIRT1392869	hsa-miR-3152-5p	CLIP-seq
MIRT1392870	hsa-miR-3157-5p	CLIP-seq
MIRT1392871	hsa-miR-4691-3p	CLIP-seq
MIRT1392872	hsa-miR-4763-5p	CLIP-seq
MIRT1392873	hsa-miR-4774-3p	CLIP-seq
MIRT1392874	hsa-miR-767-3p	CLIP-seq
MIRT2339883	hsa-miR-3120-3p	CLIP-seq
MIRT1392869	hsa-miR-3152-5p	CLIP-seq
MIRT1392870	hsa-miR-3157-5p	CLIP-seq
MIRT2339884	hsa-miR-377	CLIP-seq
MIRT2339885	hsa-miR-3974	CLIP-seq
MIRT2339886	hsa-miR-451b	CLIP-seq
MIRT1392871	hsa-miR-4691-3p	CLIP-seq
MIRT2339887	hsa-miR-4714-3p	CLIP-seq
MIRT1392872	hsa-miR-4763-5p	CLIP-seq
MIRT1392873	hsa-miR-4774-3p	CLIP-seq
MIRT1392874	hsa-miR-767-3p	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004994	Function	Somatostatin receptor activity	IEA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	19071123, 22651821, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005929	Component	Cilium	IDA	28154160
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	8405411
GO:0007218	Process	Neuropeptide signaling pathway	IBA	21873635
GO:0007267	Process	Cell-cell signaling	TAS	1337145
GO:0007283	Process	Spermatogenesis	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	8961277
GO:0008628	Process	Hormone-mediated apoptotic signaling pathway	TAS	8961277
GO:0021549	Process	Cerebellum development	IEA
GO:0030900	Process	Forebrain development	IEA
GO:0038170	Process	Somatostatin signaling pathway	IEA
GO:0042277	Function	Peptide binding	IBA	21873635
GO:0042594	Process	Response to starvation	IEA
GO:0042923	Function	Neuropeptide binding	IBA	21873635
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0060170	Component	Ciliary membrane	TAS
GO:0071385	Process	Cellular response to glucocorticoid stimulus	IEA
GO:0071392	Process	Cellular response to estradiol stimulus	IEA
GO:0097730	Component	Non-motile cilium	ISS

MIM	HGNC	e!Ensembl
182453	11332	ENSG00000278195

Protein

UniProt ID

P32745

Protein name

Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SST3) (SSR-28)

Protein function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

PDB

8XIQ , 8XIR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	61 → 313	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLL
GNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVM
AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVV
FSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRV
WAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVA
LPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEE
SREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL

Sequence length

418

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Hormone signaling Growth hormone synthesis, secretion and action		Peptide ligand-binding receptors G alpha (i) signalling events BBSome-mediated cargo-targeting to cilium

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Pancreatic cancer	Malignant neoplasm of pancreas	rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431, rs200612497	17625444

Show/Hide Unknown Diseases (7)

Unknown
Disease name	Disease term	dbSNP ID	References
Grand mal status epilepticus	Grand Mal Status Epilepticus		18951627
Mood disorder	Mood Disorders		22560501
Neuroendocrine tumors	Neuroendocrine Tumors		17625444
Nonconvulsive status epilepticus	Non-Convulsive Status Epilepticus		18951627
Pancreatic neoplasm	Pancreatic Neoplasm		17625444
Petit mal status	Petit mal status		18951627
Status epilepticus	Status Epilepticus, Complex Partial Status Epilepticus, Status Epilepticus, Subclinical		18951627

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