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SSR2 (signal sequence receptor subunit 2)

Gene

6746

Signal sequence receptor subunit 2

SSR2

HSD25, TLAP, TRAP-BETA, TRAPB

1q22

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprote

Show/Hide all(179)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045638	hsa-miR-149-5p	CLASH	23622248
MIRT045273	hsa-miR-186-5p	CLASH	23622248
MIRT042799	hsa-miR-339-5p	CLASH	23622248
MIRT042734	hsa-miR-345-5p	CLASH	23622248
MIRT042734	hsa-miR-345-5p	CLASH	23622248
MIRT040270	hsa-miR-615-3p	CLASH	23622248
MIRT698849	hsa-miR-876-5p	HITS-CLIP	23313552
MIRT698848	hsa-miR-3167	HITS-CLIP	23313552
MIRT698847	hsa-miR-6835-3p	HITS-CLIP	23313552
MIRT698846	hsa-miR-4662a-3p	HITS-CLIP	23313552
MIRT698845	hsa-miR-619-3p	HITS-CLIP	23313552
MIRT698844	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT698843	hsa-miR-875-3p	HITS-CLIP	23313552
MIRT698842	hsa-miR-6128	HITS-CLIP	23313552
MIRT698841	hsa-miR-378j	HITS-CLIP	23313552
MIRT698840	hsa-miR-6839-5p	HITS-CLIP	23313552
MIRT698839	hsa-miR-5186	HITS-CLIP	23313552
MIRT698838	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT698837	hsa-miR-1289	HITS-CLIP	23313552
MIRT698836	hsa-miR-4294	HITS-CLIP	23313552
MIRT698835	hsa-miR-1290	HITS-CLIP	23313552
MIRT698834	hsa-miR-1299	HITS-CLIP	23313552
MIRT698833	hsa-miR-33a-5p	HITS-CLIP	23313552
MIRT698832	hsa-miR-33b-5p	HITS-CLIP	23313552
MIRT698831	hsa-miR-3978	HITS-CLIP	23313552
MIRT698830	hsa-miR-3198	HITS-CLIP	23313552
MIRT698829	hsa-miR-4309	HITS-CLIP	23313552
MIRT698828	hsa-miR-3658	HITS-CLIP	23313552
MIRT698827	hsa-miR-1185-5p	HITS-CLIP	23313552
MIRT698849	hsa-miR-876-5p	HITS-CLIP	23313552
MIRT698848	hsa-miR-3167	HITS-CLIP	23313552
MIRT698847	hsa-miR-6835-3p	HITS-CLIP	23313552
MIRT698846	hsa-miR-4662a-3p	HITS-CLIP	23313552
MIRT698845	hsa-miR-619-3p	HITS-CLIP	23313552
MIRT698844	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT698843	hsa-miR-875-3p	HITS-CLIP	23313552
MIRT698842	hsa-miR-6128	HITS-CLIP	23313552
MIRT698841	hsa-miR-378j	HITS-CLIP	23313552
MIRT698840	hsa-miR-6839-5p	HITS-CLIP	23313552
MIRT698839	hsa-miR-5186	HITS-CLIP	23313552
MIRT698838	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT698837	hsa-miR-1289	HITS-CLIP	23313552
MIRT698836	hsa-miR-4294	HITS-CLIP	23313552
MIRT698835	hsa-miR-1290	HITS-CLIP	23313552
MIRT698834	hsa-miR-1299	HITS-CLIP	23313552
MIRT698833	hsa-miR-33a-5p	HITS-CLIP	23313552
MIRT698832	hsa-miR-33b-5p	HITS-CLIP	23313552
MIRT698831	hsa-miR-3978	HITS-CLIP	23313552
MIRT698830	hsa-miR-3198	HITS-CLIP	23313552
MIRT698829	hsa-miR-4309	HITS-CLIP	23313552
MIRT698828	hsa-miR-3658	HITS-CLIP	23313552
MIRT698827	hsa-miR-1185-5p	HITS-CLIP	23313552
MIRT1392589	hsa-miR-1202	CLIP-seq
MIRT1392590	hsa-miR-1253	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT1392593	hsa-miR-2278	CLIP-seq
MIRT1392594	hsa-miR-3065-3p	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT1392596	hsa-miR-3194-5p	CLIP-seq
MIRT1392597	hsa-miR-33a	CLIP-seq
MIRT1392598	hsa-miR-33b	CLIP-seq
MIRT1392599	hsa-miR-3677-5p	CLIP-seq
MIRT1392600	hsa-miR-3926	CLIP-seq
MIRT1392601	hsa-miR-3942-5p	CLIP-seq
MIRT1392602	hsa-miR-3972	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT1392604	hsa-miR-4436b-3p	CLIP-seq
MIRT1392605	hsa-miR-4661-3p	CLIP-seq
MIRT1392606	hsa-miR-4691-5p	CLIP-seq
MIRT1392607	hsa-miR-4703-5p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392609	hsa-miR-4768-3p	CLIP-seq
MIRT1392610	hsa-miR-4796-3p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT1392612	hsa-miR-548s	CLIP-seq
MIRT1392613	hsa-miR-579	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392615	hsa-miR-665	CLIP-seq
MIRT2117777	hsa-miR-1254	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT2117778	hsa-miR-205	CLIP-seq
MIRT1392593	hsa-miR-2278	CLIP-seq
MIRT2117779	hsa-miR-3116	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT2117780	hsa-miR-3158-3p	CLIP-seq
MIRT2117781	hsa-miR-3689a-3p	CLIP-seq
MIRT2117782	hsa-miR-3689c	CLIP-seq
MIRT2117783	hsa-miR-3910	CLIP-seq
MIRT2117784	hsa-miR-3922-5p	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT1392604	hsa-miR-4436b-3p	CLIP-seq
MIRT2117785	hsa-miR-4446-3p	CLIP-seq
MIRT2117786	hsa-miR-4492	CLIP-seq
MIRT2117787	hsa-miR-4498	CLIP-seq
MIRT1392605	hsa-miR-4661-3p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392609	hsa-miR-4768-3p	CLIP-seq
MIRT1392610	hsa-miR-4796-3p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT2117788	hsa-miR-548an	CLIP-seq
MIRT2117789	hsa-miR-578	CLIP-seq
MIRT1392613	hsa-miR-579	CLIP-seq
MIRT2117790	hsa-miR-619	CLIP-seq
MIRT2117791	hsa-miR-635	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392615	hsa-miR-665	CLIP-seq
MIRT2117792	hsa-miR-762	CLIP-seq
MIRT2117777	hsa-miR-1254	CLIP-seq
MIRT2339745	hsa-miR-125a-5p	CLIP-seq
MIRT2339746	hsa-miR-125b	CLIP-seq
MIRT2339747	hsa-miR-1273d	CLIP-seq
MIRT2339748	hsa-miR-1912	CLIP-seq
MIRT2117779	hsa-miR-3116	CLIP-seq
MIRT2339749	hsa-miR-3123	CLIP-seq
MIRT2339750	hsa-miR-365	CLIP-seq
MIRT2117781	hsa-miR-3689a-3p	CLIP-seq
MIRT2117782	hsa-miR-3689c	CLIP-seq
MIRT2339751	hsa-miR-4319	CLIP-seq
MIRT2339752	hsa-miR-4324	CLIP-seq
MIRT2339753	hsa-miR-4684-5p	CLIP-seq
MIRT2117789	hsa-miR-578	CLIP-seq
MIRT2117791	hsa-miR-635	CLIP-seq
MIRT2339754	hsa-miR-942	CLIP-seq
MIRT1392589	hsa-miR-1202	CLIP-seq
MIRT2339745	hsa-miR-125a-5p	CLIP-seq
MIRT2339746	hsa-miR-125b	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT1392594	hsa-miR-3065-3p	CLIP-seq
MIRT2339749	hsa-miR-3123	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT1392596	hsa-miR-3194-5p	CLIP-seq
MIRT2117783	hsa-miR-3910	CLIP-seq
MIRT2117784	hsa-miR-3922-5p	CLIP-seq
MIRT1392601	hsa-miR-3942-5p	CLIP-seq
MIRT1392602	hsa-miR-3972	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT2339751	hsa-miR-4319	CLIP-seq
MIRT2339752	hsa-miR-4324	CLIP-seq
MIRT1392607	hsa-miR-4703-5p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT2117788	hsa-miR-548an	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392590	hsa-miR-1253	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT2117778	hsa-miR-205	CLIP-seq
MIRT1392593	hsa-miR-2278	CLIP-seq
MIRT2692047	hsa-miR-2467-5p	CLIP-seq
MIRT1392594	hsa-miR-3065-3p	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT2117780	hsa-miR-3158-3p	CLIP-seq
MIRT2692048	hsa-miR-3173-3p	CLIP-seq
MIRT1392597	hsa-miR-33a	CLIP-seq
MIRT1392598	hsa-miR-33b	CLIP-seq
MIRT1392599	hsa-miR-3677-5p	CLIP-seq
MIRT2117783	hsa-miR-3910	CLIP-seq
MIRT2117784	hsa-miR-3922-5p	CLIP-seq
MIRT1392600	hsa-miR-3926	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT1392604	hsa-miR-4436b-3p	CLIP-seq
MIRT2117785	hsa-miR-4446-3p	CLIP-seq
MIRT2117786	hsa-miR-4492	CLIP-seq
MIRT2117787	hsa-miR-4498	CLIP-seq
MIRT1392605	hsa-miR-4661-3p	CLIP-seq
MIRT2692049	hsa-miR-4695-5p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392609	hsa-miR-4768-3p	CLIP-seq
MIRT2692050	hsa-miR-4771	CLIP-seq
MIRT1392610	hsa-miR-4796-3p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT2117788	hsa-miR-548an	CLIP-seq
MIRT1392612	hsa-miR-548s	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392615	hsa-miR-665	CLIP-seq
MIRT2117792	hsa-miR-762	CLIP-seq

Show/Hide all(5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	18724357
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006613	Process	Cotranslational protein targeting to membrane	TAS	7789174
GO:0016021	Component	Integral component of membrane	IEA

MIM	HGNC	e!Ensembl
600867	11324	ENSG00000163479

Protein

UniProt ID

P43308

Protein name

Translocon-associated protein subunit beta (TRAP-beta) (Signal sequence receptor subunit beta) (SSR-beta)

Protein function

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

PDB

8B6L

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05753	TRAP_beta	3 → 181		Family

Sequence

MRLLSFVVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELS
DDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPV
VIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKT
KKN

Sequence length

183

Interactions

View interactions

	KEGG
	Protein processing in endoplasmic reticulum

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881

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