SREBF1 (sterol regulatory element binding transcription factor 1)

Gene

• Entrez ID: 6720
• Gene name: Sterol regulatory element binding transcription factor 1
• Gene symbol: SREBF1
• Synonyms: HMD, IFAP2, SREBP1, bHLHd1
• Chromosome: 17
• Chromosome location: 17p11.2
• Summary: This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes inv

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018325	hsa-miR-335-5p	Microarray	18185580
MIRT051418	hsa-let-7e-5p	CLASH	23622248
MIRT050226	hsa-miR-25-3p	CLASH	23622248
MIRT047574	hsa-miR-10a-5p	CLASH	23622248
MIRT045315	hsa-miR-185-5p	CLASH	23622248
MIRT043859	hsa-miR-378a-3p	CLASH	23622248
MIRT041670	hsa-miR-484	CLASH	23622248
MIRT038739	hsa-miR-93-3p	CLASH	23622248
MIRT037474	hsa-miR-744-5p	CLASH	23622248
MIRT054225	hsa-miR-128-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23990020
MIRT054225	hsa-miR-128-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23990020
MIRT054666	hsa-miR-33a-5p	qRT-PCR, Western blot	24300912
MIRT045315	hsa-miR-185-5p	Luciferase reporter assay, qRT-PCR, Western blot	23951060
MIRT438066	hsa-miR-342-3p	Luciferase reporter assay, qRT-PCR, Western blot	23951060
MIRT045315	hsa-miR-185-5p	Luciferase reporter assay, qRT-PCR, Western blot	23951060
MIRT438066	hsa-miR-342-3p	Luciferase reporter assay, qRT-PCR, Western blot	23951060
MIRT721601	hsa-miR-495-3p	HITS-CLIP	19536157
MIRT721600	hsa-miR-5688	HITS-CLIP	19536157
MIRT721599	hsa-miR-7-1-3p	HITS-CLIP	19536157
MIRT721598	hsa-miR-7-2-3p	HITS-CLIP	19536157
MIRT721597	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT721597	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT721596	hsa-miR-4301	HITS-CLIP	19536157
MIRT721595	hsa-miR-4286	HITS-CLIP	19536157
MIRT721594	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT721593	hsa-miR-4290	HITS-CLIP	19536157
MIRT721592	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT721591	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT527532	hsa-miR-95-5p	PAR-CLIP	22012620
MIRT527531	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT487335	hsa-miR-671-5p	PAR-CLIP	23592263
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	23592263
MIRT487333	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487329	hsa-miR-4271	PAR-CLIP	23592263
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT487326	hsa-miR-663b	PAR-CLIP	23592263
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	23592263
MIRT439142	hsa-let-7c-5p	3'LIFE	25074381
MIRT439117	hsa-miR-10b-5p	3'LIFE	25074381
MIRT439142	hsa-let-7c-5p	3'LIFE	25074381
MIRT439117	hsa-miR-10b-5p	3'LIFE	25074381
MIRT721601	hsa-miR-495-3p	HITS-CLIP	19536157
MIRT721600	hsa-miR-5688	HITS-CLIP	19536157
MIRT721599	hsa-miR-7-1-3p	HITS-CLIP	19536157
MIRT721598	hsa-miR-7-2-3p	HITS-CLIP	19536157
MIRT721597	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT721597	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT721596	hsa-miR-4301	HITS-CLIP	19536157
MIRT721595	hsa-miR-4286	HITS-CLIP	19536157
MIRT721594	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT721593	hsa-miR-4290	HITS-CLIP	19536157
MIRT721592	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT721591	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT487335	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT487333	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487329	hsa-miR-4271	PAR-CLIP	20371350
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT487326	hsa-miR-663b	PAR-CLIP	20371350
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	20371350
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	20371350
MIRT527532	hsa-miR-95-5p	PAR-CLIP	22012620
MIRT527531	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT487338	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT487337	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT487336	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT487335	hsa-miR-671-5p	PAR-CLIP	23592263
MIRT487334	hsa-miR-4743-5p	PAR-CLIP	23592263
MIRT487333	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487332	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487331	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487330	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487329	hsa-miR-4271	PAR-CLIP	23592263
MIRT487327	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT487328	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT487326	hsa-miR-663b	PAR-CLIP	23592263
MIRT487325	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT487324	hsa-miR-4474-3p	PAR-CLIP	23592263
MIRT1387947	hsa-miR-1323	CLIP-seq
MIRT1387948	hsa-miR-142-5p	CLIP-seq
MIRT1387949	hsa-miR-18a	CLIP-seq
MIRT1387950	hsa-miR-18b	CLIP-seq
MIRT1387951	hsa-miR-296-5p	CLIP-seq
MIRT1387952	hsa-miR-3148	CLIP-seq
MIRT1387953	hsa-miR-3173-3p	CLIP-seq
MIRT1387954	hsa-miR-3647-3p	CLIP-seq
MIRT1387955	hsa-miR-4459	CLIP-seq
MIRT1387956	hsa-miR-4698	CLIP-seq
MIRT1387957	hsa-miR-4735-3p	CLIP-seq
MIRT1387958	hsa-miR-4779	CLIP-seq
MIRT1387959	hsa-miR-513c	CLIP-seq
MIRT1387960	hsa-miR-514b-5p	CLIP-seq
MIRT1387961	hsa-miR-548o	CLIP-seq
MIRT1387962	hsa-miR-561	CLIP-seq
MIRT1387963	hsa-miR-1234	CLIP-seq
MIRT1387964	hsa-miR-1275	CLIP-seq
MIRT1387965	hsa-miR-1286	CLIP-seq
MIRT1387947	hsa-miR-1323	CLIP-seq
MIRT1387948	hsa-miR-142-5p	CLIP-seq
MIRT1387949	hsa-miR-18a	CLIP-seq
MIRT1387950	hsa-miR-18b	CLIP-seq
MIRT1387966	hsa-miR-1910	CLIP-seq
MIRT1387967	hsa-miR-2467-3p	CLIP-seq
MIRT1387968	hsa-miR-3158-5p	CLIP-seq
MIRT1387953	hsa-miR-3173-3p	CLIP-seq
MIRT1387969	hsa-miR-330-3p	CLIP-seq
MIRT1387970	hsa-miR-3612	CLIP-seq
MIRT1387954	hsa-miR-3647-3p	CLIP-seq
MIRT1387971	hsa-miR-3678-3p	CLIP-seq
MIRT1387972	hsa-miR-3690	CLIP-seq
MIRT1387973	hsa-miR-377	CLIP-seq
MIRT1387974	hsa-miR-3973	CLIP-seq
MIRT1387975	hsa-miR-4254	CLIP-seq
MIRT1387976	hsa-miR-4297	CLIP-seq
MIRT1387977	hsa-miR-4325	CLIP-seq
MIRT1387978	hsa-miR-4436a	CLIP-seq
MIRT1387979	hsa-miR-4443	CLIP-seq
MIRT1387980	hsa-miR-4446-5p	CLIP-seq
MIRT1387981	hsa-miR-450b-5p	CLIP-seq
MIRT1387982	hsa-miR-4525	CLIP-seq
MIRT1387983	hsa-miR-455-3p	CLIP-seq
MIRT1387984	hsa-miR-4665-3p	CLIP-seq
MIRT1387985	hsa-miR-4665-5p	CLIP-seq
MIRT1387986	hsa-miR-4723-5p	CLIP-seq
MIRT1387987	hsa-miR-4731-5p	CLIP-seq
MIRT1387957	hsa-miR-4735-3p	CLIP-seq
MIRT1387988	hsa-miR-4755-5p	CLIP-seq
MIRT1387989	hsa-miR-4763-5p	CLIP-seq
MIRT1387958	hsa-miR-4779	CLIP-seq
MIRT1387959	hsa-miR-513c	CLIP-seq
MIRT1387960	hsa-miR-514b-5p	CLIP-seq
MIRT1387990	hsa-miR-518a-5p	CLIP-seq
MIRT1387991	hsa-miR-527	CLIP-seq
MIRT1387992	hsa-miR-548an	CLIP-seq
MIRT1387961	hsa-miR-548o	CLIP-seq
MIRT1387993	hsa-miR-550a	CLIP-seq
MIRT1387962	hsa-miR-561	CLIP-seq
MIRT1387994	hsa-miR-625	CLIP-seq
MIRT1387995	hsa-miR-637	CLIP-seq
MIRT1387996	hsa-miR-650	CLIP-seq
MIRT1387963	hsa-miR-1234	CLIP-seq
MIRT1387969	hsa-miR-330-3p	CLIP-seq
MIRT1387976	hsa-miR-4297	CLIP-seq
MIRT1387984	hsa-miR-4665-3p	CLIP-seq
MIRT2116230	hsa-miR-1233	CLIP-seq
MIRT2116231	hsa-miR-150	CLIP-seq
MIRT2116232	hsa-miR-185	CLIP-seq
MIRT2116233	hsa-miR-3065-3p	CLIP-seq
MIRT2116234	hsa-miR-3153	CLIP-seq
MIRT2116235	hsa-miR-326	CLIP-seq
MIRT2116236	hsa-miR-330-5p	CLIP-seq
MIRT1387970	hsa-miR-3612	CLIP-seq
MIRT2116237	hsa-miR-4306	CLIP-seq
MIRT1387979	hsa-miR-4443	CLIP-seq
MIRT2116238	hsa-miR-4487	CLIP-seq
MIRT2116239	hsa-miR-4497	CLIP-seq
MIRT2116240	hsa-miR-4644	CLIP-seq
MIRT2116241	hsa-miR-4667-5p	CLIP-seq
MIRT2116242	hsa-miR-4695-5p	CLIP-seq
MIRT2116243	hsa-miR-4700-5p	CLIP-seq
MIRT2116244	hsa-miR-4713-5p	CLIP-seq
MIRT2116245	hsa-miR-4757-5p	CLIP-seq
MIRT2116246	hsa-miR-486-3p	CLIP-seq
MIRT1387995	hsa-miR-637	CLIP-seq
MIRT1387996	hsa-miR-650	CLIP-seq
MIRT2116247	hsa-miR-662	CLIP-seq
MIRT2338765	hsa-miR-1236	CLIP-seq
MIRT1387947	hsa-miR-1323	CLIP-seq
MIRT2116233	hsa-miR-3065-3p	CLIP-seq
MIRT2338766	hsa-miR-3137	CLIP-seq
MIRT1387952	hsa-miR-3148	CLIP-seq
MIRT2338767	hsa-miR-3183	CLIP-seq
MIRT2338768	hsa-miR-339-5p	CLIP-seq
MIRT2338769	hsa-miR-4257	CLIP-seq
MIRT1387976	hsa-miR-4297	CLIP-seq
MIRT2338770	hsa-miR-4421	CLIP-seq
MIRT1387955	hsa-miR-4459	CLIP-seq
MIRT2338771	hsa-miR-4672	CLIP-seq
MIRT2338772	hsa-miR-4723-3p	CLIP-seq
MIRT2338773	hsa-miR-486-5p	CLIP-seq
MIRT1387959	hsa-miR-513c	CLIP-seq
MIRT1387960	hsa-miR-514b-5p	CLIP-seq
MIRT1387961	hsa-miR-548o	CLIP-seq
MIRT2338774	hsa-miR-670	CLIP-seq
MIRT2395152	hsa-miR-4649-3p	CLIP-seq
MIRT2116230	hsa-miR-1233	CLIP-seq
MIRT1387963	hsa-miR-1234	CLIP-seq
MIRT2632205	hsa-miR-1289	CLIP-seq
MIRT2116231	hsa-miR-150	CLIP-seq
MIRT2116232	hsa-miR-185	CLIP-seq
MIRT2116234	hsa-miR-3153	CLIP-seq
MIRT2632206	hsa-miR-3173-5p	CLIP-seq
MIRT2632207	hsa-miR-3198	CLIP-seq
MIRT2116235	hsa-miR-326	CLIP-seq
MIRT2116236	hsa-miR-330-5p	CLIP-seq
MIRT2632208	hsa-miR-4270	CLIP-seq
MIRT2632209	hsa-miR-4294	CLIP-seq
MIRT2116237	hsa-miR-4306	CLIP-seq
MIRT2632210	hsa-miR-4309	CLIP-seq
MIRT2632211	hsa-miR-4327	CLIP-seq
MIRT2632212	hsa-miR-4441	CLIP-seq
MIRT2632213	hsa-miR-4480	CLIP-seq
MIRT2116239	hsa-miR-4497	CLIP-seq
MIRT2116240	hsa-miR-4644	CLIP-seq
MIRT2116241	hsa-miR-4667-5p	CLIP-seq
MIRT2116243	hsa-miR-4700-5p	CLIP-seq
MIRT2632214	hsa-miR-4704-5p	CLIP-seq
MIRT2116244	hsa-miR-4713-5p	CLIP-seq
MIRT2632215	hsa-miR-4715-5p	CLIP-seq
MIRT2116245	hsa-miR-4757-5p	CLIP-seq
MIRT2632216	hsa-miR-4785	CLIP-seq
MIRT2116246	hsa-miR-486-3p	CLIP-seq
MIRT1387995	hsa-miR-637	CLIP-seq
MIRT2116247	hsa-miR-662	CLIP-seq
MIRT2116230	hsa-miR-1233	CLIP-seq
MIRT1387963	hsa-miR-1234	CLIP-seq
MIRT2632205	hsa-miR-1289	CLIP-seq
MIRT2116231	hsa-miR-150	CLIP-seq
MIRT2116232	hsa-miR-185	CLIP-seq
MIRT2116234	hsa-miR-3153	CLIP-seq
MIRT2632206	hsa-miR-3173-5p	CLIP-seq
MIRT2632207	hsa-miR-3198	CLIP-seq
MIRT2116235	hsa-miR-326	CLIP-seq
MIRT2116236	hsa-miR-330-5p	CLIP-seq
MIRT2632208	hsa-miR-4270	CLIP-seq
MIRT2632209	hsa-miR-4294	CLIP-seq
MIRT2116237	hsa-miR-4306	CLIP-seq
MIRT2632210	hsa-miR-4309	CLIP-seq
MIRT2632211	hsa-miR-4327	CLIP-seq
MIRT2632212	hsa-miR-4441	CLIP-seq
MIRT2632213	hsa-miR-4480	CLIP-seq
MIRT2116239	hsa-miR-4497	CLIP-seq
MIRT2116240	hsa-miR-4644	CLIP-seq
MIRT2116241	hsa-miR-4667-5p	CLIP-seq
MIRT2116243	hsa-miR-4700-5p	CLIP-seq
MIRT2632214	hsa-miR-4704-5p	CLIP-seq
MIRT2116244	hsa-miR-4713-5p	CLIP-seq
MIRT2632215	hsa-miR-4715-5p	CLIP-seq
MIRT2116245	hsa-miR-4757-5p	CLIP-seq
MIRT2632216	hsa-miR-4785	CLIP-seq
MIRT2116246	hsa-miR-486-3p	CLIP-seq
MIRT1387995	hsa-miR-637	CLIP-seq
MIRT2116247	hsa-miR-662	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Activation	20179320
SP1	Unknown	15462672

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	23610160
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0003062	Process	Regulation of heart rate by chemical signal	IEA
GO:0003677	Function	DNA binding	ISS
GO:0003682	Function	Chromatin binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	16407292
GO:0004879	Function	Nuclear receptor activity	IDA	23610160
GO:0005515	Function	Protein binding	IPI	14701856, 16713569, 21993218, 23610160, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	15358760
GO:0005635	Component	Nuclear envelope	TAS	8156598
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006629	Process	Lipid metabolic process	TAS	8156598
GO:0007568	Process	Aging	IEA
GO:0007623	Process	Circadian rhythm	TAS
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0008286	Process	Insulin receptor signaling pathway	IEA
GO:0008610	Process	Lipid biosynthetic process	ISS
GO:0009267	Process	Cellular response to starvation	ISS	16407292
GO:0009749	Process	Response to glucose	IEA
GO:0010867	Process	Positive regulation of triglyceride biosynthetic process	ISS
GO:0010876	Process	Lipid localization	IEA
GO:0010883	Process	Regulation of lipid storage	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0019217	Process	Regulation of fatty acid metabolic process	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0030324	Process	Lung development	IEA
GO:0030522	Process	Intracellular receptor signaling pathway	IEA
GO:0031065	Process	Positive regulation of histone deacetylation	IEA
GO:0031647	Process	Regulation of protein stability	IMP	24912190
GO:0032094	Process	Response to food	IEA
GO:0032526	Process	Response to retinoic acid	IEA
GO:0032570	Process	Response to progesterone	IEA
GO:0032810	Function	Sterol response element binding	IDA	16407292
GO:0032933	Process	SREBP signaling pathway	IDA	27614840
GO:0032933	Process	SREBP signaling pathway	IMP	27614840
GO:0032991	Component	Protein-containing complex	IEA
GO:0033762	Process	Response to glucagon	IEA
GO:0042493	Process	Response to drug	IEA
GO:0042789	Process	MRNA transcription by RNA polymerase II	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045444	Process	Fat cell differentiation	IEA
GO:0045471	Process	Response to ethanol	IEA
GO:0045540	Process	Regulation of cholesterol biosynthetic process	TAS
GO:0045542	Process	Positive regulation of cholesterol biosynthetic process	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	26437365
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IGI	23610160
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	TAS	23610160
GO:0046676	Process	Negative regulation of insulin secretion	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0051591	Process	Response to cAMP	IEA
GO:0071398	Process	Cellular response to fatty acid	IEA
GO:1903146	Process	Regulation of autophagy of mitochondrion	IMP	24912190
GO:1903214	Process	Regulation of protein targeting to mitochondrion	IMP	24912190
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 184756
• HGNC: 11289
• e!Ensembl: ENSG00000072310

Protein

• UniProt ID: P36956
• Protein name: Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor
• Protein function: [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentratio
• PDB: 1AM9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00010	HLH	324 → 374	Helix-loop-helix DNA-binding domain	Domain

• Sequence:

  MDEPPFSEAALEQALGEPCDLDAALLTDIEDMLQLINNQDSDFPGLFDPPYAGSGAGGTD
  PASPDTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPGP
  GIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGN
  TQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLL
  QPHFIKADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDA
  EKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKS
  AVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHKSKSLKDLVSACGSGGNTDVLMEGVKTE
  VEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSR
  GMLDRSRLALCTLVFLCLSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRDGPGW
  AQWLLPPVVWLLNGLLVLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQ
  AAQQLWLALRALGRPLPTSHLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRV
  DASASARDAALVYHKLHQLHTMGKHTGGHLTATNLALSALNLAECAGDAVSVATLAEIYV
  AAALRVKTSLPRALHFLTRFFLSSARQACLAQSGSVPPAMQWLCHPVGHRFFVDGDWSVL
  STPWESLYSLAGNPVDPLAQVTQLFREHLLERALNCVTQPNPSPGSADGDKEFSDALGYL
  QLLNSCSDAAGAPAYSFSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPL
  VEHLPRVLQESERPLPRAALHSFKAARALLGCAKAESGPASLTICEKASGYLQDSLATTP
  ASSSIDKAVQLFLCDLLLVVRTSLWRQQQPPAPAPAAQGTSSRPQASALELRGFQRDLSS
  LRRLAQSFRPAMRRVFLHEATARLMAGASPTRTHQLLDRSLRRRAGPGGKGGAVAELEPR
  PTRREHAEALLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGG
  GTTVTSS

• Sequence length: 1147

Pathways

KEGG:

AMPK signaling pathway
Insulin signaling pathway
Insulin resistance
Non-alcoholic fatty liver disease
Alcoholic liver disease

Reactome:

RORA activates gene expression
Regulation of cholesterol biosynthesis by SREBP (SREBF)
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059683
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	22325160
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	10900012
Parkinson disease	Parkinson Disease	rs116074753, rs118203903, rs118203904, rs115735611, rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs74315361, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121917767, rs121918104, rs1589451049, rs104893877, rs104893878, rs283413, rs112176450, rs111290936, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs387906942, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106	21738487
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	18936756

Unknown
Disease name	Disease term	dbSNP ID	References
Fatty liver	Fatty Liver, Steatohepatitis		24469900
Kidney failure	Kidney Failure, Chronic		19878707
Liver carcinoma	Liver carcinoma		21147110, 14563831
Non-alcoholic fatty liver disease	Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis		24633463, 23603006, 23603006, 24633463