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SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6695
Gene nameGene Name - the full gene name approved by the HGNC.
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SPOCK1
SynonymsGene synonyms aliases
SPOCK, TESTICAN, TIC1
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein`s function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be relat
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT735322 hsa-miR-375 RNA-seq, qRT-PCR 32313120
MIRT734956 hsa-miR-130a-3p Western blotting, qRT-PCR 31526129
MIRT736080 hsa-miR-548c-3p Microarray 31498480
MIRT1385071 hsa-miR-1183 CLIP-seq
MIRT1385072 hsa-miR-1253 CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001558 Process Regulation of cell growth NAS 8389704
GO:0001764 Process Neuron migration ISS
GO:0004867 Function Serine-type endopeptidase inhibitor activity NAS 14511383
GO:0004869 Function Cysteine-type endopeptidase inhibitor activity IDA 14511383
GO:0005509 Function Calcium ion binding IDA 9323035
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q08629
Protein name Testican-1 (Protein SPOCK)
Protein function May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07648 Kazal_2
134 180
Kazal-type serine protease inhibitor domain
Domain
PF10591 SPARC_Ca_bdg
195 304
Secreted protein acidic and rich in cysteine Ca binding region
Domain
PF00086 Thyroglobulin_1
313 376
Thyroglobulin type-1 repeat
Domain
Sequence
MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRDKYWNRF
RDDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKG
NVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLCDGPC
PCLPEPEPPKHKAERSACTDKELRNLASRLKDWFGALHEDANRVIKPTSSNTAQGRFDTS
ILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDGKLSNNE
WCYC
FQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDK
YGNELAGSRKQGAVSC
EEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKLRVHTRAV
TEDDEDEDDDKEDEVGYIW
Sequence length 439
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17929269
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 17929269

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