GediPNet logo

SP1 (Sp1 transcription factor)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6667
Gene nameGene Name - the full gene name approved by the HGNC.
Sp1 transcription factor
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SP1
SynonymsGene synonyms aliases
-
ChromosomeChromosome number
12
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.13
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, re
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002403 hsa-miR-27a-3p Western blot 18006846
MIRT000445 hsa-miR-29b-3p qRT-PCR, ChIP, Western blot 20385359
MIRT000445 hsa-miR-29b-3p Luciferase reporter assay 19211935
MIRT004246 hsa-miR-218-5p Immunoblot, Luciferase reporter assay, qRT-PCR 19913496
MIRT000445 hsa-miR-29b-3p Immunoblot, Luciferase reporter assay, qRT-PCR 19913496
Transcription factors
Transcription factor Regulation Reference
ATM Repression 11466608
ATM Unknown 12926986
CDX2 Unknown 22580340
ESR1 Unknown 19652226
HDAC1 Repression 21636851
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IDA 15831516, 19307576, 21659522, 27030318
GO:0000785 Component Chromatin ISA
GO:0000791 Component Euchromatin IDA 14701757
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 18293083, 18850004
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 14979875
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P08047
Protein name Transcription factor Sp1
Protein function Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of pr
PDB 1SP1 , 1SP2 , 1VA1 , 1VA2 , 1VA3 , 6PV0 , 6PV1 , 6PV2 , 6PV3 , 6UCO , 6UCP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2
626 650
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
656 680
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
686 708
Zinc finger, C2H2 type
Domain
Sequence
MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSTGGGGQESQPSP
LALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTS
KEQSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQ
TVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQG
LANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVT
SGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTPQRVS
GLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPL
SGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQ
TITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTS
GIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTR
REACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTW
SYCGKRFTRSDELQRHKRTH
TGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALS
VGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINI
SGNGF
Sequence length 785
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Endocrine resistance
Mitophagy - animal
TGF-beta signaling pathway
Estrogen signaling pathway
Cortisol synthesis and secretion
Parathyroid hormone synthesis, secretion and action
Cushing syndrome
Huntington disease
Spinocerebellar ataxia
Human cytomegalovirus infection
Pathways in cancer
Transcriptional misregulation in cancer
Breast cancer
Choline metabolism in cancer
Diabetic cardiomyopathy
  PPARA activates gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Activation of gene expression by SREBF (SREBP)
Oncogene Induced Senescence
RNA polymerase II transcribes snRNA genes
Estrogen-dependent gene expression
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia, Chronic schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 23941741, 23540600, 17786189, 25175639
Unknown
Disease name Disease term dbSNP ID References
Hyperglycemia Hyperglycemia 11696579
Nonorganic psychosis Nonorganic psychosis 23941741
Progressive supranuclear palsy Progressive supranuclear palsy 30089514
Psychosis Psychotic Disorders 23941741

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412