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BNIP3L (BCL2 interacting protein 3 like)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
665
Gene nameGene Name - the full gene name approved by the HGNC.
BCL2 interacting protein 3 like
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
BNIP3L
SynonymsGene synonyms aliases
BNIP3a, NIP3L, NIX
ChromosomeChromosome number
8
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p21.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003359 hsa-miR-221-3p Reporter assay;Western blot;qRT-PCR;Microarray 20018759
MIRT052472 hsa-let-7a-5p CLASH 23622248
MIRT052099 hsa-let-7b-5p CLASH 23622248
MIRT054568 hsa-miR-137 Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 24573672
MIRT054568 hsa-miR-137 Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 24573672
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 9973195, 10381623, 16189514, 19060904, 20200478, 21264221, 21516116, 22645275, 24316735, 24981860, 25416956, 25910212, 27107012, 28514442, 31515488, 32296183
GO:0005521 Function Lamin binding IDA 10381623
GO:0005521 Function Lamin binding IPI 10381623
GO:0005634 Component Nucleus IBA 21873635
GO:0005635 Component Nuclear envelope IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O60238
Protein name BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L)
Protein function Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitoc
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06553 BNIP3
17 218
BNIP3
Family
Sequence
Sequence length 219
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Mitophagy - animal   TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 28991256, 26198764, 30285260, 31374203
Unknown
Disease name Disease term dbSNP ID References
Impaired cognition Impaired cognition 26252872

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