Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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665 |
Gene nameGene Name - the full gene name approved by the HGNC.
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BCL2 interacting protein 3 like |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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BNIP3L |
SynonymsGene synonyms aliases
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BNIP3a, NIP3L, NIX |
ChromosomeChromosome number
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8 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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8p21.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0005515 |
Function |
Protein binding |
IPI |
9973195, 10381623, 16189514, 19060904, 20200478, 21264221, 21516116, 22645275, 24316735, 24981860, 25416956, 25910212, 27107012, 28514442, 31515488, 32296183 |
GO:0005521 |
Function |
Lamin binding |
IDA |
10381623 |
GO:0005521 |
Function |
Lamin binding |
IPI |
10381623 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005635 |
Component |
Nuclear envelope |
IBA |
21873635 |
GO:0005635 |
Component |
Nuclear envelope |
IDA |
10381623 |
GO:0005739 |
Component |
Mitochondrion |
IDA |
9973195, 10381623 |
GO:0005741 |
Component |
Mitochondrial outer membrane |
IBA |
21873635 |
GO:0005741 |
Component |
Mitochondrial outer membrane |
IMP |
21264228 |
GO:0005741 |
Component |
Mitochondrial outer membrane |
TAS |
|
GO:0005783 |
Component |
Endoplasmic reticulum |
IBA |
21873635 |
GO:0005783 |
Component |
Endoplasmic reticulum |
IDA |
10381623 |
GO:0005829 |
Component |
Cytosol |
IEA |
|
GO:0010917 |
Process |
Negative regulation of mitochondrial membrane potential |
IEA |
|
GO:0016021 |
Component |
Integral component of membrane |
IEA |
|
GO:0016032 |
Process |
Viral process |
IEA |
|
GO:0016239 |
Process |
Positive regulation of macroautophagy |
IGI |
19273585 |
GO:0016607 |
Component |
Nuclear speck |
IDA |
|
GO:0031224 |
Component |
Intrinsic component of membrane |
TAS |
10381623 |
GO:0035694 |
Process |
Mitochondrial protein catabolic process |
IMP |
21264228 |
GO:0042802 |
Function |
Identical protein binding |
IPI |
10381623, 16189514, 21516116, 25416956, 27107012 |
GO:0042803 |
Function |
Protein homodimerization activity |
IDA |
10381623 |
GO:0042981 |
Process |
Regulation of apoptotic process |
TAS |
|
GO:0043065 |
Process |
Positive regulation of apoptotic process |
IDA |
9973195 |
GO:0043066 |
Process |
Negative regulation of apoptotic process |
IDA |
10381623 |
GO:0043067 |
Process |
Regulation of programmed cell death |
IBA |
21873635 |
GO:0051607 |
Process |
Defense response to virus |
IBA |
21873635 |
GO:0051607 |
Process |
Defense response to virus |
IDA |
9973195 |
GO:0060548 |
Process |
Negative regulation of cell death |
IGI |
19273585 |
GO:0071456 |
Process |
Cellular response to hypoxia |
IGI |
19273585 |
GO:0097345 |
Process |
Mitochondrial outer membrane permeabilization |
IBA |
21873635 |
GO:1903146 |
Process |
Regulation of autophagy of mitochondrion |
IEA |
|
GO:1903214 |
Process |
Regulation of protein targeting to mitochondrion |
IEA |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
O60238 |
Protein name |
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) |
Protein function |
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitoc |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF06553 |
BNIP3 |
17 → 218 |
BNIP3 |
Family |
|
Sequence |
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Sequence length |
219 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
28991256, 26198764, 30285260, 31374203 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Impaired cognition |
Impaired cognition |
|
26252872 |
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