STK33 (serine/threonine kinase 33)

Gene

• Entrez ID: 65975
• Gene name: Serine/threonine kinase 33
• Gene symbol: STK33
• Synonyms: SPGF93
• Chromosome: 11
• Chromosome location: 11p15.4

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1057520013	A>C	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025022	hsa-miR-183-5p	Sequencing	20371350
MIRT027202	hsa-miR-103a-3p	Sequencing	20371350
MIRT032007	hsa-miR-16-5p	Sequencing	20371350
MIRT047404	hsa-miR-10b-5p	CLASH	23622248
MIRT037139	hsa-miR-877-3p	CLASH	23622248
MIRT1397712	hsa-miR-2054	CLIP-seq
MIRT1397713	hsa-miR-219-1-3p	CLIP-seq
MIRT1397714	hsa-miR-3177-5p	CLIP-seq
MIRT1397715	hsa-miR-3692	CLIP-seq
MIRT1397716	hsa-miR-4436b-5p	CLIP-seq
MIRT1397717	hsa-miR-4718	CLIP-seq
MIRT1397718	hsa-miR-526b	CLIP-seq
MIRT1397719	hsa-miR-571	CLIP-seq
MIRT2635388	hsa-miR-183	CLIP-seq
MIRT1397712	hsa-miR-2054	CLIP-seq
MIRT2635389	hsa-miR-31	CLIP-seq
MIRT2635390	hsa-miR-4263	CLIP-seq
MIRT1397717	hsa-miR-4718	CLIP-seq
MIRT2635391	hsa-miR-4775	CLIP-seq
MIRT2635392	hsa-miR-576-5p	CLIP-seq
MIRT2635393	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0042770	Process	Signal transduction in response to DNA damage	IBA	21873635
GO:0044773	Process	Mitotic DNA damage checkpoint	IBA	21873635
GO:0046777	Process	Protein autophosphorylation	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA

Other IDs

• MIM: 607670
• HGNC: 14568
• e!Ensembl: ENSG00000130413

Protein

• UniProt ID: Q9BYT3
• Protein name: Serine/threonine-protein kinase 33 (EC 2.7.11.1)
• Protein function: Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 a
• PDB: 8VF6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	116 → 381	Protein kinase domain	Domain

• Sequence:

  MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERK
  KEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGR
  ILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQ
  VFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLK
  LENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDY
  SQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQ
  LMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPS
  TEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAE
  IKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL

• Sequence length: 514

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Small cell carcinoma of lung, Large cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	28604730

Unknown
Disease name	Disease term	dbSNP ID	References
Pancreatic neoplasm	Pancreatic Neoplasm		20581473