SLC18A1 (solute carrier family 18 member A1)

Gene

• Entrez ID: 6570
• Gene name: Solute carrier family 18 member A1
• Gene symbol: SLC18A1
• Synonyms: CGAT, VAT1, VMAT1
• Chromosome: 8
• Chromosome location: 8p21.3
• Summary: The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2104638	hsa-miR-4778-3p	CLIP-seq
MIRT2329112	hsa-miR-3153	CLIP-seq
MIRT2329113	hsa-miR-4505	CLIP-seq
MIRT2329114	hsa-miR-4638-5p	CLIP-seq
MIRT2329115	hsa-miR-4646-5p	CLIP-seq
MIRT2329116	hsa-miR-4668-5p	CLIP-seq
MIRT2329117	hsa-miR-513c	CLIP-seq
MIRT2329118	hsa-miR-514b-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005335	Function	Serotonin:sodium symporter activity	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0008504	Function	Monoamine transmembrane transporter activity	TAS	8643547
GO:0015842	Process	Aminergic neurotransmitter loading into synaptic vesicle	IBA	21873635
GO:0015844	Process	Monoamine transport	TAS	8643547
GO:0016021	Component	Integral component of membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IBA	21873635
GO:0030672	Component	Synaptic vesicle membrane	IBA	21873635
GO:0042908	Process	Xenobiotic transport	IEA
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IEA
GO:0043195	Component	Terminal bouton	IBA	21873635
GO:0051610	Process	Serotonin uptake	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070083	Component	Clathrin-sculpted monoamine transport vesicle membrane	TAS

Other IDs

• MIM: 193002
• HGNC: 10934
• e!Ensembl: ENSG00000036565

Protein

• UniProt ID: P54219
• Protein name: Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1)
• Protein function: [Isoform 1]: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATP
• PDB: 8TGG, 8TGH, 8TGI, 8TGJ, 8TGK, 8TGL, 8TGM, 8TGN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07690	MFS_1	96 → 433	Major Facilitator Superfamily	Family

• Sequence:

  MLRTILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSS
  LHLGHAGSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISA
  HKNNCLQGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLS
  TVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGL
  LVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLKDP
  YILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLA
  NKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDL
  RHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRS
  PPAKEEKLAILSQDCPMETRMYATQKPTKEFPLGEDSDEEPDHEE

• Sequence length: 525

Pathways

KEGG:

Synaptic vesicle cycle
Serotonergic synapse
Dopaminergic synapse
Parkinson disease
Cocaine addiction
Amphetamine addiction
Alcoholism

Reactome:

Na+/Cl- dependent neurotransmitter transporters

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	18451639

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		18249496, 19204725, 16936705, 20419435
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	19204725