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SLC7A1 (solute carrier family 7 member 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6541
Gene nameGene Name - the full gene name approved by the HGNC.
Solute carrier family 7 member 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SLC7A1
SynonymsGene synonyms aliases
ATRC1, CAT-1, ERR, HCAT1, REC1L
ChromosomeChromosome number
13
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q12.3
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003105 hsa-miR-122-5p Luciferase reporter assay, Western blot 17179747
MIRT003105 hsa-miR-122-5p Luciferase reporter assay, Western blot 17179747
MIRT003105 hsa-miR-122-5p Luciferase reporter assay, Western blot 17179747
MIRT003105 hsa-miR-122-5p Luciferase reporter assay, Western blot 17179747
MIRT003105 hsa-miR-122-5p Luciferase reporter assay, Western blot 17179747
Transcription factors
Transcription factor Regulation Reference
NRIP1 Activation 17056252
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000064 Function L-ornithine transmembrane transporter activity IBA 21873635
GO:0005290 Function L-histidine transmembrane transporter activity IDA 11591158
GO:0005515 Function Protein binding IPI 25416956, 28514442, 30956113, 32296183
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane IDA 28112518
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P30825
Protein name High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter)
Protein function High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13520 AA_permease_2
32 446
Amino acid permease
Family
PF13906 AA_permease_C
558 608
C-terminus of AA_permease
Domain
Sequence
Sequence length 629
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  MicroRNAs in cancer   Amino acid transport across the plasma membrane
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 11401523
Unknown
Disease name Disease term dbSNP ID References
Cardiovascular diseases Cardiovascular Diseases 30595370
Prostatic neoplasms Prostatic Neoplasms 11401523

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