MPPE1 (metallophosphoesterase 1)

Gene

• Entrez ID: 65258
• Gene name: Metallophosphoesterase 1
• Gene symbol: MPPE1
• Synonyms: Cdc1, PGAP5
• Chromosome: 18
• Chromosome location: 18p11.21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027280	hsa-miR-101-3p	Sequencing	20371350
MIRT617099	hsa-miR-5681b	HITS-CLIP	23824327
MIRT617100	hsa-miR-133a-5p	HITS-CLIP	23824327
MIRT617101	hsa-miR-4774-5p	HITS-CLIP	23824327
MIRT617102	hsa-miR-1976	HITS-CLIP	23824327
MIRT617103	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT617104	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT617105	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT617106	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT617107	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT617108	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT642361	hsa-miR-4279	HITS-CLIP	23824327
MIRT642362	hsa-miR-4320	HITS-CLIP	23824327
MIRT661192	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT661193	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT661194	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT661195	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT661196	hsa-miR-1827	HITS-CLIP	23824327
MIRT661197	hsa-miR-4635	HITS-CLIP	23824327
MIRT661198	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT661199	hsa-miR-4478	HITS-CLIP	23824327
MIRT661200	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT661201	hsa-miR-4419b	HITS-CLIP	23824327
MIRT661202	hsa-miR-3929	HITS-CLIP	23824327
MIRT661203	hsa-miR-940	HITS-CLIP	23824327
MIRT661204	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT661205	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT661206	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT708297	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT708298	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT708299	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT708300	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT708301	hsa-miR-1290	HITS-CLIP	19536157
MIRT708302	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT708303	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT708304	hsa-miR-7113-5p	HITS-CLIP	19536157
MIRT708305	hsa-miR-6822-5p	HITS-CLIP	19536157
MIRT708306	hsa-miR-6750-5p	HITS-CLIP	19536157
MIRT708307	hsa-miR-6753-5p	HITS-CLIP	19536157
MIRT763702	hsa-miR-203b-3p	PAR-CLIP	27292025
MIRT766331	hsa-miR-3653-3p	PAR-CLIP	27292025
MIRT766429	hsa-miR-3658	PAR-CLIP	27292025
MIRT769734	hsa-miR-4494	PAR-CLIP	27292025
MIRT783060	hsa-miR-106a-5p	HITS-CLIP	27418678
MIRT783073	hsa-miR-106b-5p	HITS-CLIP	27418678
MIRT783196	hsa-miR-1245a	HITS-CLIP	27418678
MIRT783883	hsa-miR-150-5p	HITS-CLIP	27418678
MIRT783936	hsa-miR-17-5p	HITS-CLIP	27418678
MIRT783987	hsa-miR-186-3p	HITS-CLIP	27418678
MIRT784175	hsa-miR-20a-5p	HITS-CLIP	27418678
MIRT784189	hsa-miR-20b-5p	HITS-CLIP	27418678
MIRT784424	hsa-miR-302a-3p	HITS-CLIP	27418678
MIRT784435	hsa-miR-302b-3p	HITS-CLIP	27418678
MIRT784447	hsa-miR-302c-3p	HITS-CLIP	27418678
MIRT784462	hsa-miR-302d-3p	HITS-CLIP	27418678
MIRT784473	hsa-miR-302e	HITS-CLIP	27418678
MIRT785316	hsa-miR-372-3p	HITS-CLIP	27418678
MIRT785333	hsa-miR-373-3p	HITS-CLIP	27418678
MIRT785467	hsa-miR-3934-5p	HITS-CLIP	27418678
MIRT786554	hsa-miR-4731-5p	HITS-CLIP	27418678
MIRT787077	hsa-miR-5089-5p	HITS-CLIP	27418678
MIRT787087	hsa-miR-5095	HITS-CLIP	27418678
MIRT787132	hsa-miR-512-3p	HITS-CLIP	27418678
MIRT787242	hsa-miR-519d-3p	HITS-CLIP	27418678
MIRT787258	hsa-miR-520a-3p	HITS-CLIP	27418678
MIRT787270	hsa-miR-520b	HITS-CLIP	27418678
MIRT787281	hsa-miR-520c-3p	HITS-CLIP	27418678
MIRT787294	hsa-miR-520d-3p	HITS-CLIP	27418678
MIRT787308	hsa-miR-520e	HITS-CLIP	27418678
MIRT787321	hsa-miR-520g-3p	HITS-CLIP	27418678
MIRT787331	hsa-miR-520h	HITS-CLIP	27418678
MIRT787353	hsa-miR-526b-3p	HITS-CLIP	27418678
MIRT787623	hsa-miR-552-3p	HITS-CLIP	27418678
MIRT787696	hsa-miR-5589-5p	HITS-CLIP	27418678
MIRT788115	hsa-miR-619-5p	HITS-CLIP	27418678
MIRT788170	hsa-miR-640	HITS-CLIP	27418678
MIRT788241	hsa-miR-6504-3p	HITS-CLIP	27418678
MIRT788256	hsa-miR-6506-5p	HITS-CLIP	27418678
MIRT788673	hsa-miR-6778-3p	HITS-CLIP	27418678
MIRT788858	hsa-miR-6807-5p	HITS-CLIP	27418678
MIRT789429	hsa-miR-7151-3p	HITS-CLIP	27418678
MIRT789815	hsa-miR-8079	HITS-CLIP	27418678
MIRT789972	hsa-miR-93-5p	HITS-CLIP	27418678

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005654	Component	Nucleoplasm	IDA
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	ISS
GO:0005794	Component	Golgi apparatus	IDA
GO:0005801	Component	Cis-Golgi network	ISS
GO:0006506	Process	GPI anchor biosynthetic process	IMP	29374258
GO:0006506	Process	GPI anchor biosynthetic process	ISS
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	ISS
GO:0016021	Component	Integral component of membrane	IEA
GO:0030145	Function	Manganese ion binding	ISS
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	IEA
GO:0034235	Function	GPI anchor binding	ISS
GO:0062050	Function	GPI-mannose ethanolamine phosphate phosphodiesterase activity	ISS
GO:0070971	Component	Endoplasmic reticulum exit site	ISS

Other IDs

• MIM: 611900
• HGNC: 15988
• e!Ensembl: ENSG00000154889

Protein

• UniProt ID: Q53F39
• Protein name: Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5)
• Protein function: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00149	Metallophos	70 → 307	Calcineurin-like phosphoesterase	Domain

• Sequence:

  MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASD
  GEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDI
  FDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSS
  ERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREARGSSRCGPGPLLP
  TSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVL
  SGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSITPTDYTLSKCYLPREDVVLII
  YCGVVGFLVVLTLTHFGLLASPFLSGLNLLGKRKTR

• Sequence length: 396

Pathways

KEGG:

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Metabolic pathways

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		19859903