MRPS6 (mitochondrial ribosomal protein S6)

Gene

• Entrez ID: 64968
• Gene name: Mitochondrial ribosomal protein S6
• Gene symbol: MRPS6
• Synonyms: C21orf101, MRP-S6, RPMS6, S6mt, bS6m
• Chromosome: 21
• Chromosome location: 21q22.11
• Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050858	hsa-miR-17-5p	CLASH	23622248
MIRT1160477	hsa-miR-1237	CLIP-seq
MIRT1160478	hsa-miR-1248	CLIP-seq
MIRT1160479	hsa-miR-142-5p	CLIP-seq
MIRT1160480	hsa-miR-1915	CLIP-seq
MIRT1160481	hsa-miR-202	CLIP-seq
MIRT1160482	hsa-miR-330-3p	CLIP-seq
MIRT1160483	hsa-miR-340	CLIP-seq
MIRT1160484	hsa-miR-3611	CLIP-seq
MIRT1160485	hsa-miR-3692	CLIP-seq
MIRT1160486	hsa-miR-369-3p	CLIP-seq
MIRT1160487	hsa-miR-374a	CLIP-seq
MIRT1160488	hsa-miR-374b	CLIP-seq
MIRT1160489	hsa-miR-374c	CLIP-seq
MIRT1160490	hsa-miR-382	CLIP-seq
MIRT1160491	hsa-miR-3926	CLIP-seq
MIRT1160492	hsa-miR-3929	CLIP-seq
MIRT1160493	hsa-miR-3941	CLIP-seq
MIRT1160494	hsa-miR-409-5p	CLIP-seq
MIRT1160495	hsa-miR-410	CLIP-seq
MIRT1160496	hsa-miR-4419b	CLIP-seq
MIRT1160497	hsa-miR-4438	CLIP-seq
MIRT1160498	hsa-miR-4459	CLIP-seq
MIRT1160499	hsa-miR-4478	CLIP-seq
MIRT1160500	hsa-miR-4484	CLIP-seq
MIRT1160501	hsa-miR-4643	CLIP-seq
MIRT1160502	hsa-miR-466	CLIP-seq
MIRT1160503	hsa-miR-4661-5p	CLIP-seq
MIRT1160504	hsa-miR-4672	CLIP-seq
MIRT1160505	hsa-miR-4678	CLIP-seq
MIRT1160506	hsa-miR-4717-3p	CLIP-seq
MIRT1160507	hsa-miR-4726-3p	CLIP-seq
MIRT1160508	hsa-miR-4753-5p	CLIP-seq
MIRT1160509	hsa-miR-4772-3p	CLIP-seq
MIRT1160510	hsa-miR-518a-5p	CLIP-seq
MIRT1160511	hsa-miR-527	CLIP-seq
MIRT1160512	hsa-miR-548an	CLIP-seq
MIRT1160513	hsa-miR-548p	CLIP-seq
MIRT1160514	hsa-miR-655	CLIP-seq
MIRT1160515	hsa-miR-665	CLIP-seq
MIRT1160516	hsa-miR-888	CLIP-seq
MIRT1160479	hsa-miR-142-5p	CLIP-seq
MIRT1160483	hsa-miR-340	CLIP-seq
MIRT1160495	hsa-miR-410	CLIP-seq
MIRT2275185	hsa-miR-3117-5p	CLIP-seq
MIRT1160486	hsa-miR-369-3p	CLIP-seq
MIRT1160487	hsa-miR-374a	CLIP-seq
MIRT1160488	hsa-miR-374b	CLIP-seq
MIRT1160489	hsa-miR-374c	CLIP-seq
MIRT1160490	hsa-miR-382	CLIP-seq
MIRT2275186	hsa-miR-570	CLIP-seq
MIRT1160514	hsa-miR-655	CLIP-seq
MIRT2574195	hsa-miR-1205	CLIP-seq
MIRT2574196	hsa-miR-1224-3p	CLIP-seq
MIRT2574197	hsa-miR-217	CLIP-seq
MIRT2574198	hsa-miR-223	CLIP-seq
MIRT2574199	hsa-miR-2355-5p	CLIP-seq
MIRT2574200	hsa-miR-3065-3p	CLIP-seq
MIRT2275185	hsa-miR-3117-5p	CLIP-seq
MIRT2574201	hsa-miR-3665	CLIP-seq
MIRT2574202	hsa-miR-3919	CLIP-seq
MIRT2574203	hsa-miR-4276	CLIP-seq
MIRT2574204	hsa-miR-4286	CLIP-seq
MIRT2574205	hsa-miR-4418	CLIP-seq
MIRT2574206	hsa-miR-4468	CLIP-seq
MIRT2574207	hsa-miR-4697-3p	CLIP-seq
MIRT2574208	hsa-miR-4797-5p	CLIP-seq
MIRT2574209	hsa-miR-509-3-5p	CLIP-seq
MIRT2574210	hsa-miR-509-5p	CLIP-seq
MIRT2574211	hsa-miR-548c-3p	CLIP-seq
MIRT2275186	hsa-miR-570	CLIP-seq
MIRT2574212	hsa-miR-657	CLIP-seq
MIRT2574195	hsa-miR-1205	CLIP-seq
MIRT2574196	hsa-miR-1224-3p	CLIP-seq
MIRT2574197	hsa-miR-217	CLIP-seq
MIRT2574198	hsa-miR-223	CLIP-seq
MIRT2574199	hsa-miR-2355-5p	CLIP-seq
MIRT2574200	hsa-miR-3065-3p	CLIP-seq
MIRT2275185	hsa-miR-3117-5p	CLIP-seq
MIRT2574201	hsa-miR-3665	CLIP-seq
MIRT2574202	hsa-miR-3919	CLIP-seq
MIRT2574203	hsa-miR-4276	CLIP-seq
MIRT2574204	hsa-miR-4286	CLIP-seq
MIRT2574205	hsa-miR-4418	CLIP-seq
MIRT2574206	hsa-miR-4468	CLIP-seq
MIRT2574207	hsa-miR-4697-3p	CLIP-seq
MIRT1160509	hsa-miR-4772-3p	CLIP-seq
MIRT2574208	hsa-miR-4797-5p	CLIP-seq
MIRT2574209	hsa-miR-509-3-5p	CLIP-seq
MIRT2574210	hsa-miR-509-5p	CLIP-seq
MIRT2574211	hsa-miR-548c-3p	CLIP-seq
MIRT2275186	hsa-miR-570	CLIP-seq
MIRT2574212	hsa-miR-657	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	ISS	11402041
GO:0003735	Function	Structural constituent of ribosome	NAS	11279123
GO:0005515	Function	Protein binding	IPI	22458338, 25416956, 32296183
GO:0005739	Component	Mitochondrion	IDA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005763	Component	Mitochondrial small ribosomal subunit	IBA	21873635
GO:0005763	Component	Mitochondrial small ribosomal subunit	IDA	25838379
GO:0005763	Component	Mitochondrial small ribosomal subunit	ISS	11402041
GO:0006412	Process	Translation	NAS	11279123
GO:0015935	Component	Small ribosomal subunit	NAS	11279123
GO:0032543	Process	Mitochondrial translation	ISS	11402041
GO:0070125	Process	Mitochondrial translational elongation	TAS
GO:0070126	Process	Mitochondrial translational termination	TAS
GO:0070181	Function	Small ribosomal subunit rRNA binding	IBA	21873635

Other IDs

• MIM: 611973
• HGNC: 14051
• e!Ensembl: ENSG00000243927

Protein

• UniProt ID: P82932
• Protein name: Small ribosomal subunit protein bS6m (28S ribosomal protein S6, mitochondrial) (MRP-S6) (S6mt)
• PDB: 3J9M, 6NU2, 6NU3, 6RW4, 6RW5, 6VLZ, 6VMI, 6ZM5, 6ZM6, 6ZS9, 6ZSA, 6ZSB, 6ZSC, 6ZSD, 6ZSE, 6ZSG, 7A5F, 7A5G, 7A5I, 7A5K, 7L08, 7OG4, 7P2E, 7PNX, 7PNY, 7PNZ, 7PO0, 7PO1, 7PO2, 7PO3, 7QI4, 7QI5, 7QI6, 8ANY, 8CSP, 8CSQ, 8CSR, 8CSS, 8CST, 8CSU, 8K2A, 8OIR, 8OIS, 8QRK, 8QRL, 8QRM, 8QRN, 8RRI, 8XT0, 8XT2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01250	Ribosomal_S6	3 → 95	Ribosomal protein S6	Domain

• Sequence:

  MPRYELALILKAMQRPETAATLKRTIEALMDRGAIVRDLENLGERALPYRISAHSQQHNR
  GGYFLVDFYAPTAAVESMVEHLSRDIDVIRGNIVKHPLTQELKECEGIVPVPLAEKLYST
  KKRKK

• Sequence length: 125

Pathways

KEGG:

Ribosome

Reactome:

Mitochondrial translation elongation
Mitochondrial translation termination

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	21378990

Unknown
Disease name	Disease term	dbSNP ID	References
Coronary arteriosclerosis	Coronary Arteriosclerosis		21378990