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ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6482
Gene nameGene Name - the full gene name approved by the HGNC.
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ST3GAL1
SynonymsGene synonyms aliases
Gal-NAc6S, SIAT4A, SIATFL, ST3GalA, ST3GalA.1, ST3GalIA, ST3GalIA,1, ST3O
ChromosomeChromosome number
8
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q24.22
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047012 hsa-miR-204-5p CLASH 23622248
MIRT047012 hsa-miR-204-5p CLASH 23622248
MIRT706904 hsa-miR-3664-5p HITS-CLIP 21572407
MIRT706903 hsa-miR-4639-3p HITS-CLIP 21572407
MIRT706902 hsa-miR-1304-3p HITS-CLIP 21572407
Transcription factors
Transcription factor Regulation Reference
MYC Activation 22547830
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0002319 Process Memory B cell differentiation IEA
GO:0003836 Function Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA 21873635
GO:0003836 Function Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA 8027041, 14722111
GO:0003836 Function Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q11201
Protein name CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase)
Protein function A beta-galactoside alpha2->3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:31784620, PubMed:8027041). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide suga
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00777 Glyco_transf_29
83 338
Glycosyltransferase family 29 (sialyltransferase)
Family
Sequence
Sequence length 340
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Mucin type O-glycan biosynthesis
Glycosaminoglycan biosynthesis - keratan sulfate
Glycosphingolipid biosynthesis - globo and isoglobo series
Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways
  Keratan sulfate biosynthesis
Sialic acid metabolism
Termination of O-glycan biosynthesis
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 18180429
Unknown
Disease name Disease term dbSNP ID References
Bipolar disorder Bipolar Disorder 18163389
Frontal fibrosing alopecia Postmenopausal frontal fibrosing alopecia, Frontal fibrosing alopecia 30850646
Nonorganic psychosis Nonorganic psychosis 18180429
Psychosis Psychotic Disorders 18180429

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