CYP3A43 (cytochrome P450 family 3 subfamily A member 43)

Gene

• Entrez ID: 64816
• Gene name: Cytochrome P450 family 3 subfamily A member 43
• Gene symbol: CYP3A43
• Synonyms: -
• Chromosome: 7
• Chromosome location: 7q22.1
• Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protei

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT921536	hsa-miR-1276	CLIP-seq
MIRT921537	hsa-miR-4311	CLIP-seq
MIRT921538	hsa-miR-583	CLIP-seq
MIRT921539	hsa-miR-636	CLIP-seq
MIRT921540	hsa-miR-653	CLIP-seq
MIRT921541	hsa-miR-1286	CLIP-seq
MIRT921542	hsa-miR-200b	CLIP-seq
MIRT921543	hsa-miR-200c	CLIP-seq
MIRT921544	hsa-miR-3617	CLIP-seq
MIRT921545	hsa-miR-369-3p	CLIP-seq
MIRT921546	hsa-miR-374a	CLIP-seq
MIRT921547	hsa-miR-374b	CLIP-seq
MIRT921548	hsa-miR-3913-3p	CLIP-seq
MIRT921549	hsa-miR-429	CLIP-seq
MIRT921550	hsa-miR-4517	CLIP-seq
MIRT921551	hsa-miR-4722-5p	CLIP-seq
MIRT921552	hsa-miR-4793-5p	CLIP-seq
MIRT921553	hsa-miR-4795-3p	CLIP-seq
MIRT921554	hsa-miR-641	CLIP-seq
MIRT921555	hsa-miR-7	CLIP-seq
MIRT921556	hsa-miR-889	CLIP-seq
MIRT2436753	hsa-miR-4457	CLIP-seq
MIRT2436754	hsa-miR-4775	CLIP-seq
MIRT2436755	hsa-miR-513b	CLIP-seq
MIRT2436756	hsa-miR-590-3p	CLIP-seq
MIRT2436753	hsa-miR-4457	CLIP-seq
MIRT2436754	hsa-miR-4775	CLIP-seq
MIRT2436755	hsa-miR-513b	CLIP-seq
MIRT2436756	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004497	Function	Monooxygenase activity	ISS
GO:0004497	Function	Monooxygenase activity	TAS
GO:0005506	Function	Iron ion binding	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0008202	Process	Steroid metabolic process	IBA	21873635
GO:0008395	Function	Steroid hydroxylase activity	IBA	21873635
GO:0020037	Function	Heme binding	IEA
GO:0050649	Function	Testosterone 6-beta-hydroxylase activity	IBA	21873635
GO:0070330	Function	Aromatase activity	IEA
GO:0070989	Process	Oxidative demethylation	IBA	21873635
GO:0101020	Function	Estrogen 16-alpha-hydroxylase activity	IBA	21873635

Other IDs

• MIM: 606534
• HGNC: 17450
• e!Ensembl: ENSG00000021461

Protein

• UniProt ID: Q9HB55
• Protein name: Cytochrome P450 3A43 (EC 1.14.14.1)
• Protein function: Exhibits low testosterone 6-beta-hydroxylase activity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00067	p450	38 → 493	Cytochrome P450	Domain

• Sequence:

  MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
  AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
  MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
  FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
  IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
  NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS
  KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL
  PILQPEKPIVLKVHLRDGITSGP

• Sequence length: 503

Pathways

KEGG:

Chemical carcinogenesis - DNA adducts

Reactome:

Miscellaneous substrates
Xenobiotics

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	15894682

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		15894682