ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1)

Gene

• Entrez ID: 6480
• Gene name: ST6 beta-galactoside alpha-2,6-sialyltransferase 1
• Gene symbol: ST6GAL1
• Synonyms: CDw75, SIAT1, ST6GalI, ST6N
• Chromosome: 3
• Chromosome location: 3q27.3
• Summary: This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006076	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT006076	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT006076	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT017979	hsa-miR-335-5p	Microarray	18185580
MIRT030941	hsa-miR-21-5p	Microarray	18591254
MIRT040947	hsa-miR-18a-3p	CLASH	23622248
MIRT448173	hsa-miR-5009-3p	PAR-CLIP	22100165
MIRT448172	hsa-miR-924	PAR-CLIP	22100165
MIRT448171	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT448170	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT448169	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT448168	hsa-miR-3685	PAR-CLIP	22100165
MIRT448167	hsa-miR-384	PAR-CLIP	22100165
MIRT448165	hsa-miR-8081	PAR-CLIP	22100165
MIRT448173	hsa-miR-5009-3p	PAR-CLIP	22100165
MIRT448172	hsa-miR-924	PAR-CLIP	22100165
MIRT448171	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT448170	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT448169	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT448168	hsa-miR-3685	PAR-CLIP	22100165
MIRT448167	hsa-miR-384	PAR-CLIP	22100165
MIRT448165	hsa-miR-8081	PAR-CLIP	22100165
MIRT030941	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT439531	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT030941	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT439531	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT448173	hsa-miR-5009-3p	PAR-CLIP	22100165
MIRT448172	hsa-miR-924	PAR-CLIP	22100165
MIRT448171	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT448170	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT448169	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT448168	hsa-miR-3685	PAR-CLIP	22100165
MIRT448167	hsa-miR-384	PAR-CLIP	22100165
MIRT448165	hsa-miR-8081	PAR-CLIP	22100165
MIRT448173	hsa-miR-5009-3p	PAR-CLIP	22100165
MIRT448172	hsa-miR-924	PAR-CLIP	22100165
MIRT448171	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT448170	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT448169	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT448168	hsa-miR-3685	PAR-CLIP	22100165
MIRT448167	hsa-miR-384	PAR-CLIP	22100165
MIRT448165	hsa-miR-8081	PAR-CLIP	22100165
MIRT1393652	hsa-miR-1252	CLIP-seq
MIRT1393653	hsa-miR-140-3p	CLIP-seq
MIRT1393654	hsa-miR-148a	CLIP-seq
MIRT1393655	hsa-miR-148b	CLIP-seq
MIRT1393656	hsa-miR-152	CLIP-seq
MIRT1393657	hsa-miR-1825	CLIP-seq
MIRT1393658	hsa-miR-21	CLIP-seq
MIRT1393659	hsa-miR-2355-5p	CLIP-seq
MIRT1393660	hsa-miR-3155	CLIP-seq
MIRT1393661	hsa-miR-3155b	CLIP-seq
MIRT1393662	hsa-miR-3173-3p	CLIP-seq
MIRT1393663	hsa-miR-338-3p	CLIP-seq
MIRT1393664	hsa-miR-3616-5p	CLIP-seq
MIRT1393665	hsa-miR-3647-5p	CLIP-seq
MIRT1393666	hsa-miR-3714	CLIP-seq
MIRT1393667	hsa-miR-3908	CLIP-seq
MIRT1393668	hsa-miR-3942-5p	CLIP-seq
MIRT1393669	hsa-miR-4302	CLIP-seq
MIRT1393670	hsa-miR-4438	CLIP-seq
MIRT1393671	hsa-miR-4476	CLIP-seq
MIRT1393672	hsa-miR-4484	CLIP-seq
MIRT1393673	hsa-miR-4496	CLIP-seq
MIRT1393674	hsa-miR-4509	CLIP-seq
MIRT1393675	hsa-miR-4533	CLIP-seq
MIRT1393676	hsa-miR-4635	CLIP-seq
MIRT1393677	hsa-miR-4703-5p	CLIP-seq
MIRT1393678	hsa-miR-4762-5p	CLIP-seq
MIRT1393679	hsa-miR-4766-3p	CLIP-seq
MIRT1393680	hsa-miR-4803	CLIP-seq
MIRT1393681	hsa-miR-484	CLIP-seq
MIRT1393682	hsa-miR-515-5p	CLIP-seq
MIRT1393683	hsa-miR-548an	CLIP-seq
MIRT1393684	hsa-miR-573	CLIP-seq
MIRT1393685	hsa-miR-590-5p	CLIP-seq
MIRT1393686	hsa-miR-592	CLIP-seq
MIRT1393687	hsa-miR-597	CLIP-seq
MIRT1393688	hsa-miR-605	CLIP-seq
MIRT1393689	hsa-miR-634	CLIP-seq
MIRT1393690	hsa-miR-940	CLIP-seq
MIRT1557147	hsa-miR-3620	CLIP-seq
MIRT2340126	hsa-miR-1284	CLIP-seq
MIRT2340127	hsa-miR-2278	CLIP-seq
MIRT2340128	hsa-miR-2355-3p	CLIP-seq
MIRT2340129	hsa-miR-3120-3p	CLIP-seq
MIRT2340130	hsa-miR-337-3p	CLIP-seq
MIRT2340131	hsa-miR-3936	CLIP-seq
MIRT1393668	hsa-miR-3942-5p	CLIP-seq
MIRT2340132	hsa-miR-3976	CLIP-seq
MIRT2340133	hsa-miR-4503	CLIP-seq
MIRT2340134	hsa-miR-4690-3p	CLIP-seq
MIRT1393677	hsa-miR-4703-5p	CLIP-seq
MIRT2340135	hsa-miR-4765	CLIP-seq
MIRT2340136	hsa-miR-4771	CLIP-seq
MIRT2340137	hsa-miR-498	CLIP-seq
MIRT2340138	hsa-miR-499a-5p	CLIP-seq
MIRT2340139	hsa-miR-580	CLIP-seq
MIRT2340140	hsa-miR-662	CLIP-seq
MIRT2340141	hsa-miR-676	CLIP-seq
MIRT2340142	hsa-miR-758	CLIP-seq
MIRT2340143	hsa-miR-759	CLIP-seq
MIRT2395245	hsa-miR-1271	CLIP-seq
MIRT2395246	hsa-miR-182	CLIP-seq
MIRT2395247	hsa-miR-185	CLIP-seq
MIRT2395248	hsa-miR-342-5p	CLIP-seq
MIRT2395249	hsa-miR-3926	CLIP-seq
MIRT2395250	hsa-miR-4306	CLIP-seq
MIRT2395251	hsa-miR-4644	CLIP-seq
MIRT2395252	hsa-miR-4651	CLIP-seq
MIRT2395253	hsa-miR-4664-5p	CLIP-seq
MIRT2395254	hsa-miR-4729	CLIP-seq
MIRT2395255	hsa-miR-4786-5p	CLIP-seq
MIRT2395256	hsa-miR-548s	CLIP-seq
MIRT2395257	hsa-miR-579	CLIP-seq
MIRT2395258	hsa-miR-608	CLIP-seq
MIRT2395259	hsa-miR-664	CLIP-seq
MIRT2395260	hsa-miR-885-3p	CLIP-seq
MIRT2395261	hsa-miR-96	CLIP-seq
MIRT2460612	hsa-miR-3199	CLIP-seq
MIRT2460613	hsa-miR-4515	CLIP-seq
MIRT2460614	hsa-miR-4774-5p	CLIP-seq
MIRT1393652	hsa-miR-1252	CLIP-seq
MIRT2634053	hsa-miR-1915	CLIP-seq
MIRT2634054	hsa-miR-2116	CLIP-seq
MIRT2395248	hsa-miR-342-5p	CLIP-seq
MIRT1393666	hsa-miR-3714	CLIP-seq
MIRT1393671	hsa-miR-4476	CLIP-seq
MIRT1393672	hsa-miR-4484	CLIP-seq
MIRT1393673	hsa-miR-4496	CLIP-seq
MIRT2634055	hsa-miR-4505	CLIP-seq
MIRT1393674	hsa-miR-4509	CLIP-seq
MIRT1393675	hsa-miR-4533	CLIP-seq
MIRT2395252	hsa-miR-4651	CLIP-seq
MIRT2395253	hsa-miR-4664-5p	CLIP-seq
MIRT2634056	hsa-miR-4677-5p	CLIP-seq
MIRT2634057	hsa-miR-4726-3p	CLIP-seq
MIRT2634058	hsa-miR-4731-5p	CLIP-seq
MIRT1393683	hsa-miR-548an	CLIP-seq
MIRT2395258	hsa-miR-608	CLIP-seq
MIRT1393690	hsa-miR-940	CLIP-seq
MIRT1393652	hsa-miR-1252	CLIP-seq
MIRT2634053	hsa-miR-1915	CLIP-seq
MIRT2634054	hsa-miR-2116	CLIP-seq
MIRT2395248	hsa-miR-342-5p	CLIP-seq
MIRT1393666	hsa-miR-3714	CLIP-seq
MIRT1393671	hsa-miR-4476	CLIP-seq
MIRT1393672	hsa-miR-4484	CLIP-seq
MIRT1393673	hsa-miR-4496	CLIP-seq
MIRT2634055	hsa-miR-4505	CLIP-seq
MIRT1393674	hsa-miR-4509	CLIP-seq
MIRT1393675	hsa-miR-4533	CLIP-seq
MIRT2395252	hsa-miR-4651	CLIP-seq
MIRT2395253	hsa-miR-4664-5p	CLIP-seq
MIRT2634056	hsa-miR-4677-5p	CLIP-seq
MIRT2634057	hsa-miR-4726-3p	CLIP-seq
MIRT2634058	hsa-miR-4731-5p	CLIP-seq
MIRT1393683	hsa-miR-548an	CLIP-seq
MIRT2395258	hsa-miR-608	CLIP-seq
MIRT1393689	hsa-miR-634	CLIP-seq
MIRT1393690	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
POU2F1	Unknown	10814704
SP1	Unknown	10814704

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	20378551
GO:0000139	Component	Golgi membrane	TAS
GO:0003835	Function	Beta-galactoside alpha-2,6-sialyltransferase activity	IBA	21873635
GO:0003835	Function	Beta-galactoside alpha-2,6-sialyltransferase activity	IDA	23999306
GO:0003835	Function	Beta-galactoside alpha-2,6-sialyltransferase activity	TAS
GO:0005515	Function	Protein binding	IPI	16237761
GO:0005576	Component	Extracellular region	IEA
GO:0006054	Process	N-acetylneuraminate metabolic process	IDA	23999306
GO:0006959	Process	Humoral immune response	TAS	7786324
GO:0008373	Function	Sialyltransferase activity	IDA	21081508
GO:0016021	Component	Integral component of membrane	IEA
GO:0016266	Process	O-glycan processing	TAS
GO:0018279	Process	Protein N-linked glycosylation via asparagine	IDA	23999306
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	20378551
GO:0097503	Process	Sialylation	IDA	23999306

Other IDs

• MIM: 109675
• HGNC: 10860
• e!Ensembl: ENSG00000073849

Protein

• UniProt ID: P15907
• Protein name: Beta-galactoside alpha-2,6-sialyltransferase 1 (Alpha 2,6-ST 1) (EC 2.4.3.1) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1) (ST6Gal I) (ST6GalI) (Sialyltransferase 1)
• Protein function: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. In B lymphocytes, generates neuraminidase-sensitive lymphocyte cell-surface differentiation antigens, such as CDw75, HB-6 and CD76 (PubMed:1730763). {ECO:000
• PDB: 4JS1, 4JS2, 6QVS, 6QVT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00777	Glyco_transf_29	157 → 386	Glycosyltransferase family 29 (sialyltransferase)	Family

• Sequence:

  MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKEFQVLKSLGKLAMGSDS
  QSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSSKNLIPRLQKIWKNYLSMN
  KYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGP
  WGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTE
  KRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQM
  PWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFF
  DSACTMGAYHPLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC

• Sequence length: 406

Pathways

KEGG:

N-Glycan biosynthesis
Other types of O-glycan biosynthesis
Metabolic pathways

Reactome:

Sialic acid metabolism
N-Glycan antennae elongation
Termination of O-glycan biosynthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	28560309
Carcinoma	Squamous cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	22960999
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	16033404
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	30718926, 21874001, 23300278, 30054458, 30595370
Esophagus neoplasm	Esophageal Neoplasms	rs28934578, rs121918714, rs1567556006, rs1575166666	22960999
Glomerulonephritis	IGA Glomerulonephritis	rs778043831	26028593

Unknown
Disease name	Disease term	dbSNP ID	References
Impaired cognition	Impaired cognition		28560309