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BMI1 (BMI1 proto-oncogene, polycomb ring finger)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
648
Gene nameGene Name - the full gene name approved by the HGNC.
BMI1 proto-oncogene, polycomb ring finger
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
BMI1
SynonymsGene synonyms aliases
FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1
ChromosomeChromosome number
10
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p12.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000197 hsa-miR-200c-3p Review 20026422
MIRT004645 hsa-miR-128-3p Review 20029422
MIRT004645 hsa-miR-128-3p Immunohistochemistry, In situ hybridization, Microarray, qRT-PCR, Western blot 19010882
MIRT000197 hsa-miR-200c-3p Luciferase reporter assay, Western blot 19665978
MIRT000197 hsa-miR-200c-3p Luciferase reporter assay, Western blot 19665978
Transcription factors
Transcription factor Regulation Reference
E2F1 Unknown 17360938
MYC Activation 21856782
MYCN Activation 21856782
TWIST1 Activation 21876555
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 19636380
GO:0000151 Component Ubiquitin ligase complex IDA 16714294
GO:0005515 Function Protein binding IPI 15386022, 16710298, 17332741, 19233177, 19636380, 19903340, 20543829, 20601937, 21282530, 21772249, 22078878, 22493164, 22897849, 22902369, 23523425, 24981860, 25185265, 25416956, 26496610, 27705803, 28514442, 32296183
GO:0005634 Component Nucleus IDA 9367786, 10445843, 21282530
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Polycomb repressive complex
Signaling pathways regulating pluripotency of stem cells
Transcriptional misregulation in cancer
MicroRNAs in cancer
  Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Glioblastoma Glioblastoma, Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 19823589
Glioma Glioma, mixed gliomas, Malignant Glioma rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499, rs1060500122, rs781647403, rs1060500126, rs1554897889, rs1114167629, rs1114167656, rs587782603, rs1554893824, rs1554900615, rs1564568660, rs786204900, rs762518389, rs1339631701 23383216
Hirschsprung disease Hirschsprung Disease rs104893891, rs76262710, rs75075748, rs75996173, rs79014735, rs77316810, rs75076352, rs76087194, rs76534745, rs76764689, rs76449634, rs78098482, rs79661516, rs104894389, rs769735757, rs267606780, rs1568823467, rs377767412, rs193922699, rs75030001, rs606231342, rs1553540620, rs759944122, rs1057519322, rs1057519323, rs1057519052, rs1588873476, rs1588866040, rs1838178869 29429387
Myelodysplastic syndrome MYELODYSPLASTIC SYNDROME rs193303018, rs387906631, rs1576745225, rs373145711, rs752746786, rs377023736, rs373221034, rs1576749014, rs1600586587 24571310
Unknown
Disease name Disease term dbSNP ID References
Colonic aganglionosis Aganglionosis, Colonic, Aganglionosis, Rectosigmoid Colon 29429387
Congenital intestinal aganglionosis Congenital Intestinal Aganglionosis 29429387
Giant cell glioblastoma Giant Cell Glioblastoma 19823589
Myeloid leukemia Leukemia, Myeloid, Accelerated Phase 24571310

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