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ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains)
Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
64771
Gene nameGene Name - the full gene name approved by the HGNC.
Inflammation and lipid regulator with UBA-like and NBR1-like domains
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ILRUN
SynonymsGene synonyms aliases
C6orf106, FP852, dJ391O22.4
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.31
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT041868 hsa-miR-484 CLASH 23622248
MIRT042543 hsa-miR-423-3p CLASH 23622248
MIRT047483 hsa-miR-10b-5p CLASH 23622248
MIRT455499 hsa-miR-6510-5p PAR-CLIP 23592263
MIRT455500 hsa-miR-5739 PAR-CLIP 23592263
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0000407 Component Phagophore assembly site IBA 21873635
GO:0005515 Function Protein binding IPI 29802199
GO:0005634 Component Nucleus IDA 29802199
GO:0005737 Component Cytoplasm IDA 29802199
GO:0005813 Component Centrosome IDA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9H6K1
Protein name Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein)
Protein function Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199).
PDB 6VHI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14555 UBA_4
25 → 68
Domain
PF16158 N_BRCA1_IG
82 → 179
Ig-like domain from next to BRCA1 gene
 Domain
Sequence 
MEGMDVDLDPELMQKFSCLGTTDKDVLISEFQRLLGFQLNPAGCAFFLDMTNWNLQAAIG
AYYDFESPNISVPSMSFVEDVTIGEGESIPPDTQFVKTWRIQNSGAEAWPPGVCLKYVGG
DQFGHVNMVMVRSLEPQEIADVSVQMCSPSRAGMYQGQWRMCTATGLYYGDVIWVILSVE
VGGLLGVTQQLSSFETEFNTQPHRKVEGNFNPFASPQKNRQSDENNLKDPGGSEFDSISK
NTWAPAPDTWAPAPDQTEQDQNRLSQNSVNLSPSSHANNLSVVTYSKGLHGPYPFGQS
Sequence length 298
Interactions View interactions
Associated diseases
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Causal
Disease name Disease term dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537 29212778
Unknown
Disease name Disease term dbSNP ID References
Chagas cardiomyopathy Chagas Cardiomyopathy 24324551
Lymphocytic leukemia Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma 28165464
Lupus erythematosus Lupus Erythematosus, Systemic 23273568

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