SHMT1 (serine hydroxymethyltransferase 1)

Gene

• Entrez ID: 6470
• Gene name: Serine hydroxymethyltransferase 1
• Gene symbol: SHMT1
• Synonyms: CSHMT, SHMT
• Chromosome: 17
• Chromosome location: 17p11.2
• Summary: This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016266	hsa-miR-193b-3p	Microarray	20304954
MIRT045899	hsa-miR-125b-5p	CLASH	23622248
MIRT666395	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT666394	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT666393	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT666392	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT666391	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT505656	hsa-miR-4282	HITS-CLIP	23824327
MIRT666390	hsa-miR-548g-3p	HITS-CLIP	23824327
MIRT666389	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT666388	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT666387	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT666386	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT666385	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT666384	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT666382	hsa-miR-5696	HITS-CLIP	23824327
MIRT666383	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT666381	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT666380	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT666379	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT573047	hsa-miR-122-3p	PAR-CLIP	20371350
MIRT573045	hsa-miR-1234-3p	PAR-CLIP	20371350
MIRT573046	hsa-miR-7107-5p	PAR-CLIP	20371350
MIRT573044	hsa-miR-20b-3p	PAR-CLIP	20371350
MIRT573043	hsa-miR-4641	PAR-CLIP	20371350
MIRT573041	hsa-miR-4763-5p	PAR-CLIP	20371350
MIRT573042	hsa-miR-6735-3p	PAR-CLIP	20371350
MIRT505658	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT505657	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT505656	hsa-miR-4282	PAR-CLIP	21572407
MIRT505655	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT505654	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT554317	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT554316	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT505653	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT505652	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT505651	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT505650	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT505649	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT505648	hsa-miR-636	PAR-CLIP	21572407
MIRT554315	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT554314	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT505647	hsa-miR-4477a	PAR-CLIP	21572407
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	22012620
MIRT489667	hsa-miR-4302	PAR-CLIP	22012620
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	22012620
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	22012620
MIRT489664	hsa-miR-423-5p	PAR-CLIP	22012620
MIRT530206	hsa-miR-1914-3p	PAR-CLIP	22012620
MIRT530205	hsa-miR-5194	PAR-CLIP	22012620
MIRT530204	hsa-miR-6738-5p	PAR-CLIP	22012620
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	22012620
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	22012620
MIRT489660	hsa-miR-449a	PAR-CLIP	22012620
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	22012620
MIRT489658	hsa-miR-486-3p	PAR-CLIP	22012620
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	22012620
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	22012620
MIRT489654	hsa-let-7c-3p	PAR-CLIP	22012620
MIRT505658	hsa-miR-218-5p	PAR-CLIP	23446348
MIRT505657	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT505656	hsa-miR-4282	PAR-CLIP	23446348
MIRT505655	hsa-miR-224-3p	PAR-CLIP	23446348
MIRT505654	hsa-miR-522-3p	PAR-CLIP	23446348
MIRT505653	hsa-miR-508-3p	PAR-CLIP	23446348
MIRT505652	hsa-miR-219a-5p	PAR-CLIP	23446348
MIRT505651	hsa-miR-4782-3p	PAR-CLIP	23446348
MIRT505650	hsa-miR-6766-3p	PAR-CLIP	23446348
MIRT505649	hsa-miR-4445-5p	PAR-CLIP	23446348
MIRT505648	hsa-miR-636	PAR-CLIP	23446348
MIRT505647	hsa-miR-4477a	PAR-CLIP	23446348
MIRT489670	hsa-miR-4662a-3p	PAR-CLIP	23592263
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT489668	hsa-miR-3174	PAR-CLIP	23592263
MIRT489667	hsa-miR-4302	PAR-CLIP	23592263
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	23592263
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT489664	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT489660	hsa-miR-449a	PAR-CLIP	23592263
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT489658	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	23592263
MIRT489656	hsa-miR-921	PAR-CLIP	23592263
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT489654	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT489654	hsa-let-7c-3p	PAR-CLIP	27292025
MIRT489654	hsa-let-7c-3p	PAR-CLIP	27292025
MIRT530206	hsa-miR-1914-3p	PAR-CLIP	27292025
MIRT530206	hsa-miR-1914-3p	PAR-CLIP	27292025
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	27292025
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	27292025
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	27292025
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	27292025
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	27292025
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	27292025
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	27292025
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	27292025
MIRT489664	hsa-miR-423-5p	PAR-CLIP	27292025
MIRT489664	hsa-miR-423-5p	PAR-CLIP	27292025
MIRT489667	hsa-miR-4302	PAR-CLIP	27292025
MIRT489667	hsa-miR-4302	PAR-CLIP	27292025
MIRT489660	hsa-miR-449a	PAR-CLIP	27292025
MIRT489660	hsa-miR-449a	PAR-CLIP	27292025
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	27292025
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	27292025
MIRT489658	hsa-miR-486-3p	PAR-CLIP	27292025
MIRT489658	hsa-miR-486-3p	PAR-CLIP	27292025
MIRT530205	hsa-miR-5194	PAR-CLIP	27292025
MIRT530205	hsa-miR-5194	PAR-CLIP	27292025
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	27292025
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	27292025
MIRT530204	hsa-miR-6738-5p	PAR-CLIP	27292025
MIRT530204	hsa-miR-6738-5p	PAR-CLIP	27292025
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	27292025
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	27292025
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	27292025
MIRT735602	hsa-miR-6778-5p	Western blotting, Microarray, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR	32142918
MIRT666395	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT666394	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT666393	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT666392	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT666391	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT505656	hsa-miR-4282	HITS-CLIP	23824327
MIRT666390	hsa-miR-548g-3p	HITS-CLIP	23824327
MIRT666389	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT666388	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT666387	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT666386	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT666385	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT666384	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT666382	hsa-miR-5696	HITS-CLIP	23824327
MIRT666383	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT666381	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT666380	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT666379	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT573047	hsa-miR-122-3p	PAR-CLIP	20371350
MIRT573045	hsa-miR-1234-3p	PAR-CLIP	20371350
MIRT573046	hsa-miR-7107-5p	PAR-CLIP	20371350
MIRT573044	hsa-miR-20b-3p	PAR-CLIP	20371350
MIRT573043	hsa-miR-4641	PAR-CLIP	20371350
MIRT573041	hsa-miR-4763-5p	PAR-CLIP	20371350
MIRT573042	hsa-miR-6735-3p	PAR-CLIP	20371350
MIRT505658	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT505657	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT505656	hsa-miR-4282	PAR-CLIP	21572407
MIRT505655	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT505654	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT554317	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT554316	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT505653	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT505652	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT505651	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT505650	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT505649	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT505648	hsa-miR-636	PAR-CLIP	21572407
MIRT554315	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT554314	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT505647	hsa-miR-4477a	PAR-CLIP	21572407
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	22012620
MIRT489667	hsa-miR-4302	PAR-CLIP	22012620
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	22012620
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	22012620
MIRT489664	hsa-miR-423-5p	PAR-CLIP	22012620
MIRT530206	hsa-miR-1914-3p	PAR-CLIP	22012620
MIRT530205	hsa-miR-5194	PAR-CLIP	22012620
MIRT530204	hsa-miR-6738-5p	PAR-CLIP	22012620
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	22012620
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	22012620
MIRT489660	hsa-miR-449a	PAR-CLIP	22012620
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	22012620
MIRT489658	hsa-miR-486-3p	PAR-CLIP	22012620
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	22012620
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	22012620
MIRT489654	hsa-let-7c-3p	PAR-CLIP	22012620
MIRT505658	hsa-miR-218-5p	PAR-CLIP	23446348
MIRT505657	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT505656	hsa-miR-4282	PAR-CLIP	23446348
MIRT505655	hsa-miR-224-3p	PAR-CLIP	23446348
MIRT505654	hsa-miR-522-3p	PAR-CLIP	23446348
MIRT505653	hsa-miR-508-3p	PAR-CLIP	23446348
MIRT505652	hsa-miR-219a-5p	PAR-CLIP	23446348
MIRT505651	hsa-miR-4782-3p	PAR-CLIP	23446348
MIRT505650	hsa-miR-6766-3p	PAR-CLIP	23446348
MIRT505649	hsa-miR-4445-5p	PAR-CLIP	23446348
MIRT505648	hsa-miR-636	PAR-CLIP	23446348
MIRT505647	hsa-miR-4477a	PAR-CLIP	23446348
MIRT489670	hsa-miR-4662a-3p	PAR-CLIP	23592263
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT489668	hsa-miR-3174	PAR-CLIP	23592263
MIRT489667	hsa-miR-4302	PAR-CLIP	23592263
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	23592263
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT489664	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT489660	hsa-miR-449a	PAR-CLIP	23592263
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT489658	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	23592263
MIRT489656	hsa-miR-921	PAR-CLIP	23592263
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT489654	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT505658	hsa-miR-218-5p	Luciferase reporter assay, Western blotting	37799388
MIRT755614	hsa-miR-9-5p	Luciferase reporter assay, Western blotting	37799388
MIRT1347430	hsa-miR-3184	CLIP-seq
MIRT1347431	hsa-miR-34a	CLIP-seq
MIRT1347432	hsa-miR-449b	CLIP-seq
MIRT1347433	hsa-miR-298	CLIP-seq
MIRT1347434	hsa-miR-3120-3p	CLIP-seq
MIRT1347435	hsa-miR-3920	CLIP-seq
MIRT1347436	hsa-miR-4762-3p	CLIP-seq
MIRT1347437	hsa-miR-922	CLIP-seq
MIRT1347435	hsa-miR-3920	CLIP-seq
MIRT1347436	hsa-miR-4762-3p	CLIP-seq
MIRT2327215	hsa-miR-1266	CLIP-seq
MIRT2327216	hsa-miR-3127-3p	CLIP-seq
MIRT2327217	hsa-miR-3664-3p	CLIP-seq
MIRT2327218	hsa-miR-421	CLIP-seq
MIRT2327219	hsa-miR-4518	CLIP-seq
MIRT2327220	hsa-miR-4660	CLIP-seq
MIRT2327221	hsa-miR-4709-5p	CLIP-seq
MIRT2327222	hsa-miR-505	CLIP-seq
MIRT2327223	hsa-miR-646	CLIP-seq
MIRT2622462	hsa-miR-1243	CLIP-seq
MIRT2622463	hsa-miR-1261	CLIP-seq
MIRT2622464	hsa-miR-1271	CLIP-seq
MIRT2622465	hsa-miR-182	CLIP-seq
MIRT1347433	hsa-miR-298	CLIP-seq
MIRT1347434	hsa-miR-3120-3p	CLIP-seq
MIRT2622466	hsa-miR-3121-5p	CLIP-seq
MIRT2622467	hsa-miR-3138	CLIP-seq
MIRT2622468	hsa-miR-3185	CLIP-seq
MIRT2622469	hsa-miR-3611	CLIP-seq
MIRT2622470	hsa-miR-3622b-5p	CLIP-seq
MIRT1347435	hsa-miR-3920	CLIP-seq
MIRT2622471	hsa-miR-3945	CLIP-seq
MIRT2622472	hsa-miR-4252	CLIP-seq
MIRT2622473	hsa-miR-4253	CLIP-seq
MIRT2622474	hsa-miR-4277	CLIP-seq
MIRT2622475	hsa-miR-4279	CLIP-seq
MIRT2622476	hsa-miR-4642	CLIP-seq
MIRT2622477	hsa-miR-4760-3p	CLIP-seq
MIRT1347436	hsa-miR-4762-3p	CLIP-seq
MIRT2622478	hsa-miR-4800-5p	CLIP-seq
MIRT2622479	hsa-miR-4803	CLIP-seq
MIRT2622480	hsa-miR-570	CLIP-seq
MIRT2622481	hsa-miR-758	CLIP-seq
MIRT1347437	hsa-miR-922	CLIP-seq
MIRT2622482	hsa-miR-96	CLIP-seq
MIRT2622467	hsa-miR-3138	CLIP-seq
MIRT2622471	hsa-miR-3945	CLIP-seq
MIRT2622473	hsa-miR-4253	CLIP-seq
MIRT2622478	hsa-miR-4800-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MYC	Unknown	12138190

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000900	Function	Translation repressor activity, mRNA regulatory element binding	IBA	21873635
GO:0000900	Function	Translation repressor activity, mRNA regulatory element binding	IDA	10995219
GO:0004372	Function	Glycine hydroxymethyltransferase activity	IBA	21873635
GO:0004372	Function	Glycine hydroxymethyltransferase activity	IDA	8505317, 10995219, 17482557, 24698160
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	17482557
GO:0005829	Component	Cytosol	TAS
GO:0006544	Process	Glycine metabolic process	IDA	24698160
GO:0006563	Process	L-serine metabolic process	IDA	24698160
GO:0006565	Process	L-serine catabolic process	IBA	21873635
GO:0006565	Process	L-serine catabolic process	IDA	17482557
GO:0006730	Process	One-carbon metabolic process	IBA	21873635
GO:0008270	Function	Zinc ion binding	IBA	21873635
GO:0008732	Function	L-allo-threonine aldolase activity	IEA
GO:0009113	Process	Purine nucleobase biosynthetic process	IBA	21873635
GO:0009113	Process	Purine nucleobase biosynthetic process	IDA	11516159
GO:0017148	Process	Negative regulation of translation	IDA	10995219
GO:0019264	Process	Glycine biosynthetic process from serine	IBA	21873635
GO:0030170	Function	Pyridoxal phosphate binding	IBA	21873635
GO:0030170	Function	Pyridoxal phosphate binding	IDA	17482557, 24698160
GO:0035999	Process	Tetrahydrofolate interconversion	IBA	21873635
GO:0035999	Process	Tetrahydrofolate interconversion	IDA	24698160
GO:0035999	Process	Tetrahydrofolate interconversion	IEA
GO:0036094	Function	Small molecule binding	IPI	24698160
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0042803	Function	Protein homodimerization activity	IBA	21873635
GO:0042803	Function	Protein homodimerization activity	IDA	9753690
GO:0045329	Process	Carnitine biosynthetic process	TAS
GO:0046653	Process	Tetrahydrofolate metabolic process	IBA	21873635
GO:0046653	Process	Tetrahydrofolate metabolic process	IDA	24698160
GO:0046655	Process	Folic acid metabolic process	IBA	21873635
GO:0046655	Process	Folic acid metabolic process	IDA	11278996
GO:0046655	Process	Folic acid metabolic process	TAS
GO:0048027	Function	MRNA 5'-UTR binding	IBA	21873635
GO:0048027	Function	MRNA 5'-UTR binding	IDA	10995219
GO:0050897	Function	Cobalt ion binding	IBA	21873635
GO:0051289	Process	Protein homotetramerization	IBA	21873635
GO:0051289	Process	Protein homotetramerization	IDA	24698160
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070905	Function	Serine binding	IBA	21873635
GO:0070905	Function	Serine binding	IDA	24698160
GO:1904482	Process	Cellular response to tetrahydrofolate	IDA	24698160
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IBA	21873635

Other IDs

• MIM: 182144
• HGNC: 10850
• e!Ensembl: ENSG00000176974

Protein

• UniProt ID: P34896
• Protein name: Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)
• Protein function: Interconversion of serine and glycine (PubMed:24698160, PubMed:8505317).
• PDB: 1BJ4, 6FL5, 6M5W, 7RJL, 7RJP, 8A11, 8R7H
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00464	SHMT	26 → 425	Serine hydroxymethyltransferase	Domain

• Sequence:

  MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
  VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
  SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
  INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
  VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
  QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
  VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
  VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
  PDF

• Sequence length: 483

Pathways

KEGG:

Glycine, serine and threonine metabolism
Glyoxylate and dicarboxylate metabolism
One carbon pool by folate
Metabolic pathways
Carbon metabolism
Biosynthesis of amino acids
Biosynthesis of cofactors
Antifolate resistance
Folate transport and metabolism

Reactome:

Metabolism of folate and pterines
Carnitine synthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243	17595805
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	17595805
Diffuse lymphoma	Diffuse Mixed-Cell Lymphoma	rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291	17119116
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	27602772
Lymphoma	Lymphoma, Mixed-Cell, Lymphoma, Undifferentiated, Lymphoma, Small Noncleaved-Cell, Lymphoma, Diffuse, Lymphoma, Non-Hodgkin, Familial	rs11540652, rs1592119138, rs1592123162, rs1599367044	17119116
Non-hodgkin lymphoma	Lymphoma, Non-Hodgkin	rs121908689, rs28936699, rs121909775, rs398122800, rs121913357, rs121913355, rs398122820	17119116
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465, rs137854466, rs137854467, rs387906547, rs387906548, rs137854469, rs137854473, rs1131692050, rs112989722, rs137854474, rs137854476, rs140593, rs1555395819, rs137854478, rs137854479, rs137854480, rs137854481, rs137854482, rs137854483, rs137854484, rs137854485, rs112289537, rs193922181, rs193922182, rs193922185, rs140603, rs193922187, rs193922188, rs193921256, rs112660651, rs193922193, rs193922194, rs193922197, rs193922198, rs193922199, rs193922203, rs193922204, rs193922205, rs193922206, rs111401431, rs193922207, rs113871094, rs111671429, rs193922216, rs193922219, rs193922220, rs193922223, rs193922224, rs193922225, rs193922226, rs193922227, rs193922228, rs193922230, rs193922235, rs147195031, rs193922236, rs193922239, rs193922240, rs193922241, rs193922246, rs397514558, rs398122934, rs397515753, rs397515754, rs397515755, rs397515756, rs397515757, rs113812345, rs397515758, rs397515759, rs397515762, rs25403, rs397515765, rs397515766, rs397515767, rs397515768, rs397515769, rs397515770, rs397515771, rs25404, rs397515773, rs397515774, rs397515775, rs397515776, rs397515778, rs397515779, rs397515781, rs112202622, rs397515782, rs397515784, rs397515785, rs397515786, rs397515788, rs397515789, rs397515790, rs397515791, rs397515792, rs397515793, rs397515794, rs397515797, rs397515798, rs397515799, rs397515801, rs397515802, rs397515803, rs397515804, rs397515805, rs397515808, rs397515810, rs397515811, rs397515812, rs111231312, rs267606798, rs397515814, rs113905529, rs397515816, rs397515817, rs397515818, rs397515819, rs397515820, rs363853, rs113249837, rs397515821, rs111929350, rs397515823, rs397515824, rs113086760, rs397515825, rs397515826, rs397515827, rs363807, rs397515828, rs397515829, rs397515830, rs397515831, rs397515833, rs111687884, rs113080385, rs397515834, rs397515836, rs113001196, rs397515840, rs397515845, rs397515846, rs397515847, rs397515848, rs397515851, rs397515852, rs397515853, rs397515854, rs111856492, rs397515859, rs397515861, rs397515863, rs397515864, rs397515865, rs397515866, rs397515867, rs137854855, rs199474693, rs587782944, rs587782947, rs587782948, rs672601352, rs876658120, rs727504651, rs727503054, rs727504315, rs727504411, rs727503057, rs727504454, rs200309328, rs363811, rs727504410, rs363821, rs727504347, rs727505006, rs727505110, rs730880356, rs727505269, rs727503058, rs727504421, rs730880107, rs730880104, rs730880103, rs730880102, rs730880101, rs730880106, rs730880100, rs730880105, rs730880099, rs112645512, rs730880108, rs730880098, rs730880097, rs794728321, rs794728283, rs794728280, rs794728336, rs794728272, rs794728160, rs794728271, rs794728270, rs794728319, rs794728262, rs794728251, rs76702162, rs794728335, rs794728334, rs794728246, rs763091520, rs794728333, rs794728237, rs761857514, rs794728234, rs140630, rs794728231, rs794728228, rs794728225, rs794728308, rs794728216, rs794728221, rs763449629, rs201058219, rs794728210, rs794728208, rs794728206, rs794728199, rs794728195, rs794728194, rs794728193, rs794728190, rs1555399381, rs794728176, rs1555399968, rs113422242, rs794728326, rs794728166, rs794728325, rs794728165, rs794728162, rs794728213, rs869025417, rs112642323, rs869025416, rs869025415, rs869025424, rs869025423, rs869025414, rs869025422, rs869025413, rs869025412, rs869025411, rs869025418, rs869025426, rs869025406, rs869025421, rs869025425, rs869025404, rs869025420, rs869025403, rs398122833, rs876657645, rs878853686, rs878853676, rs886038919, rs886038795, rs187553035, rs886038869, rs886038949, rs886038967, rs886038976, rs886038848, rs886038940, rs886038877, rs886039038, rs886038817, rs886038963, rs886039036, rs886038797, rs886039550, rs886041482, rs1057517855, rs1057518912, rs1057518973, rs1057519502, rs1057521100, rs1057521102, rs1057518881, rs1057520617, rs1057521101, rs1555394445, rs369058466, rs1060501069, rs1060501031, rs778966916, rs1060501043, rs1555397663, rs1060501017, rs1060501094, rs1060501065, rs1555393848, rs1555394151, rs1060501051, rs1060501013, rs1060501054, rs1060501048, rs1060501089, rs1060501039, rs1555398160, rs1060501022, rs1060501024, rs1060501086, rs1060501058, rs1060501036, rs1060501100, rs1060501042, rs1060501059, rs1555397743, rs1060501021, rs1060501027, rs1060501096, rs1060501038, rs1060501050, rs1064794130, rs112118237, rs1064793980, rs1064793118, rs1064793636, rs1064794282, rs1064793559, rs1085307921, rs1085308004, rs1085307468, rs112907302, rs1131691479, rs1131691373, rs1131691467, rs1131691938, rs1131691311, rs1131691806, rs1131691317, rs1555393827, rs363804, rs1555397738, rs1555399144, rs1555400274, rs1555394195, rs1555398836, rs113543334, rs1555399825, rs1555394626, rs1555395256, rs1555395257, rs1555396427, rs1555397548, rs1555398173, rs1555404803, rs1232880706, rs1555393825, rs1555394567, rs1555396998, rs1555394928, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555399150, rs1555400373, rs1555405041, rs1555395229, rs1555397671, rs775417975, rs1555398774, rs1555399368, rs1555394904, rs1555395987, rs1555397424, rs1555398377, rs1555398835, rs1555401011, rs1555405043, rs1555394580, rs1555397404, rs1555398511, rs1555395826, rs1555399372, rs1555399821, rs1555399836, rs1555400063, rs363810, rs1555397655, rs1555395756, rs1555395742, rs1555393844, rs112550005, rs1555395002, rs1555395658, rs765387131, rs1555396429, rs1555396835, rs1555397014, rs1555397016, rs778710767, rs1555397557, rs1555397704, rs140648, rs1555398406, rs1555398681, rs1555399257, rs1555399361, rs1555399764, rs1555405056, rs1555393510, rs1555395980, rs1555396789, rs1555399094, rs1555399378, rs1555399816, rs1555395645, rs371097218, rs1555398278, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555405044, rs113544411, rs1555395663, rs1555397216, rs1555398989, rs1555399149, rs1555401670, rs1555395001, rs1445085747, rs1555393538, rs1555393565, rs1404133653, rs1555394450, rs1555394581, rs1555394633, rs1555394900, rs1555395189, rs1555395261, rs1052480459, rs1555395480, rs1555395670, rs363806, rs1555395820, rs1555396419, rs1555396765, rs1296209846, rs794728233, rs1555396853, rs1555396863, rs1555397197, rs1555397204, rs1555397212, rs1555397713, rs1555397736, rs1555398139, rs1555398144, rs1555398409, rs1555398510, rs1555398520, rs1555398524, rs1555398667, rs1555399089, rs1555399482, rs1555399763, rs1555401002, rs794728323, rs1555393508, rs1555393514, rs1555393525, rs1555393532, rs1555393653, rs1555393657, rs1555393824, rs1555393831, rs112196241, rs1555393847, rs1555393862, rs1555393863, rs1555393866, rs113935744, rs1555393882, rs1555393886, rs1555393889, rs1555394138, rs1555394144, rs1555394146, rs1555394148, rs1555394149, rs1555394152, rs1555394153, rs1555394189, rs1555394197, rs1555394206, rs1555394212, rs1555394218, rs1555394220, rs1555394235, rs1555394245, rs1555394246, rs1057520728, rs1555394390, rs1555394391, rs537570299, rs1555394397, rs1555394398, rs1555394399, rs1555394402, rs1555394407, rs1555394412, rs1555394435, rs1555394436, rs1555394441, rs1555394556, rs1555394557, rs1555394559, rs1555394561, rs1555394570, rs397515844, rs1555394571, rs1555394574, rs1555394579, rs1555394582, rs534811966, rs111588631, rs1555394628, rs1555394629, rs1555394630, rs1555394631, rs1555394641, rs1555394644, rs1555394647, rs1555394756, rs886051245, rs1555394775, rs1555394776, rs1555394777, rs1555394779, rs1555394780, rs1555394783, rs1555394901, rs1555394906, rs1555394925, rs794728253, rs886039158, rs1555395013, rs1555395187, rs1555395188, rs1555395203, rs1555395205, rs363815, rs1246984265, rs794728245, rs1555395263, rs1555395267, rs1555395456, rs1555395475, rs1555395482, rs1555395638, rs1555395641, rs1555395648, rs1555395653, rs1555395659, rs111239111, rs1555395745, rs1555395747, rs1555395753, rs1555395757, rs1555395766, rs1555395767, rs1555395843, rs1555395846, rs1555395849, rs1555395978, rs1555395981, rs1555395984, rs1555395989, rs1555395990, rs1260109901, rs1555396186, rs1555396188, rs1555396198, rs1555396199, rs1555396201, rs1555396202, rs1555396205, rs1555396213, rs1555396424, rs1555396426, rs1555396428, rs1555396435, rs1555396630, rs1555396635, rs1555396636, rs1555396639, rs1555396757, rs1555396769, rs1555396838, rs1555396844, rs140627, rs1555396858, rs1555396990, rs1555396991, rs1555396993, rs769588424, rs1555397022, rs1555397024, rs1555397160, rs1555397174, rs1555397176, rs1555397193, rs1555397209, rs1555397210, rs1555397214, rs1060501076, rs113082854, rs113693945, rs111978932, rs1555397403, rs1555397419, rs1555397420, rs1555397421, rs1555397536, rs1555397537, rs1555397540, rs1555397542, rs1555397543, rs1555397545, rs1555397546, rs1555397670, rs1555397692, rs1555397718, rs1555397723, rs1555397744, rs113393517, rs1555398148, rs1555398152, rs1555398174, rs1555398176, rs1555398179, rs1555398282, rs1555398287, rs1555398380, rs1555398394, rs1555398397, rs1555398401, rs1555398404, rs1555398407, rs1555398413, rs1555398501, rs1555398508, rs1555398512, rs1555398513, rs1555398515, rs1555398521, rs794728205, rs1555398527, rs1555398551, rs1060501075, rs1555398566, rs1555398572, rs1555398580, rs1555398582, rs140597, rs1555398622, rs1555398624, rs1555398625, rs112547596, rs1555398627, rs1555398633, rs1555398637, rs1555398642, rs778867355, rs1555398648, rs1555398659, rs1293095681, rs1060501040, rs987202268, rs1555398672, rs1555398673, rs1555398677, rs1555398793, rs1555398803, rs1555398811, rs1555398826, rs1555398833, rs1555398974, rs1555398981, rs778900586, rs1555398988, rs1555398994, rs1555398995, rs1555398996, rs1555399093, rs869025405, rs1555399101, rs1555399146, rs1555399160, rs1555399162, rs1555399164, rs1555399165, rs1555399193, rs1555399195, rs1555399202, rs1555399204, rs1555399206, rs201778577, rs1555399210, rs1555399214, rs1555399270, rs1555399273, rs1555399281, rs1555399371, rs1555399385, rs1555399477, rs1555399484, rs1555399761, rs1555399775, rs1555399802, rs1555399804, rs1555399837, rs1555399840, rs1555399940, rs1555399944, rs1555399949, rs1555399953, rs1555399954, rs1555399955, rs1555399959, rs1555399962, rs1555399963, rs1060501041, rs1555399974, rs1555399976, rs1555399977, rs1555400049, rs794728172, rs1555400062, rs1555400064, rs1555400066, rs1555400267, rs1555400268, rs1555400278, rs794728168, rs1555400279, rs1156747241, rs1555400288, rs1555400371, rs1555400372, rs1555400379, rs1555400385, rs587782943, rs1555400387, rs1555400406, rs1439533354, rs746201757, rs1555400595, rs1555400603, rs1555400604, rs1555400606, rs1555400609, rs752010116, rs1555400612, rs1555400616, rs1555401004, rs1555401005, rs146348130, rs1555401667, rs1555401671, rs1555401676, rs1555401679, rs1555401687, rs1555401689, rs1555401695, rs1555401697, rs1555401701, rs1555404799, rs1555404800, rs200295020, rs1555404810, rs1555404820, rs1555405031, rs1555405039, rs1555405045, rs1555405530, rs794728292, rs1555405533, rs1555405536, rs1555405537, rs111764111, rs1555405658, rs1555405664, rs774371494, rs1555405673, rs1555407399, rs1555407414, rs1555407423, rs1555407429, rs886041536, rs1555404806, rs1566911709, rs1566913974, rs1566894226, rs1566895223, rs1566897376, rs1566902526, rs1566915277, rs1566897374, rs1566897420, rs1566891655, rs1346043320, rs1566922396, rs1566891706, rs1566894783, rs1566913670, rs1555394196, rs1566891454, rs1566891406, rs1566891404, rs1566895262, rs1566891645, rs1566895225, rs1566896114, rs1566898399, rs1566904011, rs1566906537, rs1566908956, rs1566909766, rs1566919599, rs1566937712, rs1566915335, rs1566891675, rs1566904526, rs1566906506, rs1566900540, rs1566894230, rs1555395206, rs1566891797, rs1597512576, rs1597523873, rs1597581001, rs1597516325, rs1057524757, rs1597506641, rs1597520781, rs1597593695, rs1597529829, rs1597520625, rs1597579923, rs1597531796, rs1008275504, rs1597567249, rs1597569265, rs1597652471, rs1597516347, rs1597577114, rs1597633163, rs1597519658, rs1597593852, rs1597516501, rs1566913982, rs1555393859, rs1597513708, rs368978109, rs1480832655, rs1597520683, rs1597522390, rs1597522553, rs1597529748, rs1597533707, rs1597537815, rs1597545309, rs1597545836, rs1597563234, rs1597563280, rs1597564359, rs772108557, rs1597568968, rs1597574236, rs1597574308, rs1597577975, rs193922179, rs1597581005, rs1597593736, rs1597623670, rs1597625734, rs1597631662, rs113604459, rs1597633183, rs1597633219, rs1597518951, rs1555394781, rs1597525871, rs1597526073, rs1597569159, rs1597569536, rs1597563934, rs1597545199, rs1364210063, rs1597552583, rs1597520619, rs1597540854, rs1597591602, rs1597569551, rs1597548716, rs1597553721, rs112728248, rs1597537858, rs1597517935, rs1597540907, rs1597552388, rs1597591643, rs1597529841, rs1597506547, rs1597509836, rs1597529686, rs1566897404, rs1597533713, rs1597543486, rs1597545257, rs1597545345, rs1597548672, rs1597562812, rs1597563287, rs1597571391, rs1555400052, rs1597583989, rs363852, rs1597547226, rs363808, rs974604498, rs2043595650, rs2043526284, rs2042997306, rs1555397195, rs886039054, rs1555397213, rs2042873946	17595805
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20977478

Unknown
Disease name	Disease term	dbSNP ID	References
Mammary neoplasms	Mammary Neoplasms, Human, Mammary Neoplasms		17595805
High grade lymphoma	High Grade Lymphoma (neoplasm)		17119116
Intermediate grade lymphoma	Lymphoma, Intermediate-Grade		17119116
Low grade lymphoma	Low Grade Lymphoma (neoplasm)		17119116
Nervous system disorder	nervous system disorder		21064136
Reticulosarcoma	Reticulosarcoma		17119116