MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2)

Gene

• Entrez ID: 643246
• Gene name: Microtubule associated protein 1 light chain 3 beta 2
• Gene symbol: MAP1LC3B2
• Synonyms: ATG8G
• Chromosome: 12
• Chromosome location: 12q24.22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028572	hsa-miR-30a-5p	Proteomics	18668040
MIRT1127716	hsa-miR-1178	CLIP-seq
MIRT1127717	hsa-miR-124	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT1127721	hsa-miR-3614-5p	CLIP-seq
MIRT1127722	hsa-miR-3670	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT1127724	hsa-miR-3714	CLIP-seq
MIRT1127725	hsa-miR-3910	CLIP-seq
MIRT1127726	hsa-miR-432	CLIP-seq
MIRT1127727	hsa-miR-4328	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127730	hsa-miR-4633-3p	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127732	hsa-miR-4677-3p	CLIP-seq
MIRT1127733	hsa-miR-4679	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq
MIRT1127735	hsa-miR-506	CLIP-seq
MIRT1127736	hsa-miR-890	CLIP-seq
MIRT1127716	hsa-miR-1178	CLIP-seq
MIRT1551100	hsa-miR-320a	CLIP-seq
MIRT1551101	hsa-miR-320b	CLIP-seq
MIRT1551102	hsa-miR-320c	CLIP-seq
MIRT1551103	hsa-miR-320d	CLIP-seq
MIRT1551104	hsa-miR-4429	CLIP-seq
MIRT2036234	hsa-miR-1273e	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT2036235	hsa-miR-3545-3p	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT1127727	hsa-miR-4328	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127732	hsa-miR-4677-3p	CLIP-seq
MIRT1127733	hsa-miR-4679	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq
MIRT2036236	hsa-miR-494	CLIP-seq
MIRT2036237	hsa-miR-544	CLIP-seq
MIRT2036234	hsa-miR-1273e	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT2036235	hsa-miR-3545-3p	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT2266535	hsa-miR-369-5p	CLIP-seq
MIRT2266536	hsa-miR-4264	CLIP-seq
MIRT1127727	hsa-miR-4328	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127732	hsa-miR-4677-3p	CLIP-seq
MIRT1127733	hsa-miR-4679	CLIP-seq
MIRT2266537	hsa-miR-4695-3p	CLIP-seq
MIRT2266538	hsa-miR-4797-3p	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq
MIRT2036236	hsa-miR-494	CLIP-seq
MIRT2036237	hsa-miR-544	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT2036235	hsa-miR-3545-3p	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT2266535	hsa-miR-369-5p	CLIP-seq
MIRT2266536	hsa-miR-4264	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127732	hsa-miR-4677-3p	CLIP-seq
MIRT1127733	hsa-miR-4679	CLIP-seq
MIRT2266537	hsa-miR-4695-3p	CLIP-seq
MIRT2266538	hsa-miR-4797-3p	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127732	hsa-miR-4677-3p	CLIP-seq
MIRT1127733	hsa-miR-4679	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000045	Process	Autophagosome assembly	IBA	21873635
GO:0000421	Component	Autophagosome membrane	IBA	21873635
GO:0000422	Process	Autophagy of mitochondrion	IBA	21873635
GO:0005776	Component	Autophagosome	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005874	Component	Microtubule	IEA
GO:0006995	Process	Cellular response to nitrogen starvation	IBA	21873635
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0012505	Component	Endomembrane system	IEA
GO:0016236	Process	Macroautophagy	IBA	21873635
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0097352	Process	Autophagosome maturation	IBA	21873635

Other IDs

• MIM: 620673
• HGNC: 34390
• e!Ensembl: ENSG00000258102

Protein

• UniProt ID: A6NCE7
• Protein name: Microtubule-associated protein 1 light chain 3 beta 2 (Microtubule-associated proteins 1A/1B light chain 3 beta 2) (Microtubule-associated proteins 1A/1B light chain 3B-like) (MAP1A/MAP1B LC3 B-like) (MAP1A/MAP1B light chain 3 B-like)
• Protein function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cel
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02991	Atg8	15 → 120	Autophagy protein Atg8 ubiquitin like	Domain

• Sequence:

  MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
  SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVCASQETFG
  MKLSV

• Sequence length: 125

Pathways

KEGG:

Mitophagy - animal
Autophagy - animal
Ferroptosis
Apelin signaling pathway
NOD-like receptor signaling pathway
Amyotrophic lateral sclerosis
Pathways of neurodegeneration - multiple diseases
Shigellosis
Kaposi sarcoma-associated herpesvirus infection

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lymphoblastic leukemia	Precursor Cell Lymphoblastic Leukemia Lymphoma	rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591	19684603
Nasopharyngeal carcinoma	Nasopharyngeal carcinoma	rs200046052	20512145