ACOT1 (acyl-CoA thioesterase 1)

Gene

• Entrez ID: 641371
• Gene name: Acyl-CoA thioesterase 1
• Gene symbol: ACOT1
• Synonyms: ACH2, CTE-1, LACH2
• Chromosome: 14
• Chromosome location: 14q24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2166096	hsa-miR-185	CLIP-seq
MIRT2166097	hsa-miR-3180-5p	CLIP-seq
MIRT2166098	hsa-miR-4306	CLIP-seq
MIRT2166099	hsa-miR-4644	CLIP-seq
MIRT2166100	hsa-miR-4717-5p	CLIP-seq
MIRT2166101	hsa-miR-4766-3p	CLIP-seq
MIRT2166102	hsa-miR-4768-3p	CLIP-seq
MIRT2166103	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000038	Process	Very long-chain fatty acid metabolic process	IDA	16940157
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	16940157
GO:0005829	Component	Cytosol	IDA	16940157
GO:0005829	Component	Cytosol	TAS
GO:0006631	Process	Fatty acid metabolic process	IBA	21873635
GO:0006637	Process	Acyl-CoA metabolic process	IBA	21873635
GO:0006637	Process	Acyl-CoA metabolic process	IDA	16940157
GO:0006637	Process	Acyl-CoA metabolic process	TAS
GO:0016290	Function	Palmitoyl-CoA hydrolase activity	IEA
GO:0047617	Function	Acyl-CoA hydrolase activity	IBA	21873635
GO:0047617	Function	Acyl-CoA hydrolase activity	IDA	16940157
GO:0052689	Function	Carboxylic ester hydrolase activity	IEA
GO:0102991	Function	Myristoyl-CoA hydrolase activity	IEA

Other IDs

• MIM: 614313
• HGNC: 33128
• e!Ensembl: ENSG00000184227

Protein

• UniProt ID: Q86TX2
• Protein name: Acyl-coenzyme A thioesterase 1 (Acyl-CoA thioesterase 1) (EC 3.1.2.-) (CTE-I) (CTE-Ib) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (Palmitoyl-coenzyme A thioesterase)
• Protein function: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20). {ECO:0000269|PubMed:1694015
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04775	Bile_Hydr_Trans	16 → 141	Acyl-CoA thioester hydrolase/BAAT N-terminal region	Family
  PF08840	BAAT_C	203 → 412	BAAT / Acyl-CoA thioester hydrolase C terminal	Domain

• Sequence:

  MAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLGEL
  DLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDVRTPLAVELEVLDGHDPDPGRLL
  CRVRHERYFLPPGVRREPVRAGRVRGTLFLPPEPGPFPGIVDMFGTGGGLLEYRASLLAG
  KGFAVMALAYYNYEDLPKTMETLHLEYFEEAVNYLLSHPEVKGPGVGLLGISKGGELCLS
  MASFLKGITAAVVINGSVANVGGTLRYKGETLPPVGVNRNRIKVTKDGYADIVDVLNSPL
  EGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRRKPQIICYPETGH
  YIEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGGHEGTIPSK
  V

• Sequence length: 421

Pathways

KEGG:

Fatty acid elongation
Biosynthesis of unsaturated fatty acids
Metabolic pathways
Ovarian steroidogenesis

Reactome:

Mitochondrial Fatty Acid Beta-Oxidation

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver neoplasms	Liver neoplasms		25058030
Liver cancer	Malignant neoplasm of liver		25058030