SRR (serine racemase)

Gene

• Entrez ID: 63826
• Gene name: Serine racemase
• Gene symbol: SRR
• Synonyms: ILV1, ISO1
• Chromosome: 17
• Chromosome location: 17p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT731604	hsa-miR-193a-5p	Luciferase reporter assay	26913720
MIRT731604	hsa-miR-193a-5p	Luciferase reporter assay	26913720
MIRT731604	hsa-miR-193a-5p	Luciferase reporter assay	26913720
MIRT731604	hsa-miR-193a-5p	Luciferase reporter assay	26913720
MIRT731604	hsa-miR-193a-5p	Luciferase reporter assay	26913720
MIRT2116742	hsa-miR-3646	CLIP-seq
MIRT2339171	hsa-miR-561	CLIP-seq
MIRT2632951	hsa-miR-1207-5p	CLIP-seq
MIRT2632952	hsa-miR-1587	CLIP-seq
MIRT2632953	hsa-miR-2964a-5p	CLIP-seq
MIRT2632954	hsa-miR-3121-3p	CLIP-seq
MIRT2632955	hsa-miR-3155	CLIP-seq
MIRT2632956	hsa-miR-3155b	CLIP-seq
MIRT2632957	hsa-miR-3607-3p	CLIP-seq
MIRT2632958	hsa-miR-4265	CLIP-seq
MIRT2632959	hsa-miR-4273	CLIP-seq
MIRT2632960	hsa-miR-4282	CLIP-seq
MIRT2632961	hsa-miR-4296	CLIP-seq
MIRT2632962	hsa-miR-4322	CLIP-seq
MIRT2632963	hsa-miR-4330	CLIP-seq
MIRT2632964	hsa-miR-4417	CLIP-seq
MIRT2632965	hsa-miR-4436b-3p	CLIP-seq
MIRT2632966	hsa-miR-4502	CLIP-seq
MIRT2632967	hsa-miR-4674	CLIP-seq
MIRT2632968	hsa-miR-4677-5p	CLIP-seq
MIRT2632969	hsa-miR-4761-3p	CLIP-seq
MIRT2632970	hsa-miR-4762-3p	CLIP-seq
MIRT2632971	hsa-miR-4763-3p	CLIP-seq
MIRT2632972	hsa-miR-4775	CLIP-seq
MIRT2632973	hsa-miR-484	CLIP-seq
MIRT2632974	hsa-miR-511	CLIP-seq
MIRT2632975	hsa-miR-582-5p	CLIP-seq
MIRT2632976	hsa-miR-595	CLIP-seq
MIRT2632977	hsa-miR-600	CLIP-seq
MIRT2632978	hsa-miR-624	CLIP-seq
MIRT2632951	hsa-miR-1207-5p	CLIP-seq
MIRT2632952	hsa-miR-1587	CLIP-seq
MIRT2692015	hsa-miR-2355-3p	CLIP-seq
MIRT2632954	hsa-miR-3121-3p	CLIP-seq
MIRT2692016	hsa-miR-3140-3p	CLIP-seq
MIRT2632955	hsa-miR-3155	CLIP-seq
MIRT2632956	hsa-miR-3155b	CLIP-seq
MIRT2632957	hsa-miR-3607-3p	CLIP-seq
MIRT2632958	hsa-miR-4265	CLIP-seq
MIRT2632959	hsa-miR-4273	CLIP-seq
MIRT2632960	hsa-miR-4282	CLIP-seq
MIRT2632961	hsa-miR-4296	CLIP-seq
MIRT2632962	hsa-miR-4322	CLIP-seq
MIRT2632963	hsa-miR-4330	CLIP-seq
MIRT2632964	hsa-miR-4417	CLIP-seq
MIRT2632965	hsa-miR-4436b-3p	CLIP-seq
MIRT2692017	hsa-miR-4646-3p	CLIP-seq
MIRT2632967	hsa-miR-4674	CLIP-seq
MIRT2632968	hsa-miR-4677-5p	CLIP-seq
MIRT2632969	hsa-miR-4761-3p	CLIP-seq
MIRT2632971	hsa-miR-4763-3p	CLIP-seq
MIRT2632972	hsa-miR-4775	CLIP-seq
MIRT2632973	hsa-miR-484	CLIP-seq
MIRT2632975	hsa-miR-582-5p	CLIP-seq
MIRT2632976	hsa-miR-595	CLIP-seq
MIRT2632977	hsa-miR-600	CLIP-seq
MIRT2632978	hsa-miR-624	CLIP-seq
MIRT2692018	hsa-miR-676	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOS	Activation	15681805

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IBA	21873635
GO:0000287	Function	Magnesium ion binding	IDA	20106978
GO:0003941	Function	L-serine ammonia-lyase activity	IBA	21873635
GO:0003941	Function	L-serine ammonia-lyase activity	IDA	18812225
GO:0005509	Function	Calcium ion binding	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IBA	21873635
GO:0005524	Function	ATP binding	IDA	20106978
GO:0005524	Function	ATP binding	ISS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	16314870
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0006563	Process	L-serine metabolic process	IBA	21873635
GO:0006563	Process	L-serine metabolic process	IDA	11054547, 15193426, 20106978
GO:0006564	Process	L-serine biosynthetic process	TAS
GO:0007420	Process	Brain development	IEA
GO:0007568	Process	Aging	IEA
GO:0008721	Function	D-serine ammonia-lyase activity	IEA
GO:0009069	Process	Serine family amino acid metabolic process	ISS
GO:0016594	Function	Glycine binding	ISS
GO:0018114	Function	Threonine racemase activity	IBA	21873635
GO:0018114	Function	Threonine racemase activity	ISS
GO:0030165	Function	PDZ domain binding	IPI	16314870
GO:0030170	Function	Pyridoxal phosphate binding	IBA	21873635
GO:0030170	Function	Pyridoxal phosphate binding	IDA	20106978
GO:0030170	Function	Pyridoxal phosphate binding	ISS
GO:0030378	Function	Serine racemase activity	IBA	21873635
GO:0030378	Function	Serine racemase activity	IDA	11054547, 15193426, 20106978
GO:0032496	Process	Response to lipopolysaccharide	IEP	15681805
GO:0042493	Process	Response to drug	IEA
GO:0042802	Function	Identical protein binding	IPI	15681805, 32296183
GO:0042803	Function	Protein homodimerization activity	IPI	20106978
GO:0042866	Process	Pyruvate biosynthetic process	IBA	21873635
GO:0042866	Process	Pyruvate biosynthetic process	IDA	18812225
GO:0043025	Component	Neuronal cell body	IDA	17880399
GO:0043278	Process	Response to morphine	IEA
GO:0045177	Component	Apical part of cell	IEA
GO:0070178	Process	D-serine metabolic process	IDA	20106978
GO:0070179	Process	D-serine biosynthetic process	IBA	21873635
GO:0070179	Process	D-serine biosynthetic process	IDA	11054547, 15193426

Other IDs

• MIM: 606477
• HGNC: 14398
• e!Ensembl: ENSG00000167720

Protein

• UniProt ID: Q9GZT4
• Protein name: Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17)
• Protein function: Catalyzes the synthesis of D-serine from L-serine (PubMed:20106978, PubMed:23391306, PubMed:29277459). D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity). {EC
• PDB: 3L6B, 3L6R, 5X2L, 6SLH, 6ZSP, 6ZUJ, 7NBC, 7NBD, 7NBF, 7NBG, 7NBH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00291	PALP	19 → 314	Pyridoxal-phosphate dependent enzyme	Family

• Sequence:

  MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA
  LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA
  YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL
  VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV
  KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT
  VSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV

• Sequence length: 340

Pathways

KEGG:

Glycine, serine and threonine metabolism
D-Amino acid metabolism
Metabolic pathways

Reactome:

Serine biosynthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	21647700, 23300278, 20174558
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	27602772
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	23974872, 30285260, 15953485, 17067558, 22801410, 19483194, 28540026, 25056061, 31268507, 26198764

Unknown
Disease name	Disease term	dbSNP ID	References
Development disorder	Child Development Disorders, Pervasive		28540026