CXCL6 (C-X-C motif chemokine ligand 6)

Gene

• Entrez ID: 6372
• Gene name: C-X-C motif chemokine ligand 6
• Gene symbol: CXCL6
• Synonyms: CKA-3, GCP-2, GCP2, SCYB6
• Chromosome: 4
• Chromosome location: 4q13.3
• Summary: The protein encoded by this gene is a member CXC chemokine family. The encoded protein is a chemotactic for neutrophil granulocytes and has antibacterial action against gram-negative and gram-positive bacteria. This gene and other members of the CXC chemo

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029714	hsa-miR-26b-5p	Microarray	19088304
MIRT650703	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT650702	hsa-miR-4798-5p	HITS-CLIP	23824327
MIRT650703	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT650702	hsa-miR-4798-5p	HITS-CLIP	23824327
MIRT918109	hsa-miR-3148	CLIP-seq
MIRT918110	hsa-miR-3668	CLIP-seq
MIRT918111	hsa-miR-3688-3p	CLIP-seq
MIRT918112	hsa-miR-425	CLIP-seq
MIRT918113	hsa-miR-4694-3p	CLIP-seq
MIRT918114	hsa-miR-548aa	CLIP-seq
MIRT918115	hsa-miR-548ac	CLIP-seq
MIRT918116	hsa-miR-548d-3p	CLIP-seq
MIRT918117	hsa-miR-548n	CLIP-seq
MIRT918118	hsa-miR-548t	CLIP-seq
MIRT918119	hsa-miR-548z	CLIP-seq
MIRT918120	hsa-miR-642b	CLIP-seq
MIRT2207935	hsa-miR-1285	CLIP-seq
MIRT2207936	hsa-miR-3187-5p	CLIP-seq
MIRT2207937	hsa-miR-361-3p	CLIP-seq
MIRT2207938	hsa-miR-3973	CLIP-seq
MIRT2207939	hsa-miR-4463	CLIP-seq
MIRT2207940	hsa-miR-520g	CLIP-seq
MIRT2207941	hsa-miR-520h	CLIP-seq
MIRT2207942	hsa-miR-612	CLIP-seq
MIRT2436555	hsa-miR-101	CLIP-seq
MIRT2436556	hsa-miR-1276	CLIP-seq
MIRT2436557	hsa-miR-144	CLIP-seq
MIRT2436558	hsa-miR-199a-5p	CLIP-seq
MIRT2436559	hsa-miR-199b-5p	CLIP-seq
MIRT2436560	hsa-miR-3121-3p	CLIP-seq
MIRT2436561	hsa-miR-3130-5p	CLIP-seq
MIRT2436562	hsa-miR-329	CLIP-seq
MIRT2436563	hsa-miR-362-3p	CLIP-seq
MIRT2436564	hsa-miR-374c	CLIP-seq
MIRT2436565	hsa-miR-4255	CLIP-seq
MIRT2436566	hsa-miR-4311	CLIP-seq
MIRT2436567	hsa-miR-4482	CLIP-seq
MIRT2436568	hsa-miR-4803	CLIP-seq
MIRT2436569	hsa-miR-576-5p	CLIP-seq
MIRT2436570	hsa-miR-583	CLIP-seq
MIRT918120	hsa-miR-642b	CLIP-seq
MIRT2436571	hsa-miR-655	CLIP-seq
MIRT2436572	hsa-miR-802	CLIP-seq
MIRT2511404	hsa-miR-1	CLIP-seq
MIRT2436555	hsa-miR-101	CLIP-seq
MIRT2511405	hsa-miR-106a	CLIP-seq
MIRT2511406	hsa-miR-106b	CLIP-seq
MIRT2511407	hsa-miR-1253	CLIP-seq
MIRT2511408	hsa-miR-1257	CLIP-seq
MIRT2436556	hsa-miR-1276	CLIP-seq
MIRT2511409	hsa-miR-129-3p	CLIP-seq
MIRT2511410	hsa-miR-130a	CLIP-seq
MIRT2511411	hsa-miR-130b	CLIP-seq
MIRT2511412	hsa-miR-1323	CLIP-seq
MIRT2436557	hsa-miR-144	CLIP-seq
MIRT2511413	hsa-miR-17	CLIP-seq
MIRT2436558	hsa-miR-199a-5p	CLIP-seq
MIRT2436559	hsa-miR-199b-5p	CLIP-seq
MIRT2511414	hsa-miR-206	CLIP-seq
MIRT2511415	hsa-miR-20a	CLIP-seq
MIRT2511416	hsa-miR-20b	CLIP-seq
MIRT2511417	hsa-miR-2355-5p	CLIP-seq
MIRT2511418	hsa-miR-301a	CLIP-seq
MIRT2511419	hsa-miR-301b	CLIP-seq
MIRT2436560	hsa-miR-3121-3p	CLIP-seq
MIRT2511420	hsa-miR-3123	CLIP-seq
MIRT2511421	hsa-miR-3130-3p	CLIP-seq
MIRT2436561	hsa-miR-3130-5p	CLIP-seq
MIRT918109	hsa-miR-3148	CLIP-seq
MIRT2511422	hsa-miR-3174	CLIP-seq
MIRT2511423	hsa-miR-3200-5p	CLIP-seq
MIRT2436562	hsa-miR-329	CLIP-seq
MIRT2511424	hsa-miR-337-3p	CLIP-seq
MIRT2511425	hsa-miR-3606	CLIP-seq
MIRT2511426	hsa-miR-3617	CLIP-seq
MIRT2436563	hsa-miR-362-3p	CLIP-seq
MIRT2511427	hsa-miR-3647-3p	CLIP-seq
MIRT2511428	hsa-miR-3653	CLIP-seq
MIRT2511429	hsa-miR-3666	CLIP-seq
MIRT2511430	hsa-miR-3685	CLIP-seq
MIRT2511431	hsa-miR-3689a-5p	CLIP-seq
MIRT2511432	hsa-miR-3689b	CLIP-seq
MIRT2511433	hsa-miR-3689e	CLIP-seq
MIRT2511434	hsa-miR-3689f	CLIP-seq
MIRT2436564	hsa-miR-374c	CLIP-seq
MIRT2511435	hsa-miR-384	CLIP-seq
MIRT2511436	hsa-miR-3913-3p	CLIP-seq
MIRT2511437	hsa-miR-3938	CLIP-seq
MIRT2511438	hsa-miR-421	CLIP-seq
MIRT2436565	hsa-miR-4255	CLIP-seq
MIRT2511439	hsa-miR-4295	CLIP-seq
MIRT2436566	hsa-miR-4311	CLIP-seq
MIRT2511440	hsa-miR-4427	CLIP-seq
MIRT2511441	hsa-miR-4432	CLIP-seq
MIRT2511442	hsa-miR-4469	CLIP-seq
MIRT2511443	hsa-miR-4476	CLIP-seq
MIRT2511444	hsa-miR-4477b	CLIP-seq
MIRT2436567	hsa-miR-4482	CLIP-seq
MIRT2511445	hsa-miR-4511	CLIP-seq
MIRT2511446	hsa-miR-454	CLIP-seq
MIRT2511447	hsa-miR-4633-5p	CLIP-seq
MIRT2511448	hsa-miR-4666-5p	CLIP-seq
MIRT2511449	hsa-miR-4680-3p	CLIP-seq
MIRT2511450	hsa-miR-4687-5p	CLIP-seq
MIRT2511451	hsa-miR-4698	CLIP-seq
MIRT2511452	hsa-miR-4709-5p	CLIP-seq
MIRT2511453	hsa-miR-4712-3p	CLIP-seq
MIRT2511454	hsa-miR-4766-5p	CLIP-seq
MIRT2511455	hsa-miR-4778-5p	CLIP-seq
MIRT2511456	hsa-miR-4793-3p	CLIP-seq
MIRT2436568	hsa-miR-4803	CLIP-seq
MIRT2511457	hsa-miR-495	CLIP-seq
MIRT2511458	hsa-miR-499-5p	CLIP-seq
MIRT2511459	hsa-miR-513a-3p	CLIP-seq
MIRT2511460	hsa-miR-519a	CLIP-seq
MIRT2511461	hsa-miR-519b-3p	CLIP-seq
MIRT2511462	hsa-miR-519c-3p	CLIP-seq
MIRT2511463	hsa-miR-519d	CLIP-seq
MIRT2511464	hsa-miR-522	CLIP-seq
MIRT2511465	hsa-miR-544	CLIP-seq
MIRT918114	hsa-miR-548aa	CLIP-seq
MIRT2511466	hsa-miR-548b-3p	CLIP-seq
MIRT918117	hsa-miR-548n	CLIP-seq
MIRT2511467	hsa-miR-548o	CLIP-seq
MIRT918118	hsa-miR-548t	CLIP-seq
MIRT2511468	hsa-miR-568	CLIP-seq
MIRT2436569	hsa-miR-576-5p	CLIP-seq
MIRT2436570	hsa-miR-583	CLIP-seq
MIRT2511469	hsa-miR-587	CLIP-seq
MIRT2511470	hsa-miR-590-3p	CLIP-seq
MIRT2511471	hsa-miR-600	CLIP-seq
MIRT2511472	hsa-miR-613	CLIP-seq
MIRT2511473	hsa-miR-641	CLIP-seq
MIRT918120	hsa-miR-642b	CLIP-seq
MIRT2436571	hsa-miR-655	CLIP-seq
MIRT2511474	hsa-miR-656	CLIP-seq
MIRT2436572	hsa-miR-802	CLIP-seq
MIRT2511475	hsa-miR-875-5p	CLIP-seq
MIRT2511476	hsa-miR-889	CLIP-seq
MIRT2511477	hsa-miR-93	CLIP-seq
MIRT2511478	hsa-miR-938	CLIP-seq
MIRT2511404	hsa-miR-1	CLIP-seq
MIRT2436555	hsa-miR-101	CLIP-seq
MIRT2511405	hsa-miR-106a	CLIP-seq
MIRT2511406	hsa-miR-106b	CLIP-seq
MIRT2511407	hsa-miR-1253	CLIP-seq
MIRT2511408	hsa-miR-1257	CLIP-seq
MIRT2436556	hsa-miR-1276	CLIP-seq
MIRT2511409	hsa-miR-129-3p	CLIP-seq
MIRT2511410	hsa-miR-130a	CLIP-seq
MIRT2511411	hsa-miR-130b	CLIP-seq
MIRT2511412	hsa-miR-1323	CLIP-seq
MIRT2436557	hsa-miR-144	CLIP-seq
MIRT2511413	hsa-miR-17	CLIP-seq
MIRT2436558	hsa-miR-199a-5p	CLIP-seq
MIRT2436559	hsa-miR-199b-5p	CLIP-seq
MIRT2511414	hsa-miR-206	CLIP-seq
MIRT2511415	hsa-miR-20a	CLIP-seq
MIRT2511416	hsa-miR-20b	CLIP-seq
MIRT2511417	hsa-miR-2355-5p	CLIP-seq
MIRT2511418	hsa-miR-301a	CLIP-seq
MIRT2511419	hsa-miR-301b	CLIP-seq
MIRT2436560	hsa-miR-3121-3p	CLIP-seq
MIRT2511420	hsa-miR-3123	CLIP-seq
MIRT2511421	hsa-miR-3130-3p	CLIP-seq
MIRT2436561	hsa-miR-3130-5p	CLIP-seq
MIRT918109	hsa-miR-3148	CLIP-seq
MIRT2511422	hsa-miR-3174	CLIP-seq
MIRT2511423	hsa-miR-3200-5p	CLIP-seq
MIRT2436562	hsa-miR-329	CLIP-seq
MIRT2511424	hsa-miR-337-3p	CLIP-seq
MIRT2678873	hsa-miR-338-5p	CLIP-seq
MIRT2511425	hsa-miR-3606	CLIP-seq
MIRT2511426	hsa-miR-3617	CLIP-seq
MIRT2436563	hsa-miR-362-3p	CLIP-seq
MIRT2511427	hsa-miR-3647-3p	CLIP-seq
MIRT2511428	hsa-miR-3653	CLIP-seq
MIRT2511429	hsa-miR-3666	CLIP-seq
MIRT2511430	hsa-miR-3685	CLIP-seq
MIRT2511431	hsa-miR-3689a-5p	CLIP-seq
MIRT2511432	hsa-miR-3689b	CLIP-seq
MIRT2511433	hsa-miR-3689e	CLIP-seq
MIRT2511434	hsa-miR-3689f	CLIP-seq
MIRT2436564	hsa-miR-374c	CLIP-seq
MIRT2511435	hsa-miR-384	CLIP-seq
MIRT2511436	hsa-miR-3913-3p	CLIP-seq
MIRT2511437	hsa-miR-3938	CLIP-seq
MIRT2511438	hsa-miR-421	CLIP-seq
MIRT2436565	hsa-miR-4255	CLIP-seq
MIRT2511439	hsa-miR-4295	CLIP-seq
MIRT2436566	hsa-miR-4311	CLIP-seq
MIRT2511440	hsa-miR-4427	CLIP-seq
MIRT2511441	hsa-miR-4432	CLIP-seq
MIRT2511442	hsa-miR-4469	CLIP-seq
MIRT2511443	hsa-miR-4476	CLIP-seq
MIRT2511444	hsa-miR-4477b	CLIP-seq
MIRT2436567	hsa-miR-4482	CLIP-seq
MIRT2511445	hsa-miR-4511	CLIP-seq
MIRT2511446	hsa-miR-454	CLIP-seq
MIRT2511447	hsa-miR-4633-5p	CLIP-seq
MIRT2678874	hsa-miR-4666-3p	CLIP-seq
MIRT2511448	hsa-miR-4666-5p	CLIP-seq
MIRT2511449	hsa-miR-4680-3p	CLIP-seq
MIRT2511450	hsa-miR-4687-5p	CLIP-seq
MIRT2511451	hsa-miR-4698	CLIP-seq
MIRT2511452	hsa-miR-4709-5p	CLIP-seq
MIRT2511453	hsa-miR-4712-3p	CLIP-seq
MIRT2511454	hsa-miR-4766-5p	CLIP-seq
MIRT2511455	hsa-miR-4778-5p	CLIP-seq
MIRT2511456	hsa-miR-4793-3p	CLIP-seq
MIRT2436568	hsa-miR-4803	CLIP-seq
MIRT2511457	hsa-miR-495	CLIP-seq
MIRT2511458	hsa-miR-499-5p	CLIP-seq
MIRT2511459	hsa-miR-513a-3p	CLIP-seq
MIRT2511460	hsa-miR-519a	CLIP-seq
MIRT2511461	hsa-miR-519b-3p	CLIP-seq
MIRT2511462	hsa-miR-519c-3p	CLIP-seq
MIRT2511463	hsa-miR-519d	CLIP-seq
MIRT2511464	hsa-miR-522	CLIP-seq
MIRT2511465	hsa-miR-544	CLIP-seq
MIRT918114	hsa-miR-548aa	CLIP-seq
MIRT2511466	hsa-miR-548b-3p	CLIP-seq
MIRT918117	hsa-miR-548n	CLIP-seq
MIRT2511467	hsa-miR-548o	CLIP-seq
MIRT918118	hsa-miR-548t	CLIP-seq
MIRT2511468	hsa-miR-568	CLIP-seq
MIRT2436569	hsa-miR-576-5p	CLIP-seq
MIRT2436570	hsa-miR-583	CLIP-seq
MIRT2511469	hsa-miR-587	CLIP-seq
MIRT2511470	hsa-miR-590-3p	CLIP-seq
MIRT2511471	hsa-miR-600	CLIP-seq
MIRT2511472	hsa-miR-613	CLIP-seq
MIRT2511473	hsa-miR-641	CLIP-seq
MIRT918120	hsa-miR-642b	CLIP-seq
MIRT2436571	hsa-miR-655	CLIP-seq
MIRT2511474	hsa-miR-656	CLIP-seq
MIRT2436572	hsa-miR-802	CLIP-seq
MIRT2511475	hsa-miR-875-5p	CLIP-seq
MIRT2511476	hsa-miR-889	CLIP-seq
MIRT2511477	hsa-miR-93	CLIP-seq
MIRT2511478	hsa-miR-938	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001776	Process	Leukocyte homeostasis	IEA
GO:0005515	Function	Protein binding	IPI	28381538
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006935	Process	Chemotaxis	TAS	9164944
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0007165	Process	Signal transduction	TAS	9164944
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007267	Process	Cell-cell signaling	TAS	9164944
GO:0008009	Function	Chemokine activity	IBA	21873635
GO:0008009	Function	Chemokine activity	IDA	8399143
GO:0008201	Function	Heparin binding	IEA
GO:0030593	Process	Neutrophil chemotaxis	IBA	21873635
GO:0030593	Process	Neutrophil chemotaxis	IDA	8399143
GO:0032642	Process	Regulation of chemokine production	IEA
GO:0042119	Process	Neutrophil activation	IDA	8399143
GO:0042742	Process	Defense response to bacterium	IEA
GO:0045236	Function	CXCR chemokine receptor binding	IBA	21873635
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA	21873635
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	8399143
GO:0070098	Process	Chemokine-mediated signaling pathway	IBA	21873635
GO:0070951	Process	Regulation of neutrophil mediated killing of gram-negative bacterium	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA	21873635
GO:0071222	Process	Cellular response to lipopolysaccharide	IDA	8399143

Other IDs

• MIM: 138965
• HGNC: 10643
• e!Ensembl: ENSG00000124875

Protein

• UniProt ID: P80162
• Protein name: C-X-C motif chemokine 6 (Chemokine alpha 3) (CKA-3) (Granulocyte chemotactic protein 2) (GCP-2) (Small-inducible cytokine B6) [Cleaved into: Small-inducible cytokine B6, N-processed variant 1; Small-inducible cytokine B6, N-processed variant 2; Small-indu
• Protein function: Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-neg
• PDB: 8XWM, 8XXX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00048	IL8	47 → 106	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

• Sequence:

  MSLPSSRAARVPGPSGSLCALLALLLLLTPPGPLASAGPVSAVLTELRCTCLRVTLRVNP
  KTIGKLQVFPAGPQCSKVEVVASLKNGKQVCLDPEAPFLKKVIQKILDSGNKKN

• Sequence length: 114

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
IL-17 signaling pathway
TNF signaling pathway
Pertussis
Rheumatoid arthritis

Reactome:

Chemokine receptors bind chemokines
G alpha (i) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Arthritis	Degenerative polyarthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	15292528
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	15292528

Unknown
Disease name	Disease term	dbSNP ID	References
Osteoarthrosis deformans	Osteoarthrosis Deformans		15292528