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CCL22 (C-C motif chemokine ligand 22)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6367
Gene nameGene Name - the full gene name approved by the HGNC.
C-C motif chemokine ligand 22
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CCL22
SynonymsGene synonyms aliases
A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1
ChromosomeChromosome number
16
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q21
SummarySummary of gene provided in NCBI Entrez Gene.
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006869 hsa-miR-34a-5p Luciferase reporter assay 22975373
MIRT006869 hsa-miR-34a-5p Luciferase reporter assay 22975373
MIRT006869 hsa-miR-34a-5p Luciferase reporter assay 22975373
MIRT675850 hsa-miR-4798-3p HITS-CLIP 23824327
MIRT632179 hsa-miR-3929 HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
NFKB1 Activation 17018379
RELA Activation 17018379
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002548 Process Monocyte chemotaxis IBA 21873635
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
GO:0006935 Process Chemotaxis TAS 10861057
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O00626
Protein name C-C motif chemokine 22 (CC chemokine STCP-1) (MDC(1-69)) (Macrophage-derived chemokine) (Small-inducible cytokine A22) (Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC(3-69); MDC(5-69); MDC(7-69)]
Protein function May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for pr
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8
34 91
Small cytokines (intecrine/chemokine), interleukin-8 like
Domain
Sequence
Sequence length 93
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
C-type lectin receptor signaling pathway
  Chemokine receptors bind chemokines
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 22125604, 18249437
Unknown
Disease name Disease term dbSNP ID References
Eczema Eczema, Infantile 22125604, 18249437
Endometrioma Endometrioma 30579999
Endometriosis Endometriosis rs1800629, rs1143634 30579999

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