CCL14 (C-C motif chemokine ligand 14)

Gene

• Entrez ID: 6358
• Gene name: C-C motif chemokine ligand 14
• Gene symbol: CCL14
• Synonyms: CC-1, CC-3, CKB1, HCC-1, HCC-1(1-74), HCC-1/HCC-3, HCC-3, MCIF, NCC-2, NCC2, SCYA14, SCYL2, SY14
• Chromosome: 17
• Chromosome location: 17q12
• Summary: This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calciu

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017688	hsa-miR-335-5p	Microarray	18185580
MIRT023694	hsa-miR-1-3p	Microarray	18668037

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002548	Process	Monocyte chemotaxis	IBA	21873635
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006874	Process	Cellular calcium ion homeostasis	TAS	8551235
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0008009	Function	Chemokine activity	IBA	21873635
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	8551235
GO:0030593	Process	Neutrophil chemotaxis	IBA	21873635
GO:0043547	Process	Positive regulation of GTPase activity	IBA	21873635
GO:0048020	Function	CCR chemokine receptor binding	IBA	21873635
GO:0048247	Process	Lymphocyte chemotaxis	IBA	21873635
GO:0070098	Process	Chemokine-mediated signaling pathway	IBA	21873635
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IBA	21873635
GO:0071346	Process	Cellular response to interferon-gamma	IBA	21873635
GO:0071347	Process	Cellular response to interleukin-1	IBA	21873635
GO:0071356	Process	Cellular response to tumor necrosis factor	IBA	21873635

Other IDs

• MIM: 601392
• HGNC: 10612
• e!Ensembl: ENSG00000276409

Protein

• UniProt ID: Q16627
• Protein name: C-C motif chemokine 14 (Chemokine CC-1/CC-3) (HCC-1/HCC-3) (HCC-1(1-74)) (NCC-2) (Small-inducible cytokine A14) [Cleaved into: HCC-1(3-74); HCC-1(4-74); HCC-1(9-74)]
• Protein function: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, ne
• PDB: 2Q8R, 2Q8T
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00048	IL8	33 → 90	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

• Sequence:

  MKISVAAIPFFLLITIALGTKTESSSRGPYHPSECCFTYTTYKIPRQRIMDYYETNSQCS
  KPGIVFITKRGHSVCTNPSDKWVQDYIKDMKEN

• Sequence length: 93

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560