CCL8 (C-C motif chemokine ligand 8)

Gene

• Entrez ID: 6355
• Gene name: C-C motif chemokine ligand 8
• Gene symbol: CCL8
• Synonyms: HC14, MCP-2, MCP2, SCYA10, SCYA8
• Chromosome: 17
• Chromosome location: 17q12
• Summary: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050431	hsa-miR-23a-3p	CLASH	23622248
MIRT438289	hsa-miR-92a-3p	Luciferase reporter assay, Western blot, qRT-PCR	25253336
MIRT438289	hsa-miR-92a-3p	Luciferase reporter assay, Western blot, qRT-PCR	25253336
MIRT871120	hsa-miR-1226	CLIP-seq
MIRT871121	hsa-miR-1290	CLIP-seq
MIRT871122	hsa-miR-181a	CLIP-seq
MIRT871123	hsa-miR-181b	CLIP-seq
MIRT871124	hsa-miR-181c	CLIP-seq
MIRT871125	hsa-miR-181d	CLIP-seq
MIRT871126	hsa-miR-33a	CLIP-seq
MIRT871127	hsa-miR-33b	CLIP-seq
MIRT871128	hsa-miR-4262	CLIP-seq
MIRT871129	hsa-miR-450b-5p	CLIP-seq
MIRT871130	hsa-miR-4733-3p	CLIP-seq
MIRT871131	hsa-miR-499-3p	CLIP-seq
MIRT871132	hsa-miR-499a-3p	CLIP-seq
MIRT871133	hsa-miR-507	CLIP-seq
MIRT871134	hsa-miR-557	CLIP-seq
MIRT1958661	hsa-miR-1305	CLIP-seq
MIRT1958662	hsa-miR-203	CLIP-seq
MIRT1958663	hsa-miR-4698	CLIP-seq
MIRT1958664	hsa-miR-607	CLIP-seq
MIRT871120	hsa-miR-1226	CLIP-seq
MIRT2498686	hsa-miR-1324	CLIP-seq
MIRT2498687	hsa-miR-186	CLIP-seq
MIRT2498688	hsa-miR-1910	CLIP-seq
MIRT2498689	hsa-miR-216a	CLIP-seq
MIRT2498690	hsa-miR-216b	CLIP-seq
MIRT2498691	hsa-miR-3065-5p	CLIP-seq
MIRT2498692	hsa-miR-3613-3p	CLIP-seq
MIRT2498693	hsa-miR-3653	CLIP-seq
MIRT2498694	hsa-miR-3658	CLIP-seq
MIRT2498695	hsa-miR-3670	CLIP-seq
MIRT2498696	hsa-miR-3682-3p	CLIP-seq
MIRT2498697	hsa-miR-3689a-3p	CLIP-seq
MIRT2498698	hsa-miR-3689c	CLIP-seq
MIRT2498699	hsa-miR-3691-5p	CLIP-seq
MIRT2498700	hsa-miR-4264	CLIP-seq
MIRT2498701	hsa-miR-4266	CLIP-seq
MIRT2498702	hsa-miR-4419a	CLIP-seq
MIRT2498703	hsa-miR-4424	CLIP-seq
MIRT2498704	hsa-miR-4493	CLIP-seq
MIRT2498705	hsa-miR-4510	CLIP-seq
MIRT2498706	hsa-miR-4522	CLIP-seq
MIRT2498707	hsa-miR-455-3p	CLIP-seq
MIRT2498708	hsa-miR-4695-5p	CLIP-seq
MIRT2498709	hsa-miR-4700-3p	CLIP-seq
MIRT2498710	hsa-miR-4716-5p	CLIP-seq
MIRT2498711	hsa-miR-4728-5p	CLIP-seq
MIRT871130	hsa-miR-4733-3p	CLIP-seq
MIRT2498712	hsa-miR-4751	CLIP-seq
MIRT2498713	hsa-miR-4752	CLIP-seq
MIRT2498714	hsa-miR-4753-3p	CLIP-seq
MIRT2498715	hsa-miR-4764-5p	CLIP-seq
MIRT2498716	hsa-miR-4779	CLIP-seq
MIRT2498717	hsa-miR-4797-3p	CLIP-seq
MIRT871131	hsa-miR-499-3p	CLIP-seq
MIRT871132	hsa-miR-499a-3p	CLIP-seq
MIRT2498718	hsa-miR-5095	CLIP-seq
MIRT2498719	hsa-miR-5096	CLIP-seq
MIRT2498720	hsa-miR-513a-5p	CLIP-seq
MIRT2498721	hsa-miR-520g	CLIP-seq
MIRT2498722	hsa-miR-520h	CLIP-seq
MIRT2498723	hsa-miR-548c-3p	CLIP-seq
MIRT2498724	hsa-miR-570	CLIP-seq
MIRT2498725	hsa-miR-640	CLIP-seq
MIRT2498726	hsa-miR-656	CLIP-seq
MIRT2498727	hsa-miR-944	CLIP-seq
MIRT871120	hsa-miR-1226	CLIP-seq
MIRT871121	hsa-miR-1290	CLIP-seq
MIRT2498686	hsa-miR-1324	CLIP-seq
MIRT2498687	hsa-miR-186	CLIP-seq
MIRT2498688	hsa-miR-1910	CLIP-seq
MIRT2498689	hsa-miR-216a	CLIP-seq
MIRT2498690	hsa-miR-216b	CLIP-seq
MIRT2498691	hsa-miR-3065-5p	CLIP-seq
MIRT2498692	hsa-miR-3613-3p	CLIP-seq
MIRT2498693	hsa-miR-3653	CLIP-seq
MIRT2498694	hsa-miR-3658	CLIP-seq
MIRT2498695	hsa-miR-3670	CLIP-seq
MIRT2498696	hsa-miR-3682-3p	CLIP-seq
MIRT2498697	hsa-miR-3689a-3p	CLIP-seq
MIRT2498698	hsa-miR-3689c	CLIP-seq
MIRT2498699	hsa-miR-3691-5p	CLIP-seq
MIRT2498700	hsa-miR-4264	CLIP-seq
MIRT2498701	hsa-miR-4266	CLIP-seq
MIRT2498702	hsa-miR-4419a	CLIP-seq
MIRT2498703	hsa-miR-4424	CLIP-seq
MIRT2498704	hsa-miR-4493	CLIP-seq
MIRT871129	hsa-miR-450b-5p	CLIP-seq
MIRT2498705	hsa-miR-4510	CLIP-seq
MIRT2498706	hsa-miR-4522	CLIP-seq
MIRT2498707	hsa-miR-455-3p	CLIP-seq
MIRT2498708	hsa-miR-4695-5p	CLIP-seq
MIRT2498709	hsa-miR-4700-3p	CLIP-seq
MIRT2498710	hsa-miR-4716-5p	CLIP-seq
MIRT2498711	hsa-miR-4728-5p	CLIP-seq
MIRT871130	hsa-miR-4733-3p	CLIP-seq
MIRT2498712	hsa-miR-4751	CLIP-seq
MIRT2498713	hsa-miR-4752	CLIP-seq
MIRT2498714	hsa-miR-4753-3p	CLIP-seq
MIRT2498715	hsa-miR-4764-5p	CLIP-seq
MIRT2498716	hsa-miR-4779	CLIP-seq
MIRT2498717	hsa-miR-4797-3p	CLIP-seq
MIRT871131	hsa-miR-499-3p	CLIP-seq
MIRT871132	hsa-miR-499a-3p	CLIP-seq
MIRT871133	hsa-miR-507	CLIP-seq
MIRT2498718	hsa-miR-5095	CLIP-seq
MIRT2498719	hsa-miR-5096	CLIP-seq
MIRT2498720	hsa-miR-513a-5p	CLIP-seq
MIRT2498721	hsa-miR-520g	CLIP-seq
MIRT2498722	hsa-miR-520h	CLIP-seq
MIRT2498723	hsa-miR-548c-3p	CLIP-seq
MIRT871134	hsa-miR-557	CLIP-seq
MIRT2498724	hsa-miR-570	CLIP-seq
MIRT2498725	hsa-miR-640	CLIP-seq
MIRT2498726	hsa-miR-656	CLIP-seq
MIRT2498727	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002548	Process	Monocyte chemotaxis	IBA	21873635
GO:0002687	Process	Positive regulation of leukocyte migration	IEA
GO:0004672	Function	Protein kinase activity	IDA	10734056
GO:0005515	Function	Protein binding	IPI	28381538
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IEA
GO:0006816	Process	Calcium ion transport	IDA	10734056
GO:0006874	Process	Cellular calcium ion homeostasis	IDA	10734056
GO:0006887	Process	Exocytosis	IDA	10734056
GO:0006935	Process	Chemotaxis	TAS	9468473
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0007165	Process	Signal transduction	TAS	9119400
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007267	Process	Cell-cell signaling	IDA	10734056
GO:0008009	Function	Chemokine activity	IBA	21873635
GO:0008201	Function	Heparin binding	IEA
GO:0009615	Process	Response to virus	TAS	9468473
GO:0016004	Function	Phospholipase activator activity	IDA	10734056
GO:0030593	Process	Neutrophil chemotaxis	IBA	21873635
GO:0043547	Process	Positive regulation of GTPase activity	IBA	21873635
GO:0044828	Process	Negative regulation by host of viral genome replication	IDA	20181935
GO:0048020	Function	CCR chemokine receptor binding	IBA	21873635
GO:0048245	Process	Eosinophil chemotaxis	IBA	21873635
GO:0048247	Process	Lymphocyte chemotaxis	IBA	21873635
GO:0070098	Process	Chemokine-mediated signaling pathway	IBA	21873635
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IBA	21873635
GO:0070664	Process	Negative regulation of leukocyte proliferation	IEA
GO:0071346	Process	Cellular response to interferon-gamma	IBA	21873635
GO:0071347	Process	Cellular response to interleukin-1	IBA	21873635
GO:0071356	Process	Cellular response to tumor necrosis factor	IBA	21873635

Other IDs

• MIM: 602283
• HGNC: 10635
• e!Ensembl: ENSG00000108700

Protein

• UniProt ID: P80075
• Protein name: C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)]
• Protein function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic ac
• PDB: 1ESR, 7S59, 7S5A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00048	IL8	32 → 90	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

• Sequence:

  MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCP
  KEAVIFKTKRGKEVCADPKERWVRDSMKHLDQIFQNLKP

• Sequence length: 99

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	17568789

Unknown
Disease name	Disease term	dbSNP ID	References
Nephrogenic fibrosing dermopathy	Nephrogenic Fibrosing Dermopathy		20959327