CCL7 (C-C motif chemokine ligand 7)

Gene

• Entrez ID: 6354
• Gene name: C-C motif chemokine ligand 7
• Gene symbol: CCL7
• Synonyms: FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7
• Chromosome: 17
• Chromosome location: 17q12
• Summary: This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029409	hsa-miR-26b-5p	Microarray	19088304
MIRT054392	hsa-let-7f-5p	Luciferase reporter assay	22894925
MIRT1958657	hsa-miR-300	CLIP-seq
MIRT1958658	hsa-miR-381	CLIP-seq
MIRT1958659	hsa-miR-4666-3p	CLIP-seq
MIRT1958660	hsa-miR-4789-5p	CLIP-seq
MIRT2436134	hsa-miR-188-3p	CLIP-seq
MIRT2436135	hsa-miR-324-5p	CLIP-seq
MIRT2436136	hsa-miR-4328	CLIP-seq
MIRT2436137	hsa-miR-765	CLIP-seq
MIRT2436134	hsa-miR-188-3p	CLIP-seq
MIRT2436135	hsa-miR-324-5p	CLIP-seq
MIRT2436136	hsa-miR-4328	CLIP-seq
MIRT2436137	hsa-miR-765	CLIP-seq
MIRT2446479	hsa-let-7a	CLIP-seq
MIRT2446480	hsa-let-7b	CLIP-seq
MIRT2446481	hsa-let-7c	CLIP-seq
MIRT2446482	hsa-let-7d	CLIP-seq
MIRT2446483	hsa-let-7e	CLIP-seq
MIRT2446484	hsa-let-7f	CLIP-seq
MIRT2446485	hsa-let-7g	CLIP-seq
MIRT2446486	hsa-let-7i	CLIP-seq
MIRT2446487	hsa-miR-1321	CLIP-seq
MIRT2446488	hsa-miR-202	CLIP-seq
MIRT2446489	hsa-miR-3123	CLIP-seq
MIRT2446490	hsa-miR-3154	CLIP-seq
MIRT2446491	hsa-miR-3925-5p	CLIP-seq
MIRT2446492	hsa-miR-3927	CLIP-seq
MIRT2446493	hsa-miR-4451	CLIP-seq
MIRT2446494	hsa-miR-4458	CLIP-seq
MIRT2446495	hsa-miR-4500	CLIP-seq
MIRT2446496	hsa-miR-4739	CLIP-seq
MIRT2446497	hsa-miR-4756-5p	CLIP-seq
MIRT2436137	hsa-miR-765	CLIP-seq
MIRT2446498	hsa-miR-98	CLIP-seq
MIRT2446479	hsa-let-7a	CLIP-seq
MIRT2446480	hsa-let-7b	CLIP-seq
MIRT2446481	hsa-let-7c	CLIP-seq
MIRT2446482	hsa-let-7d	CLIP-seq
MIRT2446483	hsa-let-7e	CLIP-seq
MIRT2446484	hsa-let-7f	CLIP-seq
MIRT2446485	hsa-let-7g	CLIP-seq
MIRT2446486	hsa-let-7i	CLIP-seq
MIRT2498670	hsa-miR-1273f	CLIP-seq
MIRT2446487	hsa-miR-1321	CLIP-seq
MIRT2498671	hsa-miR-1323	CLIP-seq
MIRT2498672	hsa-miR-143	CLIP-seq
MIRT2436134	hsa-miR-188-3p	CLIP-seq
MIRT2446488	hsa-miR-202	CLIP-seq
MIRT1958657	hsa-miR-300	CLIP-seq
MIRT2498673	hsa-miR-3120-3p	CLIP-seq
MIRT2446489	hsa-miR-3123	CLIP-seq
MIRT2446490	hsa-miR-3154	CLIP-seq
MIRT2436135	hsa-miR-324-5p	CLIP-seq
MIRT2498674	hsa-miR-338-5p	CLIP-seq
MIRT1958658	hsa-miR-381	CLIP-seq
MIRT2446491	hsa-miR-3925-5p	CLIP-seq
MIRT2446492	hsa-miR-3927	CLIP-seq
MIRT2436136	hsa-miR-4328	CLIP-seq
MIRT2446493	hsa-miR-4451	CLIP-seq
MIRT2446494	hsa-miR-4458	CLIP-seq
MIRT2446495	hsa-miR-4500	CLIP-seq
MIRT2498675	hsa-miR-4640-3p	CLIP-seq
MIRT1958659	hsa-miR-4666-3p	CLIP-seq
MIRT2498676	hsa-miR-4668-3p	CLIP-seq
MIRT2498677	hsa-miR-4699-5p	CLIP-seq
MIRT2498678	hsa-miR-4708-5p	CLIP-seq
MIRT2446496	hsa-miR-4739	CLIP-seq
MIRT2446497	hsa-miR-4756-5p	CLIP-seq
MIRT2498679	hsa-miR-4770	CLIP-seq
MIRT1958660	hsa-miR-4789-5p	CLIP-seq
MIRT2498680	hsa-miR-548aa	CLIP-seq
MIRT2498681	hsa-miR-548ac	CLIP-seq
MIRT2498682	hsa-miR-548d-3p	CLIP-seq
MIRT2498683	hsa-miR-548o	CLIP-seq
MIRT2498684	hsa-miR-548z	CLIP-seq
MIRT2498685	hsa-miR-7	CLIP-seq
MIRT2436137	hsa-miR-765	CLIP-seq
MIRT2446498	hsa-miR-98	CLIP-seq
MIRT2446479	hsa-let-7a	CLIP-seq
MIRT2446480	hsa-let-7b	CLIP-seq
MIRT2446481	hsa-let-7c	CLIP-seq
MIRT2446482	hsa-let-7d	CLIP-seq
MIRT2446483	hsa-let-7e	CLIP-seq
MIRT2446484	hsa-let-7f	CLIP-seq
MIRT2446485	hsa-let-7g	CLIP-seq
MIRT2446486	hsa-let-7i	CLIP-seq
MIRT2498670	hsa-miR-1273f	CLIP-seq
MIRT2446487	hsa-miR-1321	CLIP-seq
MIRT2498671	hsa-miR-1323	CLIP-seq
MIRT2498672	hsa-miR-143	CLIP-seq
MIRT2436134	hsa-miR-188-3p	CLIP-seq
MIRT2446488	hsa-miR-202	CLIP-seq
MIRT1958657	hsa-miR-300	CLIP-seq
MIRT2498673	hsa-miR-3120-3p	CLIP-seq
MIRT2446489	hsa-miR-3123	CLIP-seq
MIRT2446490	hsa-miR-3154	CLIP-seq
MIRT2436135	hsa-miR-324-5p	CLIP-seq
MIRT2498674	hsa-miR-338-5p	CLIP-seq
MIRT1958658	hsa-miR-381	CLIP-seq
MIRT2446491	hsa-miR-3925-5p	CLIP-seq
MIRT2446492	hsa-miR-3927	CLIP-seq
MIRT2436136	hsa-miR-4328	CLIP-seq
MIRT2446493	hsa-miR-4451	CLIP-seq
MIRT2446494	hsa-miR-4458	CLIP-seq
MIRT2446495	hsa-miR-4500	CLIP-seq
MIRT2498675	hsa-miR-4640-3p	CLIP-seq
MIRT1958659	hsa-miR-4666-3p	CLIP-seq
MIRT2498676	hsa-miR-4668-3p	CLIP-seq
MIRT2498677	hsa-miR-4699-5p	CLIP-seq
MIRT2498678	hsa-miR-4708-5p	CLIP-seq
MIRT2446496	hsa-miR-4739	CLIP-seq
MIRT2446497	hsa-miR-4756-5p	CLIP-seq
MIRT2498679	hsa-miR-4770	CLIP-seq
MIRT1958660	hsa-miR-4789-5p	CLIP-seq
MIRT2498683	hsa-miR-548o	CLIP-seq
MIRT2498685	hsa-miR-7	CLIP-seq
MIRT2436137	hsa-miR-765	CLIP-seq
MIRT2446498	hsa-miR-98	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
LEF1	Unknown	11118053

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002548	Process	Monocyte chemotaxis	IBA	21873635
GO:0002548	Process	Monocyte chemotaxis	IC	10660125
GO:0005515	Function	Protein binding	IPI	25416956, 26095031, 32296183
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006874	Process	Cellular calcium ion homeostasis	TAS	10770925
GO:0006935	Process	Chemotaxis	TAS	9780207
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0007010	Process	Cytoskeleton organization	IDA	10072545
GO:0007165	Process	Signal transduction	TAS	10201901, 10770925
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007267	Process	Cell-cell signaling	TAS	7916328
GO:0008009	Function	Chemokine activity	IBA	21873635
GO:0008009	Function	Chemokine activity	IDA	10072545
GO:0008201	Function	Heparin binding	IEA
GO:0008360	Process	Regulation of cell shape	IDA	10072545
GO:0010332	Process	Response to gamma radiation	IEA
GO:0030335	Process	Positive regulation of cell migration	IDA	7545673
GO:0030593	Process	Neutrophil chemotaxis	IBA	21873635
GO:0031726	Function	CCR1 chemokine receptor binding	IPI	7545673, 10660125
GO:0031727	Function	CCR2 chemokine receptor binding	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IBA	21873635
GO:0048020	Function	CCR chemokine receptor binding	IBA	21873635
GO:0048245	Process	Eosinophil chemotaxis	IBA	21873635
GO:0048245	Process	Eosinophil chemotaxis	IDA	10072545
GO:0048247	Process	Lymphocyte chemotaxis	IBA	21873635
GO:0070098	Process	Chemokine-mediated signaling pathway	IBA	21873635
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IBA	21873635
GO:0071346	Process	Cellular response to interferon-gamma	IBA	21873635
GO:0071347	Process	Cellular response to interleukin-1	IBA	21873635
GO:0071356	Process	Cellular response to tumor necrosis factor	IBA	21873635
GO:0071361	Process	Cellular response to ethanol	IEA
GO:2000503	Process	Positive regulation of natural killer cell chemotaxis	IDA	7545673

Other IDs

• MIM: 158106
• HGNC: 10634
• e!Ensembl: ENSG00000108688

Protein

• UniProt ID: P80098
• Protein name: C-C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (NC28) (Small-inducible cytokine A7)
• Protein function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
• PDB: 1BO0, 1NCV, 4ZKC, 7S58, 7S59, 7SCU, 8FJ3, 8FK6, 8FK8, 8JPS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00048	IL8	32 → 90	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

• Sequence:

  MKASAALLCLLLTAAAFSPQGLAQPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCP
  REAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPKL

• Sequence length: 99

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
IL-17 signaling pathway

Reactome:

Chemokine receptors bind chemokines

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Cholestasis	Cholestasis	rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039	21224055
Glomerulonephritis	Glomerulonephritis	rs778043831	10385480

Unknown
Disease name	Disease term	dbSNP ID	References
Cerebral infraction	Infarction, Middle Cerebral Artery		12374626
Bright disease	Bright Disease		10385480
Cerebral thrombosis	Middle Cerebral Artery Thrombosis		12374626
Malignant mesothelioma	Malignant mesothelioma		25162674
Nephritis	Nephritis, Interstitial, Nephritis, Tubulointerstitial		10385480