CCL4 (C-C motif chemokine ligand 4)

Gene

• Entrez ID: 6351
• Gene name: C-C motif chemokine ligand 4
• Gene symbol: CCL4
• Synonyms: ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4
• Chromosome: 17
• Chromosome location: 17q12
• Summary: The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004669	hsa-miR-195-5p	ELISA, Immunoprecipitaion, qRT-PCR, Western blot	20952681

Transcription factors

Transcription factor	Regulation	Reference
CREM	Repression	16443828
NFKB1	Unknown	11342414
RELA	Unknown	11342414

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002548	Process	Monocyte chemotaxis	IBA	21873635
GO:0005125	Function	Cytokine activity	TAS	2462251
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0006955	Process	Immune response	TAS	10929056
GO:0007155	Process	Cell adhesion	TAS	10929056
GO:0007163	Process	Establishment or maintenance of cell polarity	TAS	9759849
GO:0007165	Process	Signal transduction	TAS	9558100, 10929056
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007267	Process	Cell-cell signaling	TAS	2521882
GO:0008009	Function	Chemokine activity	IBA	21873635
GO:0009615	Process	Response to virus	TAS	9743377
GO:0009636	Process	Response to toxic substance	IDA	10841574
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0030593	Process	Neutrophil chemotaxis	IBA	21873635
GO:0031726	Function	CCR1 chemokine receptor binding	IPI	7545673
GO:0031730	Function	CCR5 chemokine receptor binding	IPI	10383387, 10679098
GO:0042802	Function	Identical protein binding	IPI	20959807
GO:0043547	Process	Positive regulation of GTPase activity	IBA	21873635
GO:0043922	Process	Negative regulation by host of viral transcription	IDA	10841574
GO:0048020	Function	CCR chemokine receptor binding	IBA	21873635
GO:0048245	Process	Eosinophil chemotaxis	IBA	21873635
GO:0048247	Process	Lymphocyte chemotaxis	IBA	21873635
GO:0050850	Process	Positive regulation of calcium-mediated signaling	IMP	10679098
GO:0051928	Process	Positive regulation of calcium ion transport	IDA	8699119
GO:0070098	Process	Chemokine-mediated signaling pathway	IBA	21873635
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IBA	21873635
GO:0071346	Process	Cellular response to interferon-gamma	IBA	21873635
GO:0071347	Process	Cellular response to interleukin-1	IBA	21873635
GO:0071356	Process	Cellular response to tumor necrosis factor	IBA	21873635
GO:2000503	Process	Positive regulation of natural killer cell chemotaxis	IDA	7545673

Other IDs

• MIM: 182284
• HGNC: 10630
• e!Ensembl: ENSG00000275302

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
NF-kappa B signaling pathway
Toll-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Human cytomegalovirus infection

Reactome:

Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Glomerulonephritis	Glomerulonephritis	rs778043831	10385480
Pulmonary fibrosis	Pulmonary Fibrosis	rs121918666, rs199422300, rs121917737, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs863223336, rs786205702, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899, rs938938578	17720292

Unknown
Disease name	Disease term	dbSNP ID	References
Alveolitis	Alveolitis, Fibrosing		17720292
Arsenic encephalopathy	Arsenic Encephalopathy		16835338
Atherosclerosis	Atherosclerosis	rs699947, rs59439148	24370436
Bright disease	Bright Disease		10385480
Cerebral ischemia	Brain Ischemia		15829914
Dermatologic disorders	Dermatologic disorders		16835338
Myocardial ischemia	Myocardial Ischemia		16214533