SAT1 (spermidine/spermine N1-acetyltransferase 1)

Gene

• Entrez ID: 6303
• Gene name: Spermidine/spermine N1-acetyltransferase 1
• Gene symbol: SAT1
• Synonyms: DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1
• Chromosome: X
• Chromosome location: Xp22.11
• Summary: The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the int

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019180	hsa-miR-335-5p	Microarray	18185580
MIRT026968	hsa-miR-107	Microarray	20489155
MIRT048548	hsa-miR-100-5p	CLASH	23622248
MIRT039551	hsa-miR-652-3p	CLASH	23622248
MIRT037883	hsa-miR-455-3p	CLASH	23622248
MIRT037497	hsa-miR-744-5p	CLASH	23622248
MIRT504006	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT504005	hsa-miR-551b-5p	PAR-CLIP	21572407
MIRT504004	hsa-miR-1244	PAR-CLIP	21572407
MIRT504003	hsa-miR-4477a	PAR-CLIP	21572407
MIRT504006	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT504005	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT504004	hsa-miR-1244	PAR-CLIP	23446348
MIRT504003	hsa-miR-4477a	PAR-CLIP	23446348
MIRT504006	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT504005	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT504004	hsa-miR-1244	PAR-CLIP	23446348
MIRT504003	hsa-miR-4477a	PAR-CLIP	23446348
MIRT504006	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT504005	hsa-miR-551b-5p	PAR-CLIP	21572407
MIRT504004	hsa-miR-1244	PAR-CLIP	21572407
MIRT504003	hsa-miR-4477a	PAR-CLIP	21572407
MIRT504006	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT504005	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT504004	hsa-miR-1244	PAR-CLIP	23446348
MIRT504003	hsa-miR-4477a	PAR-CLIP	23446348
MIRT504006	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT504005	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT504004	hsa-miR-1244	PAR-CLIP	23446348
MIRT504003	hsa-miR-4477a	PAR-CLIP	23446348
MIRT1326586	hsa-miR-1283	CLIP-seq
MIRT1326587	hsa-miR-186	CLIP-seq
MIRT1326588	hsa-miR-199a-5p	CLIP-seq
MIRT1326589	hsa-miR-199b-5p	CLIP-seq
MIRT1326590	hsa-miR-3177-5p	CLIP-seq
MIRT1326591	hsa-miR-3907	CLIP-seq
MIRT1326592	hsa-miR-4259	CLIP-seq
MIRT1326593	hsa-miR-4302	CLIP-seq
MIRT1326594	hsa-miR-4506	CLIP-seq
MIRT1326595	hsa-miR-451b	CLIP-seq
MIRT1326596	hsa-miR-4795-3p	CLIP-seq
MIRT1326597	hsa-miR-618	CLIP-seq
MIRT1326586	hsa-miR-1283	CLIP-seq
MIRT2321277	hsa-miR-4252	CLIP-seq
MIRT1326592	hsa-miR-4259	CLIP-seq
MIRT2321278	hsa-miR-4425	CLIP-seq
MIRT1326595	hsa-miR-451b	CLIP-seq
MIRT1326596	hsa-miR-4795-3p	CLIP-seq
MIRT2321279	hsa-miR-607	CLIP-seq
MIRT2321277	hsa-miR-4252	CLIP-seq
MIRT2321279	hsa-miR-607	CLIP-seq
MIRT2617526	hsa-miR-1	CLIP-seq
MIRT1326586	hsa-miR-1283	CLIP-seq
MIRT2617527	hsa-miR-139-5p	CLIP-seq
MIRT1326588	hsa-miR-199a-5p	CLIP-seq
MIRT1326589	hsa-miR-199b-5p	CLIP-seq
MIRT2617528	hsa-miR-206	CLIP-seq
MIRT2617529	hsa-miR-217	CLIP-seq
MIRT2617530	hsa-miR-3064-3p	CLIP-seq
MIRT2617531	hsa-miR-3121-3p	CLIP-seq
MIRT2617532	hsa-miR-3156-5p	CLIP-seq
MIRT1326590	hsa-miR-3177-5p	CLIP-seq
MIRT2617533	hsa-miR-3200-5p	CLIP-seq
MIRT2617534	hsa-miR-320a	CLIP-seq
MIRT2617535	hsa-miR-320b	CLIP-seq
MIRT2617536	hsa-miR-320c	CLIP-seq
MIRT2617537	hsa-miR-320d	CLIP-seq
MIRT2617538	hsa-miR-323b-5p	CLIP-seq
MIRT2617539	hsa-miR-3673	CLIP-seq
MIRT2617540	hsa-miR-3689d	CLIP-seq
MIRT1326591	hsa-miR-3907	CLIP-seq
MIRT2617541	hsa-miR-4251	CLIP-seq
MIRT2321277	hsa-miR-4252	CLIP-seq
MIRT1326592	hsa-miR-4259	CLIP-seq
MIRT2617542	hsa-miR-4272	CLIP-seq
MIRT1326593	hsa-miR-4302	CLIP-seq
MIRT2617543	hsa-miR-4329	CLIP-seq
MIRT2321278	hsa-miR-4425	CLIP-seq
MIRT2617544	hsa-miR-4428	CLIP-seq
MIRT2617545	hsa-miR-4429	CLIP-seq
MIRT2617546	hsa-miR-4490	CLIP-seq
MIRT1326594	hsa-miR-4506	CLIP-seq
MIRT1326595	hsa-miR-451b	CLIP-seq
MIRT2617547	hsa-miR-4522	CLIP-seq
MIRT2617548	hsa-miR-4715-3p	CLIP-seq
MIRT1326596	hsa-miR-4795-3p	CLIP-seq
MIRT2617549	hsa-miR-4799-5p	CLIP-seq
MIRT2617550	hsa-miR-4802-5p	CLIP-seq
MIRT2617551	hsa-miR-515-5p	CLIP-seq
MIRT2321279	hsa-miR-607	CLIP-seq
MIRT2617552	hsa-miR-613	CLIP-seq
MIRT1326597	hsa-miR-618	CLIP-seq
MIRT2617526	hsa-miR-1	CLIP-seq
MIRT1326586	hsa-miR-1283	CLIP-seq
MIRT2617527	hsa-miR-139-5p	CLIP-seq
MIRT2617528	hsa-miR-206	CLIP-seq
MIRT2617529	hsa-miR-217	CLIP-seq
MIRT2617530	hsa-miR-3064-3p	CLIP-seq
MIRT2617531	hsa-miR-3121-3p	CLIP-seq
MIRT2617533	hsa-miR-3200-5p	CLIP-seq
MIRT2617534	hsa-miR-320a	CLIP-seq
MIRT2617535	hsa-miR-320b	CLIP-seq
MIRT2617536	hsa-miR-320c	CLIP-seq
MIRT2617537	hsa-miR-320d	CLIP-seq
MIRT2617538	hsa-miR-323b-5p	CLIP-seq
MIRT2617539	hsa-miR-3673	CLIP-seq
MIRT2617540	hsa-miR-3689d	CLIP-seq
MIRT1326591	hsa-miR-3907	CLIP-seq
MIRT2617541	hsa-miR-4251	CLIP-seq
MIRT2321277	hsa-miR-4252	CLIP-seq
MIRT1326592	hsa-miR-4259	CLIP-seq
MIRT2617543	hsa-miR-4329	CLIP-seq
MIRT2321278	hsa-miR-4425	CLIP-seq
MIRT2617545	hsa-miR-4429	CLIP-seq
MIRT2617546	hsa-miR-4490	CLIP-seq
MIRT1326594	hsa-miR-4506	CLIP-seq
MIRT1326595	hsa-miR-451b	CLIP-seq
MIRT2617547	hsa-miR-4522	CLIP-seq
MIRT2617548	hsa-miR-4715-3p	CLIP-seq
MIRT1326596	hsa-miR-4795-3p	CLIP-seq
MIRT2617549	hsa-miR-4799-5p	CLIP-seq
MIRT2617550	hsa-miR-4802-5p	CLIP-seq
MIRT2617551	hsa-miR-515-5p	CLIP-seq
MIRT2321279	hsa-miR-607	CLIP-seq
MIRT2617552	hsa-miR-613	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
PPARD	Activation	14506281
PPARG	Activation	14506281
PPARG	Unknown	14750214

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEP	11866539
GO:0004145	Function	Diamine N-acetyltransferase activity	IBA	21873635
GO:0004145	Function	Diamine N-acetyltransferase activity	IDA	15283699
GO:0004145	Function	Diamine N-acetyltransferase activity	TAS
GO:0005515	Function	Protein binding	IPI	16169070, 16189514, 19060904, 21516116, 25416956, 29892012, 31515488, 32296183, 32814053
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006596	Process	Polyamine biosynthetic process	IDA	15283699
GO:0006596	Process	Polyamine biosynthetic process	TAS
GO:0008080	Function	N-acetyltransferase activity	IBA	21873635
GO:0008080	Function	N-acetyltransferase activity	IDA	15283699
GO:0009447	Process	Putrescine catabolic process	IEA
GO:0019809	Function	Spermidine binding	IBA	21873635
GO:0032918	Process	Spermidine acetylation	IBA	21873635
GO:0032918	Process	Spermidine acetylation	IDA	15283699
GO:0042802	Function	Identical protein binding	IPI	16189514, 16455797, 25416956

Other IDs

• MIM: 313020
• HGNC: 10540
• e!Ensembl: ENSG00000130066

Protein

• UniProt ID: P21673
• Protein name: Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1)
• Protein function: Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632). Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine (PubMed:17516632). This highly regulated enzyme allows
• PDB: 2B3U, 2B3V, 2B4B, 2B4D, 2B58, 2B5G, 2F5I, 2FXF, 2G3T, 2JEV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00583	Acetyltransf_1	14 → 145	Acetyltransferase (GNAT) family	Family

• Sequence:

  MAKFVIRPATAADCSDILRLIKELAKYEYMEEQVILTEKDLLEDGFGEHPFYHCLVAEVP
  KEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYRGFGIGSEILKNLSQVAMRC
  RCSSMHFLVAEWNEPSINFYKRRGASDLSSEEGWRLFKIDKEYLLKMATEE

• Sequence length: 171

Pathways

KEGG:

Arginine and proline metabolism
Metabolic pathways
Ferroptosis

Reactome:

Interconversion of polyamines

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	17374397
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	20882379

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		23958961, 23768751
Keratosis follicularis spinulosa decalvans	Keratosis pilaris decalvans, Keratosis follicularis spinulosa decalvans		12215835
Mental depression	Depressive disorder, Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	19152344, 19851986, 19152344
Mood disorder	Mood Disorders		21152090
Nonorganic psychosis	Nonorganic psychosis		23958961
Psychosis	Psychotic Disorders		23958961
Schizoaffective disorder	Schizoaffective Disorder		23958961