RTN1 (reticulon 1)

Gene

• Entrez ID: 6252
• Gene name: Reticulon 1
• Gene symbol: RTN1
• Synonyms: NSP
• Chromosome: 14
• Chromosome location: 14q23.1
• Summary: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specifi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1321937	hsa-miR-147	CLIP-seq
MIRT1321938	hsa-miR-3140-3p	CLIP-seq
MIRT737878	hsa-miR-4711-5p	CLIP-seq
MIRT737878	hsa-miR-4711-5p	CLIP-seq
MIRT737878	hsa-miR-4711-5p	CLIP-seq
MIRT737878	hsa-miR-4711-5p	CLIP-seq
MIRT737878	hsa-miR-4711-5p	CLIP-seq
MIRT737878	hsa-miR-4711-5p	CLIP-seq
MIRT737878	hsa-miR-4711-5p	CLIP-seq
MIRT737878	hsa-miR-4711-5p	CLIP-seq
MIRT737878	hsa-miR-4711-5p	CLIP-seq
MIRT737878	hsa-miR-4711-5p	CLIP-seq
MIRT2458688	hsa-miR-138	CLIP-seq
MIRT2458689	hsa-miR-142-5p	CLIP-seq
MIRT2458690	hsa-miR-2054	CLIP-seq
MIRT2458691	hsa-miR-3143	CLIP-seq
MIRT2458692	hsa-miR-561	CLIP-seq
MIRT2465990	hsa-miR-548ac	CLIP-seq
MIRT2465991	hsa-miR-548ae	CLIP-seq
MIRT2465992	hsa-miR-548aj	CLIP-seq
MIRT2465993	hsa-miR-548am	CLIP-seq
MIRT2465994	hsa-miR-548d-3p	CLIP-seq
MIRT2465995	hsa-miR-548x	CLIP-seq
MIRT2465996	hsa-miR-548z	CLIP-seq
MIRT1321937	hsa-miR-147	CLIP-seq
MIRT1321938	hsa-miR-3140-3p	CLIP-seq
MIRT1321937	hsa-miR-147	CLIP-seq
MIRT1321938	hsa-miR-3140-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	12873973
GO:0005515	Function	Protein binding	IPI	12873973, 15286784, 17684057, 17786215
GO:0005783	Component	Endoplasmic reticulum	IDA	12873973
GO:0030176	Component	Integral component of endoplasmic reticulum membrane	TAS	8833145
GO:1902430	Process	Negative regulation of amyloid-beta formation	IDA	15286784

Other IDs

• MIM: 600865
• HGNC: 10467
• e!Ensembl: ENSG00000139970

Protein

• UniProt ID: Q16799
• Protein name: Reticulon-1 (Neuroendocrine-specific protein)
• Protein function: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02453	Reticulon	589 → 753	Reticulon	Family

• Sequence:

  MAAPGDPQDELLPLAGPGSQWLRHRGEGENEAVTPKGATPAPQAGEPSPGLGARAREAAS
  REAGSGPARQSPVAMETASTGVAGVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDS
  TYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNK
  ILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPD
  KPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKT
  PEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAI
  KEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDP
  MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES
  PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD
  GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ
  TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY
  LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN
  GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE

• Sequence length: 776

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	28991256, 30626913, 30285260, 26198764

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	30626913, 30718901
Myocardial ischemia	Myocardial Ischemia		16214533