RPS29 (ribosomal protein S29)

Gene

• Entrez ID: 6235
• Gene name: Ribosomal protein S29
• Gene symbol: RPS29
• Synonyms: DBA13, S29, uS14
• Chromosome: 14
• Chromosome location: 14q21.3
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016617	hsa-miR-484	Sequencing	20371350
MIRT027890	hsa-miR-96-5p	Sequencing	20371350
MIRT047627	hsa-miR-10a-5p	CLASH	23622248
MIRT039486	hsa-miR-652-3p	CLASH	23622248
MIRT1317956	hsa-miR-135a	CLIP-seq
MIRT1317957	hsa-miR-135b	CLIP-seq
MIRT1317958	hsa-miR-3119	CLIP-seq
MIRT1317959	hsa-miR-3124-3p	CLIP-seq
MIRT1317960	hsa-miR-4426	CLIP-seq
MIRT1317961	hsa-miR-4647	CLIP-seq
MIRT1317962	hsa-miR-4662b	CLIP-seq
MIRT1317963	hsa-miR-105	CLIP-seq
MIRT1317964	hsa-miR-1252	CLIP-seq
MIRT1317965	hsa-miR-1305	CLIP-seq
MIRT1317966	hsa-miR-186	CLIP-seq
MIRT1317967	hsa-miR-2681	CLIP-seq
MIRT1317968	hsa-miR-300	CLIP-seq
MIRT1317969	hsa-miR-3179	CLIP-seq
MIRT1317970	hsa-miR-3671	CLIP-seq
MIRT1317971	hsa-miR-381	CLIP-seq
MIRT1317972	hsa-miR-4666-3p	CLIP-seq
MIRT1317973	hsa-miR-500a	CLIP-seq
MIRT1317974	hsa-miR-520d-5p	CLIP-seq
MIRT1317975	hsa-miR-524-5p	CLIP-seq
MIRT1317976	hsa-miR-607	CLIP-seq
MIRT1317963	hsa-miR-105	CLIP-seq
MIRT1317970	hsa-miR-3671	CLIP-seq
MIRT1317976	hsa-miR-607	CLIP-seq
MIRT2094468	hsa-miR-1178	CLIP-seq
MIRT2094469	hsa-miR-1226	CLIP-seq
MIRT2094470	hsa-miR-1285	CLIP-seq
MIRT2094471	hsa-miR-150	CLIP-seq
MIRT2094472	hsa-miR-1587	CLIP-seq
MIRT2094473	hsa-miR-218	CLIP-seq
MIRT1317959	hsa-miR-3124-3p	CLIP-seq
MIRT2094474	hsa-miR-3138	CLIP-seq
MIRT2094475	hsa-miR-3147	CLIP-seq
MIRT2094476	hsa-miR-3180-5p	CLIP-seq
MIRT2094477	hsa-miR-3187-5p	CLIP-seq
MIRT2094478	hsa-miR-3619-3p	CLIP-seq
MIRT2094479	hsa-miR-3945	CLIP-seq
MIRT2094480	hsa-miR-409-3p	CLIP-seq
MIRT2094481	hsa-miR-4252	CLIP-seq
MIRT2094482	hsa-miR-4253	CLIP-seq
MIRT2094483	hsa-miR-4425	CLIP-seq
MIRT2094484	hsa-miR-455-5p	CLIP-seq
MIRT2094485	hsa-miR-4713-5p	CLIP-seq
MIRT2094486	hsa-miR-4733-3p	CLIP-seq
MIRT2094487	hsa-miR-4752	CLIP-seq
MIRT2094488	hsa-miR-4776-5p	CLIP-seq
MIRT2094489	hsa-miR-4781-3p	CLIP-seq
MIRT2094490	hsa-miR-4786-3p	CLIP-seq
MIRT2094491	hsa-miR-4800-5p	CLIP-seq
MIRT2094492	hsa-miR-511	CLIP-seq
MIRT2094493	hsa-miR-520a-5p	CLIP-seq
MIRT2094494	hsa-miR-525-5p	CLIP-seq
MIRT2094495	hsa-miR-532-3p	CLIP-seq
MIRT2094496	hsa-miR-612	CLIP-seq
MIRT2094497	hsa-miR-634	CLIP-seq
MIRT2094498	hsa-miR-636	CLIP-seq
MIRT2094499	hsa-miR-873	CLIP-seq
MIRT2094468	hsa-miR-1178	CLIP-seq
MIRT2094469	hsa-miR-1226	CLIP-seq
MIRT2318981	hsa-miR-1266	CLIP-seq
MIRT2094471	hsa-miR-150	CLIP-seq
MIRT2094472	hsa-miR-1587	CLIP-seq
MIRT2318982	hsa-miR-2392	CLIP-seq
MIRT2094475	hsa-miR-3147	CLIP-seq
MIRT2318983	hsa-miR-3187-3p	CLIP-seq
MIRT2318984	hsa-miR-3664-3p	CLIP-seq
MIRT2318985	hsa-miR-3682-3p	CLIP-seq
MIRT2094480	hsa-miR-409-3p	CLIP-seq
MIRT2094483	hsa-miR-4425	CLIP-seq
MIRT2318986	hsa-miR-4518	CLIP-seq
MIRT2318987	hsa-miR-4529-5p	CLIP-seq
MIRT2318988	hsa-miR-4674	CLIP-seq
MIRT2094485	hsa-miR-4713-5p	CLIP-seq
MIRT2094486	hsa-miR-4733-3p	CLIP-seq
MIRT2094489	hsa-miR-4781-3p	CLIP-seq
MIRT2094495	hsa-miR-532-3p	CLIP-seq
MIRT2094497	hsa-miR-634	CLIP-seq
MIRT2318989	hsa-miR-635	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0008270	Function	Zinc ion binding	IBA	21873635
GO:0008270	Function	Zinc ion binding	IDA	8781548, 25957688
GO:0015935	Component	Small ribosomal subunit	HDA	15883184
GO:0019083	Process	Viral transcription	TAS
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA	21873635
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699, 23636399
GO:0042788	Component	Polysomal ribosome	IDA	25957688
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0098556	Component	Cytoplasmic side of rough endoplasmic reticulum membrane	ISS

Other IDs

• MIM: 603633
• HGNC: 10419
• e!Ensembl: ENSG00000213741

Protein

• UniProt ID: P62273
• Protein name: Small ribosomal subunit protein uS14 (40S ribosomal protein S29)
• Protein function: Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957
• PDB: 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 5LKS, 5OA3, 5T2C, 5VYC, 6FEC, 6G51, 6G53, 6G5H, 6G5I, 6IP5, 6IP6, 6IP8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6XA1, 6Y0G, 6Y2L, 6Y57, 6YBS, 6Z6L, 6Z6M, 6Z6N, 6ZLW, 6ZM7, 6ZME, 6ZMI, 6ZMO, 6ZMT, 6ZMW, 6ZN5, 6ZOJ, 6ZOL, 6ZON, 6ZP4, 6ZUO, 6ZV6, 6ZVH, 6ZVJ, 6ZXD, 6ZXE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00253	Ribosomal_S14	6 → 55	Ribosomal protein S14p/S29e	Family

• Sequence:

  MGHQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFIKLD

• Sequence length: 56

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Anemia	Anemia, Macrocytic, Normocytic anemia, Anemia, Diamond-Blackfan	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505	24829207, 28297620
Diamond-blackfan anemia	DIAMOND-BLACKFAN ANEMIA 13	rs121434389, rs1570566590, rs151155897, rs143951267, rs267607023, rs786200892, rs148622862, rs397507554, rs121434405, rs1571026775, rs142156224, rs267607021, rs1581931541, rs267607022, rs61762293, rs104894711, rs104894716, rs121908649, rs786200935, rs786200936, rs104894188, rs104894189, rs116840806, rs116840811, rs116840812, rs116840808, rs116840809, rs397518451, rs6991, rs587777117, rs587777118, rs587777119, rs587777120, rs587777568, rs587777569, rs148942765, rs786203998, rs797045919, rs878854146, rs886039545, rs1057519624, rs144337183, rs138938035, rs1057520746, rs1060503527, rs1060503688, rs1085307115, rs1085307119, rs1064794604, rs1555841379, rs1553121909, rs1555208596, rs1555841301, rs1555841356, rs1553121678, rs1553121795, rs1553121684, rs1553811551, rs1554841994, rs1555524370, rs1555524354, rs1558283792, rs1558283853, rs1558284033, rs1558284062, rs1560120302, rs869066130, rs1568796003, rs1567287990, rs1568425218, rs1564307664, rs1570566592, rs148673599, rs1571024385, rs1571024430, rs1581931439, rs1589326484, rs1570569383, rs146366047, rs111833764, rs1571032029, rs1572360944, rs1581106084, rs138979590, rs1644516691, rs1686990557, rs1686990676, rs149420497, rs1765648528, rs113752862, rs1704930969, rs1553284997	24829207
Leukemia	Acute leukemia	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601
Migraine	Migraine Disorders	rs794727411

Unknown
Disease name	Disease term	dbSNP ID	References
Aase-smith syndrome	Aase Smith syndrome 2		24829207
Blackfan-diamond anemia	Blackfan-Diamond anemia
Dwarfism	Dwarfism