RPS18 (ribosomal protein S18)

Gene

• Entrez ID: 6222
• Gene name: Ribosomal protein S18
• Gene symbol: RPS18
• Synonyms: D6S218E, HKE3, KE-3, KE3, S18, uS13
• Chromosome: 6
• Chromosome location: 6p21.32
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050014	hsa-miR-27a-3p	CLASH	23622248
MIRT041672	hsa-miR-484	CLASH	23622248
MIRT041265	hsa-miR-193b-3p	CLASH	23622248
MIRT039415	hsa-miR-421	CLASH	23622248
MIRT439735	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439735	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT2318929	hsa-miR-3922-5p	CLIP-seq
MIRT2318930	hsa-miR-4477a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0005515	Function	Protein binding	IPI	22720776, 24725412, 31046837
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	22720776
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	NAS	8441687
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0015935	Component	Small ribosomal subunit	HDA	15883184
GO:0015935	Component	Small ribosomal subunit	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0019843	Function	RRNA binding	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337

Other IDs

• MIM: 180473
• HGNC: 10401
• e!Ensembl: ENSG00000231500

Protein

• UniProt ID: P62269
• Protein name: Small ribosomal subunit protein uS13 (40S ribosomal protein S18) (Ke-3) (Ke3)
• Protein function: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
• PDB: 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 5LKS, 5OA3, 5T2C, 5VYC, 6FEC, 6G18, 6G4S, 6G4W, 6G51, 6G53, 6G5H, 6G5I, 6IP5, 6IP6, 6IP8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6XA1, 6Y0G, 6Y2L, 6Y57, 6YBS, 6Z6L, 6Z6M, 6Z6N, 6ZLW, 6ZM7, 6ZME, 6ZMI, 6ZMO, 6ZMT, 6ZMW, 6ZN5, 6ZOJ, 6ZOL, 6ZON, 6ZP4, 6ZUO, 6ZV6, 6ZVH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00416	Ribosomal_S13	14 → 142	Ribosomal protein S13/S18	Family

• Sequence:

  MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELT
  EDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLREDLERLKKIRAH
  RGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK

• Sequence length: 152

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	19503088