RPS14 (ribosomal protein S14)

Gene

• Entrez ID: 6208
• Gene name: Ribosomal protein S14
• Gene symbol: RPS14
• Synonyms: EMTB, S14, uS11
• Chromosome: 5
• Chromosome location: 5q33.1
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050273	hsa-miR-25-3p	CLASH	23622248
MIRT049275	hsa-miR-92a-3p	CLASH	23622248
MIRT044278	hsa-miR-106b-5p	CLASH	23622248
MIRT043360	hsa-miR-331-3p	CLASH	23622248
MIRT043360	hsa-miR-331-3p	CLASH	23622248
MIRT041923	hsa-miR-484	CLASH	23622248
MIRT041170	hsa-miR-181d-5p	CLASH	23622248
MIRT040719	hsa-miR-92b-3p	CLASH	23622248
MIRT037567	hsa-miR-744-5p	CLASH	23622248
MIRT468959	hsa-miR-8060	PAR-CLIP	20371350
MIRT468957	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT468956	hsa-miR-4493	PAR-CLIP	20371350
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT468949	hsa-miR-4477a	PAR-CLIP	20371350
MIRT468948	hsa-miR-6126	PAR-CLIP	20371350
MIRT468959	hsa-miR-8060	PAR-CLIP	20371350
MIRT468957	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT468956	hsa-miR-4493	PAR-CLIP	20371350
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT468949	hsa-miR-4477a	PAR-CLIP	20371350
MIRT468948	hsa-miR-6126	PAR-CLIP	20371350
MIRT563169	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT563168	hsa-miR-4464	PAR-CLIP	20371350
MIRT563167	hsa-miR-4748	PAR-CLIP	20371350
MIRT563166	hsa-miR-455-5p	PAR-CLIP	20371350
MIRT563165	hsa-miR-3665	PAR-CLIP	20371350
MIRT563164	hsa-miR-657	PAR-CLIP	20371350
MIRT563163	hsa-miR-5087	PAR-CLIP	20371350
MIRT563162	hsa-miR-1227-3p	PAR-CLIP	20371350
MIRT563161	hsa-miR-8068	PAR-CLIP	20371350
MIRT563160	hsa-miR-3924	PAR-CLIP	20371350
MIRT563159	hsa-miR-4659a-5p	PAR-CLIP	20371350
MIRT563158	hsa-miR-4659b-5p	PAR-CLIP	20371350
MIRT468959	hsa-miR-8060	PAR-CLIP	23446348
MIRT468958	hsa-miR-494-3p	PAR-CLIP	23446348
MIRT468957	hsa-miR-605-3p	PAR-CLIP	23446348
MIRT468956	hsa-miR-4493	PAR-CLIP	23446348
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	23446348
MIRT468949	hsa-miR-4477a	PAR-CLIP	23446348
MIRT468948	hsa-miR-6126	PAR-CLIP	23446348
MIRT468947	hsa-miR-510-3p	PAR-CLIP	23446348
MIRT468959	hsa-miR-8060	PAR-CLIP	23592263
MIRT468958	hsa-miR-494-3p	PAR-CLIP	23592263
MIRT468957	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT468956	hsa-miR-4493	PAR-CLIP	23592263
MIRT468955	hsa-miR-219a-1-3p	PAR-CLIP	23592263
MIRT468954	hsa-miR-3135b	PAR-CLIP	23592263
MIRT468953	hsa-miR-4653-3p	PAR-CLIP	23592263
MIRT468952	hsa-miR-3652	PAR-CLIP	23592263
MIRT468951	hsa-miR-4430	PAR-CLIP	23592263
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	23592263
MIRT468949	hsa-miR-4477a	PAR-CLIP	23592263
MIRT468948	hsa-miR-6126	PAR-CLIP	23592263
MIRT468947	hsa-miR-510-3p	PAR-CLIP	23592263
MIRT468959	hsa-miR-8060	PAR-CLIP	20371350
MIRT468957	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT468956	hsa-miR-4493	PAR-CLIP	20371350
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT468949	hsa-miR-4477a	PAR-CLIP	20371350
MIRT468948	hsa-miR-6126	PAR-CLIP	20371350
MIRT468959	hsa-miR-8060	PAR-CLIP	20371350
MIRT468957	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT468956	hsa-miR-4493	PAR-CLIP	20371350
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT468949	hsa-miR-4477a	PAR-CLIP	20371350
MIRT468948	hsa-miR-6126	PAR-CLIP	20371350
MIRT563169	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT563168	hsa-miR-4464	PAR-CLIP	20371350
MIRT563167	hsa-miR-4748	PAR-CLIP	20371350
MIRT563166	hsa-miR-455-5p	PAR-CLIP	20371350
MIRT563165	hsa-miR-3665	PAR-CLIP	20371350
MIRT563164	hsa-miR-657	PAR-CLIP	20371350
MIRT563163	hsa-miR-5087	PAR-CLIP	20371350
MIRT563162	hsa-miR-1227-3p	PAR-CLIP	20371350
MIRT563161	hsa-miR-8068	PAR-CLIP	20371350
MIRT563160	hsa-miR-3924	PAR-CLIP	20371350
MIRT563159	hsa-miR-4659a-5p	PAR-CLIP	20371350
MIRT563158	hsa-miR-4659b-5p	PAR-CLIP	20371350
MIRT468959	hsa-miR-8060	PAR-CLIP	23446348
MIRT468958	hsa-miR-494-3p	PAR-CLIP	23446348
MIRT468957	hsa-miR-605-3p	PAR-CLIP	23446348
MIRT468956	hsa-miR-4493	PAR-CLIP	23446348
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	23446348
MIRT468949	hsa-miR-4477a	PAR-CLIP	23446348
MIRT468948	hsa-miR-6126	PAR-CLIP	23446348
MIRT468947	hsa-miR-510-3p	PAR-CLIP	23446348
MIRT468959	hsa-miR-8060	PAR-CLIP	23592263
MIRT468958	hsa-miR-494-3p	PAR-CLIP	23592263
MIRT468957	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT468956	hsa-miR-4493	PAR-CLIP	23592263
MIRT468955	hsa-miR-219a-1-3p	PAR-CLIP	23592263
MIRT468954	hsa-miR-3135b	PAR-CLIP	23592263
MIRT468953	hsa-miR-4653-3p	PAR-CLIP	23592263
MIRT468952	hsa-miR-3652	PAR-CLIP	23592263
MIRT468951	hsa-miR-4430	PAR-CLIP	23592263
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	23592263
MIRT468949	hsa-miR-4477a	PAR-CLIP	23592263
MIRT468948	hsa-miR-6126	PAR-CLIP	23592263
MIRT468947	hsa-miR-510-3p	PAR-CLIP	23592263
MIRT1317710	hsa-miR-4666-5p	CLIP-seq
MIRT1317711	hsa-miR-494	CLIP-seq
MIRT2094424	hsa-miR-1224-5p	CLIP-seq
MIRT2094425	hsa-miR-1304	CLIP-seq
MIRT2094426	hsa-miR-3915	CLIP-seq
MIRT2094427	hsa-miR-3928	CLIP-seq
MIRT2094428	hsa-miR-4689	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000028	Process	Ribosomal small subunit assembly	IBA	21873635
GO:0000028	Process	Ribosomal small subunit assembly	IMP	9152021
GO:0000028	Process	Ribosomal small subunit assembly	ISS
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	7867928
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0000462	Process	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA	21873635
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	ISS
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0005515	Function	Protein binding	IPI	24965446, 25009770, 25416956, 28514442, 30021884, 32296183
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	9152021
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006364	Process	RRNA processing	TAS
GO:0006412	Process	Translation	IBA	21873635
GO:0006412	Process	Translation	IC	3785212, 8706699, 15883184
GO:0006412	Process	Translation	IMP	3683397
GO:0006413	Process	Translational initiation	TAS
GO:0006417	Process	Regulation of translation	IEA
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA	21873635
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699, 9152021
GO:0030218	Process	Erythrocyte differentiation	IMP	18202658
GO:0030490	Process	Maturation of SSU-rRNA	ISS
GO:0045182	Function	Translation regulator activity	IMP	3683397
GO:0048027	Function	MRNA 5'-UTR binding	IBA	21873635
GO:0048027	Function	MRNA 5'-UTR binding	IDA	7867928
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070181	Function	Small ribosomal subunit rRNA binding	IBA	21873635

Other IDs

• MIM: 130620
• HGNC: 10387
• e!Ensembl: ENSG00000164587

Protein

• UniProt ID: P62263
• Protein name: Small ribosomal subunit protein uS11 (40S ribosomal protein S14)
• Protein function: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subu
• PDB: 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 5LKS, 5OA3, 5T2C, 5VYC, 6FEC, 6G18, 6G4S, 6G4W, 6G51, 6G53, 6G5H, 6G5I, 6IP5, 6IP6, 6IP8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6XA1, 6Y0G, 6Y2L, 6Y57, 6YBD, 6YBW, 6Z6L, 6Z6M, 6Z6N, 6ZLW, 6ZM7, 6ZME, 6ZMI, 6ZMO, 6ZMT, 6ZMW, 6ZN5, 6ZOJ, 6ZOK, 6ZON, 6ZP4, 6ZUO, 6ZV6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00411	Ribosomal_S11	29 → 147	Ribosomal protein S11	Family

• Sequence:

  MAPRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGM
  KVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALA
  RSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL

• Sequence length: 151

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Anemia	Anemia, Macrocytic	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	16316942
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601
Myelodysplasia	Myelodysplasia	rs141601766, rs1261178797
Myelodysplastic syndrome	Myelodysplastic Syndrome with Isolated del(5q), MYELODYSPLASTIC SYNDROME	rs193303018, rs387906631, rs1576745225, rs373145711, rs752746786, rs377023736, rs373221034, rs1576749014, rs1600586587	22571696
Neutropenia	Neutropenia	rs879253882	27725143

Unknown
Disease name	Disease term	dbSNP ID	References
5q-syndrome	5q-syndrome		22571696
Anaplastic carcinoma	Anaplastic carcinoma		16316942
Contiguous gene syndrome	Autosomal dominant contiguous gene syndrome
Erythroid hypoplasia	Erythroid hypoplasia
Leukopenia	Leukopenia
Macrocytic anemia	Refractory macrocytic anemia
Multiple lineage myelodysplasia	Multiple lineage myelodysplasia
Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality	Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality
Thrombocytosis	Thrombocytosis