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RPN2 (ribophorin II)

Gene

6185

Ribophorin II

RPN2

RIBIIR, RPN-II, RPNII, SWP1

20q11.23

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-S

Show/Hide all(179)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019733	hsa-miR-375	Microarray	20215506
MIRT051474	hsa-let-7e-5p	CLASH	23622248
MIRT049944	hsa-miR-30a-5p	CLASH	23622248
MIRT047806	hsa-miR-30d-5p	CLASH	23622248
MIRT046320	hsa-miR-23b-3p	CLASH	23622248
MIRT042274	hsa-miR-484	CLASH	23622248
MIRT042274	hsa-miR-484	CLASH	23622248
MIRT039690	hsa-miR-615-3p	CLASH	23622248
MIRT450694	hsa-miR-219a-2-3p	PAR-CLIP	22100165
MIRT450693	hsa-miR-4318	PAR-CLIP	22100165
MIRT450692	hsa-miR-892a	PAR-CLIP	22100165
MIRT450691	hsa-miR-1-5p	PAR-CLIP	22100165
MIRT450690	hsa-miR-219b-3p	PAR-CLIP	22100165
MIRT450689	hsa-miR-1257	PAR-CLIP	22100165
MIRT450688	hsa-miR-2116-5p	PAR-CLIP	22100165
MIRT450687	hsa-miR-22-5p	PAR-CLIP	22100165
MIRT450686	hsa-miR-4693-5p	PAR-CLIP	22100165
MIRT450685	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450684	hsa-miR-4273	PAR-CLIP	22100165
MIRT450683	hsa-miR-7156-5p	PAR-CLIP	22100165
MIRT450682	hsa-miR-4677-5p	PAR-CLIP	22100165
MIRT450681	hsa-miR-6739-3p	PAR-CLIP	22100165
MIRT450694	hsa-miR-219a-2-3p	PAR-CLIP	22100165
MIRT450693	hsa-miR-4318	PAR-CLIP	22100165
MIRT450692	hsa-miR-892a	PAR-CLIP	22100165
MIRT450691	hsa-miR-1-5p	PAR-CLIP	22100165
MIRT450690	hsa-miR-219b-3p	PAR-CLIP	22100165
MIRT450689	hsa-miR-1257	PAR-CLIP	22100165
MIRT450688	hsa-miR-2116-5p	PAR-CLIP	22100165
MIRT450687	hsa-miR-22-5p	PAR-CLIP	22100165
MIRT450686	hsa-miR-4693-5p	PAR-CLIP	22100165
MIRT450685	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450684	hsa-miR-4273	PAR-CLIP	22100165
MIRT450683	hsa-miR-7156-5p	PAR-CLIP	22100165
MIRT450682	hsa-miR-4677-5p	PAR-CLIP	22100165
MIRT450681	hsa-miR-6739-3p	PAR-CLIP	22100165
MIRT1317104	hsa-miR-1226	CLIP-seq
MIRT1317105	hsa-miR-128	CLIP-seq
MIRT1317106	hsa-miR-2110	CLIP-seq
MIRT1317107	hsa-miR-3200-5p	CLIP-seq
MIRT1317108	hsa-miR-3670	CLIP-seq
MIRT1317109	hsa-miR-3919	CLIP-seq
MIRT1317110	hsa-miR-3941	CLIP-seq
MIRT1317111	hsa-miR-4271	CLIP-seq
MIRT1317112	hsa-miR-4303	CLIP-seq
MIRT1317113	hsa-miR-4311	CLIP-seq
MIRT1317114	hsa-miR-466	CLIP-seq
MIRT1317115	hsa-miR-4672	CLIP-seq
MIRT1317116	hsa-miR-4725-3p	CLIP-seq
MIRT1317117	hsa-miR-4733-3p	CLIP-seq
MIRT1317118	hsa-miR-4738-3p	CLIP-seq
MIRT1317119	hsa-miR-4756-3p	CLIP-seq
MIRT1317120	hsa-miR-548l	CLIP-seq
MIRT1317121	hsa-miR-548n	CLIP-seq
MIRT1317122	hsa-miR-548p	CLIP-seq
MIRT1317123	hsa-miR-606	CLIP-seq
MIRT1317124	hsa-miR-4659a-3p	CLIP-seq
MIRT1317125	hsa-miR-4659b-3p	CLIP-seq
MIRT1317126	hsa-miR-587	CLIP-seq
MIRT1317127	hsa-miR-942	CLIP-seq
MIRT2094127	hsa-miR-1305	CLIP-seq
MIRT1317104	hsa-miR-1226	CLIP-seq
MIRT1317105	hsa-miR-128	CLIP-seq
MIRT2439974	hsa-miR-3147	CLIP-seq
MIRT1317107	hsa-miR-3200-5p	CLIP-seq
MIRT1317108	hsa-miR-3670	CLIP-seq
MIRT1317109	hsa-miR-3919	CLIP-seq
MIRT1317110	hsa-miR-3941	CLIP-seq
MIRT1317112	hsa-miR-4303	CLIP-seq
MIRT1317113	hsa-miR-4311	CLIP-seq
MIRT2439975	hsa-miR-4425	CLIP-seq
MIRT1317114	hsa-miR-466	CLIP-seq
MIRT1317115	hsa-miR-4672	CLIP-seq
MIRT2439976	hsa-miR-4686	CLIP-seq
MIRT1317117	hsa-miR-4733-3p	CLIP-seq
MIRT1317119	hsa-miR-4756-3p	CLIP-seq
MIRT1317104	hsa-miR-1226	CLIP-seq
MIRT1317105	hsa-miR-128	CLIP-seq
MIRT2614391	hsa-miR-1299	CLIP-seq
MIRT2614392	hsa-miR-142-5p	CLIP-seq
MIRT2614393	hsa-miR-181a	CLIP-seq
MIRT2614394	hsa-miR-181b	CLIP-seq
MIRT2614395	hsa-miR-181c	CLIP-seq
MIRT2614396	hsa-miR-181d	CLIP-seq
MIRT1317106	hsa-miR-2110	CLIP-seq
MIRT2439974	hsa-miR-3147	CLIP-seq
MIRT2614397	hsa-miR-3150a-3p	CLIP-seq
MIRT2614398	hsa-miR-3182	CLIP-seq
MIRT1317107	hsa-miR-3200-5p	CLIP-seq
MIRT1317108	hsa-miR-3670	CLIP-seq
MIRT2614399	hsa-miR-378	CLIP-seq
MIRT2614400	hsa-miR-378b	CLIP-seq
MIRT2614401	hsa-miR-378c	CLIP-seq
MIRT2614402	hsa-miR-378d	CLIP-seq
MIRT2614403	hsa-miR-378e	CLIP-seq
MIRT2614404	hsa-miR-378f	CLIP-seq
MIRT2614405	hsa-miR-378h	CLIP-seq
MIRT2614406	hsa-miR-378i	CLIP-seq
MIRT1317109	hsa-miR-3919	CLIP-seq
MIRT1317110	hsa-miR-3941	CLIP-seq
MIRT2614407	hsa-miR-3942-3p	CLIP-seq
MIRT2614408	hsa-miR-422a	CLIP-seq
MIRT2614409	hsa-miR-4262	CLIP-seq
MIRT1317111	hsa-miR-4271	CLIP-seq
MIRT1317112	hsa-miR-4303	CLIP-seq
MIRT1317113	hsa-miR-4311	CLIP-seq
MIRT2614410	hsa-miR-4328	CLIP-seq
MIRT2439975	hsa-miR-4425	CLIP-seq
MIRT2614411	hsa-miR-4638-3p	CLIP-seq
MIRT1317124	hsa-miR-4659a-3p	CLIP-seq
MIRT1317125	hsa-miR-4659b-3p	CLIP-seq
MIRT1317114	hsa-miR-466	CLIP-seq
MIRT1317115	hsa-miR-4672	CLIP-seq
MIRT2439976	hsa-miR-4686	CLIP-seq
MIRT1317116	hsa-miR-4725-3p	CLIP-seq
MIRT1317117	hsa-miR-4733-3p	CLIP-seq
MIRT1317118	hsa-miR-4738-3p	CLIP-seq
MIRT1317119	hsa-miR-4756-3p	CLIP-seq
MIRT2614412	hsa-miR-4782-5p	CLIP-seq
MIRT2614413	hsa-miR-516b	CLIP-seq
MIRT1317120	hsa-miR-548l	CLIP-seq
MIRT1317121	hsa-miR-548n	CLIP-seq
MIRT1317122	hsa-miR-548p	CLIP-seq
MIRT2614414	hsa-miR-561	CLIP-seq
MIRT1317126	hsa-miR-587	CLIP-seq
MIRT1317123	hsa-miR-606	CLIP-seq
MIRT2614415	hsa-miR-875-3p	CLIP-seq
MIRT1317104	hsa-miR-1226	CLIP-seq
MIRT1317105	hsa-miR-128	CLIP-seq
MIRT2614391	hsa-miR-1299	CLIP-seq
MIRT2614392	hsa-miR-142-5p	CLIP-seq
MIRT2614393	hsa-miR-181a	CLIP-seq
MIRT2614394	hsa-miR-181b	CLIP-seq
MIRT2614395	hsa-miR-181c	CLIP-seq
MIRT2614396	hsa-miR-181d	CLIP-seq
MIRT1317106	hsa-miR-2110	CLIP-seq
MIRT2439974	hsa-miR-3147	CLIP-seq
MIRT2614397	hsa-miR-3150a-3p	CLIP-seq
MIRT2614398	hsa-miR-3182	CLIP-seq
MIRT1317107	hsa-miR-3200-5p	CLIP-seq
MIRT1317108	hsa-miR-3670	CLIP-seq
MIRT2614399	hsa-miR-378	CLIP-seq
MIRT2614400	hsa-miR-378b	CLIP-seq
MIRT2614401	hsa-miR-378c	CLIP-seq
MIRT2614402	hsa-miR-378d	CLIP-seq
MIRT2614403	hsa-miR-378e	CLIP-seq
MIRT2614404	hsa-miR-378f	CLIP-seq
MIRT2614405	hsa-miR-378h	CLIP-seq
MIRT2614406	hsa-miR-378i	CLIP-seq
MIRT1317109	hsa-miR-3919	CLIP-seq
MIRT1317110	hsa-miR-3941	CLIP-seq
MIRT2614407	hsa-miR-3942-3p	CLIP-seq
MIRT2614408	hsa-miR-422a	CLIP-seq
MIRT2614409	hsa-miR-4262	CLIP-seq
MIRT1317111	hsa-miR-4271	CLIP-seq
MIRT1317112	hsa-miR-4303	CLIP-seq
MIRT1317113	hsa-miR-4311	CLIP-seq
MIRT2614410	hsa-miR-4328	CLIP-seq
MIRT2439975	hsa-miR-4425	CLIP-seq
MIRT2614411	hsa-miR-4638-3p	CLIP-seq
MIRT1317124	hsa-miR-4659a-3p	CLIP-seq
MIRT1317125	hsa-miR-4659b-3p	CLIP-seq
MIRT1317114	hsa-miR-466	CLIP-seq
MIRT1317115	hsa-miR-4672	CLIP-seq
MIRT2439976	hsa-miR-4686	CLIP-seq
MIRT1317116	hsa-miR-4725-3p	CLIP-seq
MIRT1317117	hsa-miR-4733-3p	CLIP-seq
MIRT1317118	hsa-miR-4738-3p	CLIP-seq
MIRT1317119	hsa-miR-4756-3p	CLIP-seq
MIRT2614412	hsa-miR-4782-5p	CLIP-seq
MIRT2614413	hsa-miR-516b	CLIP-seq
MIRT1317120	hsa-miR-548l	CLIP-seq
MIRT1317121	hsa-miR-548n	CLIP-seq
MIRT1317122	hsa-miR-548p	CLIP-seq
MIRT2614414	hsa-miR-561	CLIP-seq
MIRT1317126	hsa-miR-587	CLIP-seq
MIRT1317123	hsa-miR-606	CLIP-seq
MIRT2614415	hsa-miR-875-3p	CLIP-seq
MIRT1317127	hsa-miR-942	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000421	Component	Autophagosome membrane	IEA
GO:0004579	Function	Dolichyl-diphosphooligosaccharide-protein glycotransferase activity	NAS	15835887
GO:0005515	Function	Protein binding	IPI	24965446, 28169274, 29290612
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005791	Component	Rough endoplasmic reticulum	IEA
GO:0006464	Process	Cellular protein modification process	TAS	10660554
GO:0006487	Process	Protein N-linked glycosylation	IBA	21873635
GO:0006487	Process	Protein N-linked glycosylation	IDA	9642163
GO:0007568	Process	Aging	IEA
GO:0008250	Component	Oligosaccharyltransferase complex	IBA	21873635
GO:0008250	Component	Oligosaccharyltransferase complex	IDA	9642163
GO:0008250	Component	Oligosaccharyltransferase complex	TAS	15835887
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0018279	Process	Protein N-linked glycosylation via asparagine	NAS	15835887
GO:0018279	Process	Protein N-linked glycosylation via asparagine	TAS
GO:0042493	Process	Response to drug	IEA
GO:0043022	Function	Ribosome binding	IEA

MIM	HGNC	e!Ensembl
180490	10382	ENSG00000118705

Protein

UniProt ID

P04844

Protein name

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2)

Protein function

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr

PDB

6S7O , 6S7T , 8B6L , 8PN9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05817	Ribophorin_II	9 → 627	Oligosaccharyltransferase subunit Ribophorin II	Family

Sequence

MAPPGSSTVFLLALTIIASTWALTPTHYLTKHDVERLKASLDRPFTNLESAFYSIVGLSS
LGAQVPDAKKACTYIRSNLDPSNVDSLFYAAQASQALSGCEISISNETKDLLLAAVSEDS
SVTQIYHAVAALSGFGLPLASQEALSALTARLSKEETVLATVQALQTASHLSQQADLRSI
VEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEPSIKEDQVIQLMNAI
FSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLSQPL
TQATVKLEHAKSVASRATVLQKTSFTPVGDVFELNFMNVKFSSGYYDFLVEVEGDNRYIA
NTVELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQL
VDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASGTYT
LYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTV
VSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNMF
QTLKYLAILGSVTFLAGNRMLAQQAVKRTAH

Sequence length

631

Interactions

View interactions

	KEGG		Reactome
	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Protein processing in endoplasmic reticulum		Asparagine N-linked glycosylation

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	29064472

Show/Hide Unknown Diseases (3)

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		29064472
Prostatic neoplasms	Prostatic Neoplasms		17013881
Schizoaffective disorder	Schizoaffective Disorder		29064472

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