RPL37A (ribosomal protein L37a)

Gene

• Entrez ID: 6168
• Gene name: Ribosomal protein L37a
• Gene symbol: RPL37A
• Synonyms: L37A, eL43
• Chromosome: 2
• Chromosome location: 2q35
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049877	hsa-miR-31-5p	CLASH	23622248
MIRT048692	hsa-miR-99a-5p	CLASH	23622248
MIRT039731	hsa-miR-615-3p	CLASH	23622248
MIRT039039	hsa-miR-766-3p	CLASH	23622248
MIRT038552	hsa-miR-106b-3p	CLASH	23622248
MIRT690367	hsa-miR-3163	HITS-CLIP	23313552
MIRT690366	hsa-miR-1285-5p	HITS-CLIP	23313552
MIRT690365	hsa-miR-3973	HITS-CLIP	23313552
MIRT690364	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT690363	hsa-miR-520h	HITS-CLIP	23313552
MIRT690362	hsa-miR-499b-5p	HITS-CLIP	23313552
MIRT498756	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT498755	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT498754	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT498753	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT498752	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT690361	hsa-miR-6868-5p	HITS-CLIP	23313552
MIRT690360	hsa-miR-4468	HITS-CLIP	23313552
MIRT690359	hsa-miR-4771	HITS-CLIP	23313552
MIRT690358	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT690357	hsa-miR-6081	HITS-CLIP	23313552
MIRT690356	hsa-miR-1207-5p	HITS-CLIP	23313552
MIRT690355	hsa-miR-4763-3p	HITS-CLIP	23313552
MIRT690354	hsa-miR-4736	HITS-CLIP	23313552
MIRT690353	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT690352	hsa-miR-7150	HITS-CLIP	23313552
MIRT671292	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT671291	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT671290	hsa-miR-4486	HITS-CLIP	23824327
MIRT671289	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT671288	hsa-miR-4284	HITS-CLIP	23824327
MIRT671287	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671286	hsa-miR-4505	HITS-CLIP	23824327
MIRT671285	hsa-miR-5787	HITS-CLIP	23824327
MIRT671284	hsa-miR-585-3p	HITS-CLIP	23824327
MIRT671283	hsa-miR-1268a	HITS-CLIP	23824327
MIRT671282	hsa-miR-1268b	HITS-CLIP	23824327
MIRT671280	hsa-miR-7977	HITS-CLIP	23824327
MIRT671281	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT498757	hsa-miR-4717-5p	PAR-CLIP	24398324
MIRT498758	hsa-miR-15a-3p	PAR-CLIP	24398324
MIRT300347	hsa-miR-1295b-3p	PAR-CLIP	24398324
MIRT498756	hsa-miR-371b-5p	PAR-CLIP	24398324
MIRT498755	hsa-miR-373-5p	PAR-CLIP	24398324
MIRT498754	hsa-miR-616-5p	PAR-CLIP	24398324
MIRT498753	hsa-miR-371a-5p	PAR-CLIP	24398324
MIRT498752	hsa-miR-372-5p	PAR-CLIP	24398324
MIRT300344	hsa-miR-219b-5p	PAR-CLIP	24398324
MIRT300348	hsa-miR-5704	PAR-CLIP	24398324
MIRT690367	hsa-miR-3163	HITS-CLIP	23313552
MIRT690366	hsa-miR-1285-5p	HITS-CLIP	23313552
MIRT690365	hsa-miR-3973	HITS-CLIP	23313552
MIRT690364	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT690363	hsa-miR-520h	HITS-CLIP	23313552
MIRT690362	hsa-miR-499b-5p	HITS-CLIP	23313552
MIRT498756	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT498755	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT498754	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT498753	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT498752	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT690361	hsa-miR-6868-5p	HITS-CLIP	23313552
MIRT690360	hsa-miR-4468	HITS-CLIP	23313552
MIRT690359	hsa-miR-4771	HITS-CLIP	23313552
MIRT690358	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT690357	hsa-miR-6081	HITS-CLIP	23313552
MIRT690356	hsa-miR-1207-5p	HITS-CLIP	23313552
MIRT690355	hsa-miR-4763-3p	HITS-CLIP	23313552
MIRT690354	hsa-miR-4736	HITS-CLIP	23313552
MIRT690353	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT690352	hsa-miR-7150	HITS-CLIP	23313552
MIRT671292	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT671291	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT671290	hsa-miR-4486	HITS-CLIP	23824327
MIRT671289	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT671288	hsa-miR-4284	HITS-CLIP	23824327
MIRT671287	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671286	hsa-miR-4505	HITS-CLIP	23824327
MIRT671285	hsa-miR-5787	HITS-CLIP	23824327
MIRT671284	hsa-miR-585-3p	HITS-CLIP	23824327
MIRT671283	hsa-miR-1268a	HITS-CLIP	23824327
MIRT671282	hsa-miR-1268b	HITS-CLIP	23824327
MIRT671280	hsa-miR-7977	HITS-CLIP	23824327
MIRT671281	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT498757	hsa-miR-4717-5p	PAR-CLIP	24398324
MIRT498758	hsa-miR-15a-3p	PAR-CLIP	24398324
MIRT300347	hsa-miR-1295b-3p	PAR-CLIP	24398324
MIRT498756	hsa-miR-371b-5p	PAR-CLIP	24398324
MIRT498755	hsa-miR-373-5p	PAR-CLIP	24398324
MIRT498754	hsa-miR-616-5p	PAR-CLIP	24398324
MIRT498753	hsa-miR-371a-5p	PAR-CLIP	24398324
MIRT498752	hsa-miR-372-5p	PAR-CLIP	24398324
MIRT300344	hsa-miR-219b-5p	PAR-CLIP	24398324
MIRT300348	hsa-miR-5704	PAR-CLIP	24398324
MIRT1316928	hsa-miR-1273d	CLIP-seq
MIRT1316929	hsa-miR-2964a-5p	CLIP-seq
MIRT1316930	hsa-miR-3125	CLIP-seq
MIRT1316931	hsa-miR-371-5p	CLIP-seq
MIRT1316932	hsa-miR-3916	CLIP-seq
MIRT1316933	hsa-miR-4729	CLIP-seq
MIRT1316934	hsa-miR-4795-3p	CLIP-seq
MIRT1316935	hsa-miR-660	CLIP-seq
MIRT1316936	hsa-miR-877	CLIP-seq
MIRT1316928	hsa-miR-1273d	CLIP-seq
MIRT1316929	hsa-miR-2964a-5p	CLIP-seq
MIRT1316930	hsa-miR-3125	CLIP-seq
MIRT1316931	hsa-miR-371-5p	CLIP-seq
MIRT1316932	hsa-miR-3916	CLIP-seq
MIRT1316933	hsa-miR-4729	CLIP-seq
MIRT1316934	hsa-miR-4795-3p	CLIP-seq
MIRT1316935	hsa-miR-660	CLIP-seq
MIRT1316936	hsa-miR-877	CLIP-seq
MIRT1316928	hsa-miR-1273d	CLIP-seq
MIRT1316929	hsa-miR-2964a-5p	CLIP-seq
MIRT1316931	hsa-miR-371-5p	CLIP-seq
MIRT1316933	hsa-miR-4729	CLIP-seq
MIRT1316934	hsa-miR-4795-3p	CLIP-seq
MIRT1316935	hsa-miR-660	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	NAS	12962325
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0019083	Process	Viral transcription	TAS
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337

Other IDs

• MIM: 613314
• HGNC: 10348
• e!Ensembl: ENSG00000197756

Protein

• UniProt ID: P61513
• Protein name: Large ribosomal subunit protein eL43 (60S ribosomal protein L37a)
• Protein function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
• PDB: 4UG0, 4V6X, 5AJ0, 5LKS, 5T2C, 6IP5, 6IP6, 6IP8, 6LQM, 6LSR, 6LSS, 6LU8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6W6L, 6XA1, 6Y0G, 6Y2L, 6Y57, 6Y6X, 6Z6L, 6Z6M, 6Z6N, 6ZM7, 6ZME, 6ZMI, 6ZMO, 7BHP, 7F5S, 7OW7, 7XNX, 7XNY, 8A3D, 8FKZ, 8FL2, 8FL3, 8FL4, 8FL6, 8FL7, 8FL9, 8FLA, 8FLB, 8FLC, 8FLD, 8FLE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01780	Ribosomal_L37ae	4 → 88	Ribosomal L37ae protein family	Family

• Sequence:

  MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSC
  MKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ

• Sequence length: 92

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	26776603

Unknown
Disease name	Disease term	dbSNP ID	References
Sclerocystic ovaries	Sclerocystic Ovaries		21411543
Polycystic ovary syndrome	Polycystic Ovary Syndrome		21411543