RPL21 (ribosomal protein L21)

Gene

• Entrez ID: 6144
• Gene name: Ribosomal protein L21
• Gene symbol: RPL21
• Synonyms: HYPT12, L21, eL21
• Chromosome: 13
• Chromosome location: 13q12.2
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT031954	hsa-miR-16-5p	Proteomics	18668040
MIRT050909	hsa-miR-17-5p	CLASH	23622248
MIRT050593	hsa-miR-20a-5p	CLASH	23622248
MIRT048563	hsa-miR-100-5p	CLASH	23622248
MIRT046903	hsa-miR-221-3p	CLASH	23622248
MIRT045855	hsa-miR-128-3p	CLASH	23622248
MIRT044294	hsa-miR-106b-5p	CLASH	23622248
MIRT042180	hsa-miR-484	CLASH	23622248
MIRT040024	hsa-miR-615-3p	CLASH	23622248
MIRT039492	hsa-miR-652-3p	CLASH	23622248
MIRT439741	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439741	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1316221	hsa-miR-4257	CLIP-seq
MIRT1316221	hsa-miR-4257	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	24965446
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006412	Process	Translation	NAS	12962325
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA	21873635

Other IDs

• MIM: 603636
• HGNC: 10313
• e!Ensembl: ENSG00000122026

Protein

• UniProt ID: P46778
• Protein name: Large ribosomal subunit protein eL21 (60S ribosomal protein L21)
• Protein function: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636
• PDB: 4UG0, 4V6X, 5AJ0, 5LKS, 5T2C, 6IP5, 6IP6, 6IP8, 6LQM, 6LSR, 6LSS, 6LU8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6W6L, 6XA1, 6Y0G, 6Y2L, 6Y57, 6Y6X, 6Z6L, 6Z6M, 6Z6N, 6ZM7, 6ZME, 6ZMI, 6ZMO, 7BHP, 7F5S, 7OW7, 7QVP, 7XNX, 7XNY, 8A3D, 8FKP, 8FKQ, 8FKR, 8FKS, 8FKT, 8FKU, 8FKV, 8FKW, 8FKX, 8FKY, 8FKZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01157	Ribosomal_L21e	1 → 101	Ribosomal protein L21e	Family

• Sequence:

  MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGK
  TGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKRVKENDQKKKEAK
  EKGTWVQLKRQPAPPREAHFVRTNGKEPELLEPIPYEFMA

• Sequence length: 160

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Hypotrichosis	Hypotrichosis, HYPOTRICHOSIS 12	rs121434306, rs121434307, rs121434308, rs121434309, rs1325804776, rs267606775, rs786200875, rs1568062215, rs267606776, rs1462595806, rs267606777, rs267606659, rs2147483647, rs559648418, rs121917819, rs121917820, rs387906382, rs267606867, rs267606868, rs267606869, rs201868115, rs587776925, rs587777527, rs587777545, rs766783183, rs879255262, rs201249971, rs768448663, rs1566212378, rs1249530918, rs1260995701, rs1569039353, rs1827030121	21412954
Hypotrichosis simplex	Hypotrichosis simplex	rs121913026, rs201249971	21412954

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia