RPL12 (ribosomal protein L12)

Gene

• Entrez ID: 6136
• Gene name: Ribosomal protein L12
• Gene symbol: RPL12
• Synonyms: L12, uL11
• Chromosome: 9
• Chromosome location: 9q33.3
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT031402	hsa-miR-16-5p	Proteomics	18668040
MIRT051997	hsa-let-7b-5p	CLASH	23622248
MIRT051475	hsa-let-7e-5p	CLASH	23622248
MIRT046988	hsa-miR-218-5p	CLASH	23622248
MIRT046650	hsa-miR-222-3p	CLASH	23622248
MIRT046558	hsa-let-7g-5p	CLASH	23622248
MIRT041418	hsa-miR-193b-3p	CLASH	23622248
MIRT682960	hsa-miR-141-3p	HITS-CLIP	23706177
MIRT682959	hsa-miR-200a-3p	HITS-CLIP	23706177
MIRT682958	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682957	hsa-miR-335-5p	HITS-CLIP	23706177
MIRT682956	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682955	hsa-miR-939-3p	HITS-CLIP	23706177
MIRT682954	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682953	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT682952	hsa-miR-1285-3p	HITS-CLIP	23706177
MIRT682951	hsa-miR-3187-5p	HITS-CLIP	23706177
MIRT682950	hsa-miR-5189-5p	HITS-CLIP	23706177
MIRT682949	hsa-miR-612	HITS-CLIP	23706177
MIRT682948	hsa-miR-6860	HITS-CLIP	23706177
MIRT682947	hsa-miR-661	HITS-CLIP	23706177
MIRT682946	hsa-miR-31-5p	HITS-CLIP	23706177
MIRT682945	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682944	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682943	hsa-miR-7703	HITS-CLIP	23706177
MIRT682942	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT446160	hsa-miR-134-3p	PAR-CLIP	22100165
MIRT446159	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT446158	hsa-miR-873-3p	PAR-CLIP	22100165
MIRT446157	hsa-miR-4747-5p	PAR-CLIP	22100165
MIRT446156	hsa-miR-5196-5p	PAR-CLIP	22100165
MIRT446155	hsa-miR-4648	PAR-CLIP	22100165
MIRT446154	hsa-miR-1233-5p	PAR-CLIP	22100165
MIRT446153	hsa-miR-6778-5p	PAR-CLIP	22100165
MIRT446152	hsa-miR-4654	PAR-CLIP	22100165
MIRT446150	hsa-miR-4769-5p	PAR-CLIP	22100165
MIRT446151	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT446149	hsa-miR-3672	PAR-CLIP	22100165
MIRT446148	hsa-miR-6864-3p	PAR-CLIP	22100165
MIRT446149	hsa-miR-3672	PAR-CLIP	27292025
MIRT446148	hsa-miR-6864-3p	PAR-CLIP	27292025
MIRT682960	hsa-miR-141-3p	HITS-CLIP	23706177
MIRT682959	hsa-miR-200a-3p	HITS-CLIP	23706177
MIRT682958	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682957	hsa-miR-335-5p	HITS-CLIP	23706177
MIRT682956	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682955	hsa-miR-939-3p	HITS-CLIP	23706177
MIRT682954	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682953	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT682952	hsa-miR-1285-3p	HITS-CLIP	23706177
MIRT682951	hsa-miR-3187-5p	HITS-CLIP	23706177
MIRT682950	hsa-miR-5189-5p	HITS-CLIP	23706177
MIRT682949	hsa-miR-612	HITS-CLIP	23706177
MIRT682948	hsa-miR-6860	HITS-CLIP	23706177
MIRT682947	hsa-miR-661	HITS-CLIP	23706177
MIRT682946	hsa-miR-31-5p	HITS-CLIP	23706177
MIRT682945	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682944	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682943	hsa-miR-7703	HITS-CLIP	23706177
MIRT682942	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT446160	hsa-miR-134-3p	PAR-CLIP	22100165
MIRT446159	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT446158	hsa-miR-873-3p	PAR-CLIP	22100165
MIRT446157	hsa-miR-4747-5p	PAR-CLIP	22100165
MIRT446156	hsa-miR-5196-5p	PAR-CLIP	22100165
MIRT446155	hsa-miR-4648	PAR-CLIP	22100165
MIRT446154	hsa-miR-1233-5p	PAR-CLIP	22100165
MIRT446153	hsa-miR-6778-5p	PAR-CLIP	22100165
MIRT446152	hsa-miR-4654	PAR-CLIP	22100165
MIRT446150	hsa-miR-4769-5p	PAR-CLIP	22100165
MIRT446151	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT446149	hsa-miR-3672	PAR-CLIP	22100165
MIRT446148	hsa-miR-6864-3p	PAR-CLIP	22100165
MIRT1315858	hsa-miR-105	CLIP-seq
MIRT1315859	hsa-miR-203	CLIP-seq
MIRT1315860	hsa-miR-4307	CLIP-seq
MIRT1315861	hsa-miR-501-5p	CLIP-seq
MIRT1315858	hsa-miR-105	CLIP-seq
MIRT1315859	hsa-miR-203	CLIP-seq
MIRT1315861	hsa-miR-501-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	22314232
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IBA	21873635
GO:0006412	Process	Translation	NAS	12962325
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0015934	Component	Large ribosomal subunit	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070180	Function	Large ribosomal subunit rRNA binding	IBA	21873635

Other IDs

• MIM: 180475
• HGNC: 10302
• e!Ensembl: ENSG00000197958

Protein

• UniProt ID: P30050
• Protein name: Large ribosomal subunit protein uL11 (60S ribosomal protein L12)
• Protein function: Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680). {ECO:00
• PDB: 4V6X, 5A8L, 5AJ0, 6OLG, 6ZM7, 6ZME, 6ZMI, 6ZMO, 7VB2, 8FKR, 8FKS, 8FKT, 8FKU, 8FKV, 8FKW, 8FKX, 8FKY, 8FKZ, 8FL0, 8FL2, 8FL3, 8FL4, 8FL6, 8FL7, 8FL9, 8FLA, 8FLB, 8FLC, 8G5Z, 8G60, 8G6J, 8IDT, 8IDY, 8INE, 8INF, 8INK, 8IPD, 8IPX, 8IPY, 8IR1, 8IR3, 8K2C, 8RL2, 8UKB, 8XSX, 8XSY, 8XSZ, 8YOO, 8YOP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03946	Ribosomal_L11_N	3 → 69	Ribosomal protein L11, N-terminal domain	Domain
  PF00298	Ribosomal_L11	73 → 143	Ribosomal protein L11, RNA binding domain	Domain

• Sequence:

  MPPKFDPNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRITV
  KLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIVNIARQMRHRS
  LARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPAS

• Sequence length: 165

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881