RPL5 (ribosomal protein L5)

Gene

• Entrez ID: 6125
• Gene name: Ribosomal protein L5
• Gene symbol: RPL5
• Synonyms: L5, MSTP030, PPP1R135, uL18
• Chromosome: 1
• Chromosome location: 1p22.1
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT031631	hsa-miR-16-5p	Proteomics	18668040
MIRT048387	hsa-miR-100-5p	CLASH	23622248
MIRT047180	hsa-miR-182-5p	CLASH	23622248
MIRT045009	hsa-miR-186-5p	CLASH	23622248
MIRT045009	hsa-miR-186-5p	CLASH	23622248
MIRT043744	hsa-miR-328-3p	CLASH	23622248
MIRT041938	hsa-miR-484	CLASH	23622248
MIRT040235	hsa-miR-615-3p	CLASH	23622248
MIRT038731	hsa-miR-93-3p	CLASH	23622248
MIRT367234	hsa-miR-548c-3p	HITS-CLIP	21572407
MIRT516264	hsa-miR-3200-5p	HITS-CLIP	21572407
MIRT516263	hsa-miR-4766-5p	HITS-CLIP	21572407
MIRT516262	hsa-miR-1206	HITS-CLIP	21572407
MIRT516261	hsa-miR-6853-3p	HITS-CLIP	21572407
MIRT516260	hsa-miR-4795-3p	HITS-CLIP	21572407
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	20371350
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT516262	hsa-miR-1206	PAR-CLIP	20371350
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	20371350
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	20371350
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT516262	hsa-miR-1206	PAR-CLIP	20371350
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	20371350
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	23446348
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	23446348
MIRT516262	hsa-miR-1206	PAR-CLIP	23446348
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	23446348
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	23446348
MIRT439736	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT439736	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT367234	hsa-miR-548c-3p	HITS-CLIP	21572407
MIRT516264	hsa-miR-3200-5p	HITS-CLIP	21572407
MIRT516263	hsa-miR-4766-5p	HITS-CLIP	21572407
MIRT516262	hsa-miR-1206	HITS-CLIP	21572407
MIRT516261	hsa-miR-6853-3p	HITS-CLIP	21572407
MIRT516260	hsa-miR-4795-3p	HITS-CLIP	21572407
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	20371350
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT516262	hsa-miR-1206	PAR-CLIP	20371350
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	20371350
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	20371350
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT516262	hsa-miR-1206	PAR-CLIP	20371350
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	20371350
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	23446348
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	23446348
MIRT516262	hsa-miR-1206	PAR-CLIP	23446348
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	23446348
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	23446348

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000027	Process	Ribosomal large subunit assembly	IBA	21873635
GO:0000027	Process	Ribosomal large subunit assembly	IMP	24120868
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003730	Function	MRNA 3'-UTR binding	IDA	16213212
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	IMP	18697920
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	9465063, 9687515, 12054647, 15314173, 15469983, 16648475, 17110929, 17373842, 18560357, 20434207, 20926688, 21399665
GO:0005634	Component	Nucleus	IDA	9687515
GO:0005654	Component	Nucleoplasm	IDA	24120868
GO:0005730	Component	Nucleolus	HDA	16791210
GO:0005730	Component	Nucleolus	IDA	15469983, 24120868
GO:0005737	Component	Cytoplasm	HDA	16791210
GO:0005737	Component	Cytoplasm	IDA	15314173, 15469983
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006364	Process	RRNA processing	IMP	18697920
GO:0006412	Process	Translation	NAS	12962325
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0008097	Function	5S rRNA binding	IBA	21873635
GO:0008097	Function	5S rRNA binding	IDA	18560357
GO:0010628	Process	Positive regulation of gene expression	IDA	18560357
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA	21873635
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	18560357
GO:0032991	Component	Protein-containing complex	IDA	15314173
GO:0042273	Process	Ribosomal large subunit biogenesis	IMP	18697920
GO:0045727	Process	Positive regulation of translation	IDA	16213212
GO:0048027	Function	MRNA 5'-UTR binding	IDA	16213212
GO:0050821	Process	Protein stabilization	IMP	18560357
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	IMP	24120868
GO:1904667	Process	Negative regulation of ubiquitin protein ligase activity	IDA	18560357
GO:1990904	Component	Ribonucleoprotein complex	IDA	18809582
GO:1990948	Function	Ubiquitin ligase inhibitor activity	IDA	18560357
GO:2000059	Process	Negative regulation of ubiquitin-dependent protein catabolic process	IDA	18560357
GO:2000435	Process	Negative regulation of protein neddylation	IDA	18560357

Other IDs

• MIM: 603634
• HGNC: 10360
• e!Ensembl: ENSG00000122406

Protein

• UniProt ID: P46777
• Protein name: Large ribosomal subunit protein uL18 (60S ribosomal protein L5)
• Protein function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-
• PDB: 4UG0, 4V6X, 5AJ0, 5LKS, 5T2C, 6IP5, 6IP6, 6IP8, 6LQM, 6LSR, 6LSS, 6LU8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6W6L, 6XA1, 6Y0G, 6Y2L, 6Y57, 6Y6X, 6Z6L, 6Z6M, 6Z6N, 6ZM7, 6ZME, 6ZMI, 6ZMO, 7BHP, 7F5S, 7OW7, 7QVP, 7XNX, 7XNY, 8A3D, 8BGU, 8FL0, 8FL2, 8FL3, 8FL4, 8FL6, 8FL7, 8FL9, 8FLA, 8FLB, 8FLC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17144	Ribosomal_L5e	14 → 176	Ribosomal large subunit proteins 60S L5, and 50S L18	Family
  PF14204	Ribosomal_L18_c	192 → 283	Ribosomal L18 C-terminal region	Domain

• Sequence:

  MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDI
  ICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYE
  GQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRF
  PGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMY
  KKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES

• Sequence length: 297

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Anemia	Anemia, Macrocytic, Anemia, Diamond-Blackfan	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505	28297620, 19061985, 19191325, 23718193, 19773262
Aplastic anemia	Aplastic Anemia	rs113993991, rs113993993, rs864309668, rs121908974, rs199422265, rs199422270, rs104894176, rs104894180, rs28933973, rs104894182, rs28933376, rs771552960, rs786205093, rs193302876, rs113993992, rs113993994, rs113993998, rs199422298, rs199422305, rs199422273, rs199422275, rs199422276, rs199422259, rs199422279, rs199422280, rs199422281, rs199422283, rs587780100, rs587781305, rs587781891, rs587781969, rs587782130, rs587782545, rs730881864, rs730881857, rs730881850, rs730881839, rs142301194, rs786201745, rs764884516, rs786202490, rs768378152, rs574673404, rs767215758, rs786205135, rs762664474, rs751161742, rs373730800, rs864622143, rs864622090, rs864622511, rs864622253, rs786201965, rs756363734, rs766044684, rs876659521, rs876659592, rs113993990, rs751247865, rs1057517262, rs1057516668, rs1057516611, rs1057516320, rs1057516772, rs931715719, rs767454740, rs1057519587, rs1060503483, rs1060503467, rs1064795816, rs1064793210, rs1131691842, rs772797192, rs751567476, rs780235686, rs1554562083, rs578092914, rs147035858, rs189650890, rs759232053, rs1554558613, rs1554567892, rs1554564297, rs1554558472, rs1554559083, rs1349928568, rs1178384498, rs1198614767, rs1554558449, rs1554568427, rs752858869, rs147462227, rs748513310, rs1238152597, rs760237820, rs1554562110, rs750375741, rs758708229, rs768849283, rs1563578540, rs1563526747, rs1563559078, rs772005832, rs1563539146, rs778306619, rs771475965, rs1586052851, rs1554559094, rs776571416, rs200430442, rs776299562, rs1584439050, rs1586075907, rs1586101154, rs1586059584, rs1586088924, rs1810540992, rs772411713, rs1812023981
Atrial septal defect	Atrial Septal Defects	rs137852951, rs137852953, rs137852955, rs267607106, rs104893900, rs104893901, rs104893903, rs606231358, rs606231359, rs137852683, rs606231360, rs104893907, rs104894073, rs1585703301, rs104894074, rs267606903, rs121912677, rs387906585, rs387906773, rs72554028, rs587782928, rs587782929, rs587782930, rs587784067, rs1555226315, rs879253754, rs1114167356, rs773922431, rs1554093487, rs1554093433, rs1554093461, rs1561621507, rs1561619801, rs766692577, rs1581108237, rs1581111034, rs1579663872, rs1583066622, rs1456289029, rs1761430125
Diamond-blackfan anemia	Diamond-Blackfan Anemia 1	rs121434389, rs1570566590, rs151155897, rs143951267, rs267607023, rs786200892, rs148622862, rs397507554, rs121434405, rs1571026775, rs142156224, rs267607021, rs1581931541, rs267607022, rs61762293, rs104894711, rs104894716, rs121908649, rs786200935, rs786200936, rs104894188, rs104894189, rs116840806, rs116840811, rs116840812, rs116840808, rs116840809, rs397518451, rs6991, rs587777117, rs587777118, rs587777119, rs587777120, rs587777568, rs587777569, rs148942765, rs786203998, rs797045919, rs878854146, rs886039545, rs1057519624, rs144337183, rs138938035, rs1057520746, rs1060503527, rs1060503688, rs1085307115, rs1085307119, rs1064794604, rs1555841379, rs1553121909, rs1555208596, rs1555841301, rs1555841356, rs1553121678, rs1553121795, rs1553121684, rs1553811551, rs1554841994, rs1555524370, rs1555524354, rs1558283792, rs1558283853, rs1558284033, rs1558284062, rs1560120302, rs869066130, rs1568796003, rs1567287990, rs1568425218, rs1564307664, rs1570566592, rs148673599, rs1571024385, rs1571024430, rs1581931439, rs1589326484, rs1570569383, rs146366047, rs111833764, rs1571032029, rs1572360944, rs1581106084, rs138979590, rs1644516691, rs1686990557, rs1686990676, rs149420497, rs1765648528, rs113752862, rs1704930969, rs1553284997
Hemangioma	Hemangioma	rs119475040, rs121917766
Leukemia	Acute leukemia	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601
Lymphoblastic leukemia	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591	23263491
Macrocephaly	Relative macrocephaly	rs786204854, rs764333096, rs1557739557
Migraine	Migraine Disorders	rs794727411
Mitral valve prolapse	Mitral Valve Prolapse Syndrome	rs768737101
Multiple congenital anomalies	Multiple congenital anomalies	rs1057517732	19061985
Patent ductus arteriosus	Patent ductus arteriosus	rs80338911, rs879253870, rs879253871, rs879255278, rs879255279, rs879253872
Pulmonary arterial hypertension	Pulmonary arterial hypertension	rs121909288, rs137852741, rs137852742, rs137852743, rs137852744, rs137852745, rs137852746, rs137852748, rs137852749, rs137852750, rs137852751, rs137852753, rs863223423, rs863223426, rs863223424, rs863223408, rs869025366, rs876657748, rs886039506, rs886041324, rs1060502576, rs1060502581, rs1060502584, rs1085307149, rs1085307154, rs1085307157, rs1085307163, rs1085307169, rs1085307177, rs1085307180, rs1085307184, rs1085307188, rs1085307191, rs1085307203, rs1085307222, rs1085307223, rs1085307225, rs1085307229, rs1085307234, rs1085307246, rs1085307261, rs1085307267, rs576091247, rs200948870, rs1085307278, rs1085307282, rs1085307285, rs1085307290, rs1085307301, rs1085307306, rs1085307307, rs1085307308, rs1085307315, rs1085307316, rs1553509997, rs1085307324, rs1085307340, rs1085307349, rs1085307352, rs765887545, rs1085307183, rs1555208696, rs1592224412, rs1574415785, rs1574415799, rs1574462520, rs1085307197, rs1574464060, rs749485755, rs1574464121, rs1574464150, rs1574464160, rs1085307214, rs1574485996, rs1574486497, rs1574486566, rs1574488314, rs1574488346, rs1574488353, rs1574488357, rs1574488412, rs1414031345, rs1574488484, rs1574488490, rs863223419, rs1574489046, rs1574494632, rs1574494655, rs1574500018, rs1574505253, rs1574505321, rs371174955, rs1574506729, rs1574506732, rs1574506781, rs1574506790, rs1574506799, rs1574506914, rs1574506976, rs1574507076, rs1574507124, rs1574507215, rs1574507268, rs1574507272, rs1574507276, rs1574507290, rs1574507331, rs398123042, rs374644720, rs1588573831, rs1592222308, rs1592223392, rs756315327, rs1603248167, rs1397811125, rs1603255267, rs1603255327, rs1603255336, rs1603255339, rs754897911, rs1603256095, rs1085307155, rs1085307156, rs1574464226, rs1085307226, rs1574486038, rs1553508321, rs1574488277, rs1574488501, rs1574493841, rs1574499954
Tetralogy of fallot	Tetralogy of Fallot	rs28939668, rs727504412, rs864321649, rs774966208, rs876660981, rs886044220, rs1114167357, rs1569484126, rs1569484164, rs1569484122, rs1569484124, rs1569484042, rs1569484120, rs1569484299, rs1569484301, rs1569484288
Ventricular septal defect	Ventricular Septal Defects	rs104894073, rs387906775

Unknown
Disease name	Disease term	dbSNP ID	References
Aase-smith syndrome	Aase Smith syndrome 2		19191325, 19061985
Blackfan-diamond anemia	Blackfan-Diamond anemia
Aplasia of the ovary	Congenital absence of ovary
Corpus luteum cyst	Corpus Luteum Cyst		21239663
Dwarfism	Dwarfism
Erythroid hypoplasia	Erythroid hypoplasia
Hypoplasia of thumb	Hypoplasia of thumb
Leukopenia	Leukopenia
Micrognathism	Micrognathism
Microspherocytosis	Microspherocytosis
Ovarian cysts	Ovarian Cysts		21239663
Testicular hydrocele	Testicular Hydrocele
Tracheomalacia	Tracheomalacia
Ventricular hypertrophy	Ventricular hypertrophy