RORB (RAR related orphan receptor B)

Gene

• Entrez ID: 6096
• Gene name: RAR related orphan receptor B
• Gene symbol: RORB
• Synonyms: EIG15, NR1F2, ROR-BETA, RORbeta, RZR-BETA, RZRB, bA133M9.1
• Chromosome: 9
• Chromosome location: 9q21.13
• Summary: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of th

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018866	hsa-miR-335-5p	Microarray	18185580
MIRT030014	hsa-miR-26b-5p	Microarray	19088304
MIRT673000	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT672999	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT672998	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT654163	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT654162	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT654161	hsa-miR-4282	HITS-CLIP	23824327
MIRT654160	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT654159	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT654158	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT654157	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT654156	hsa-miR-623	HITS-CLIP	23824327
MIRT654163	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT654162	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT654161	hsa-miR-4282	HITS-CLIP	23824327
MIRT654160	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT654159	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT654158	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT654157	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT654156	hsa-miR-623	HITS-CLIP	23824327
MIRT654155	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT654154	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT654153	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT673000	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT672999	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT672998	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT654163	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT654162	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT654161	hsa-miR-4282	HITS-CLIP	23824327
MIRT654160	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT654159	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT654158	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT654157	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT654156	hsa-miR-623	HITS-CLIP	23824327
MIRT654163	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT654162	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT654161	hsa-miR-4282	HITS-CLIP	23824327
MIRT654160	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT654159	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT654158	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT654157	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT654156	hsa-miR-623	HITS-CLIP	23824327
MIRT654155	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT654154	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT654153	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1315250	hsa-miR-1197	CLIP-seq
MIRT1315251	hsa-miR-1255a	CLIP-seq
MIRT1315252	hsa-miR-1255b	CLIP-seq
MIRT1315253	hsa-miR-137	CLIP-seq
MIRT1315254	hsa-miR-142-5p	CLIP-seq
MIRT1315255	hsa-miR-181a	CLIP-seq
MIRT1315256	hsa-miR-181b	CLIP-seq
MIRT1315257	hsa-miR-181c	CLIP-seq
MIRT1315258	hsa-miR-181d	CLIP-seq
MIRT1315259	hsa-miR-186	CLIP-seq
MIRT1315260	hsa-miR-3064-3p	CLIP-seq
MIRT1315261	hsa-miR-3133	CLIP-seq
MIRT1315262	hsa-miR-3171	CLIP-seq
MIRT1315263	hsa-miR-323-3p	CLIP-seq
MIRT1315264	hsa-miR-340	CLIP-seq
MIRT1315265	hsa-miR-4252	CLIP-seq
MIRT1315266	hsa-miR-4262	CLIP-seq
MIRT1315267	hsa-miR-4436a	CLIP-seq
MIRT1315268	hsa-miR-448	CLIP-seq
MIRT1315269	hsa-miR-4514	CLIP-seq
MIRT1315270	hsa-miR-4517	CLIP-seq
MIRT1315271	hsa-miR-4633-5p	CLIP-seq
MIRT1315272	hsa-miR-4692	CLIP-seq
MIRT1315273	hsa-miR-4694-3p	CLIP-seq
MIRT1315274	hsa-miR-4699-3p	CLIP-seq
MIRT1315275	hsa-miR-4715-3p	CLIP-seq
MIRT1315276	hsa-miR-522	CLIP-seq
MIRT1315277	hsa-miR-532-5p	CLIP-seq
MIRT1315278	hsa-miR-548g	CLIP-seq
MIRT1315279	hsa-miR-665	CLIP-seq
MIRT2093779	hsa-miR-376c	CLIP-seq
MIRT1315270	hsa-miR-4517	CLIP-seq
MIRT2318182	hsa-miR-3136-5p	CLIP-seq
MIRT2318183	hsa-miR-3140-3p	CLIP-seq
MIRT2318184	hsa-miR-376a	CLIP-seq
MIRT2318185	hsa-miR-376b	CLIP-seq
MIRT2318186	hsa-miR-4293	CLIP-seq
MIRT2318187	hsa-miR-4439	CLIP-seq
MIRT2318188	hsa-miR-4513	CLIP-seq
MIRT2458528	hsa-miR-1264	CLIP-seq
MIRT2458529	hsa-miR-133a	CLIP-seq
MIRT2458530	hsa-miR-133b	CLIP-seq
MIRT2458531	hsa-miR-3200-3p	CLIP-seq
MIRT2458532	hsa-miR-3613-3p	CLIP-seq
MIRT2458533	hsa-miR-432	CLIP-seq
MIRT2458534	hsa-miR-4535	CLIP-seq
MIRT2458535	hsa-miR-4776-5p	CLIP-seq
MIRT2458536	hsa-miR-492	CLIP-seq
MIRT2458528	hsa-miR-1264	CLIP-seq
MIRT2458529	hsa-miR-133a	CLIP-seq
MIRT2458530	hsa-miR-133b	CLIP-seq
MIRT2458531	hsa-miR-3200-3p	CLIP-seq
MIRT2458532	hsa-miR-3613-3p	CLIP-seq
MIRT2458533	hsa-miR-432	CLIP-seq
MIRT2458534	hsa-miR-4535	CLIP-seq
MIRT2458535	hsa-miR-4776-5p	CLIP-seq
MIRT2458536	hsa-miR-492	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISS
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0003700	Function	DNA-binding transcription factor activity	ISS
GO:0004879	Function	Nuclear receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	23555304
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA	27352968
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of transcription, DNA-templated	TAS	7935491
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007601	Process	Visual perception	IEA
GO:0008134	Function	Transcription factor binding	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008502	Function	Melatonin receptor activity	IBA	21873635
GO:0030522	Process	Intracellular receptor signaling pathway	IEA
GO:0035881	Process	Amacrine cell differentiation	ISS
GO:0042462	Process	Eye photoreceptor cell development	ISS
GO:0042752	Process	Regulation of circadian rhythm	ISS
GO:0045668	Process	Negative regulation of osteoblast differentiation	ISS
GO:0045892	Process	Negative regulation of transcription, DNA-templated	ISS
GO:0045893	Process	Positive regulation of transcription, DNA-templated	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046548	Process	Retinal rod cell development	ISS
GO:0046549	Process	Retinal cone cell development	ISS
GO:0048511	Process	Rhythmic process	IEA
GO:0060041	Process	Retina development in camera-type eye	ISS
GO:0071300	Process	Cellular response to retinoic acid	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 601972
• HGNC: 10259
• e!Ensembl: ENSG00000198963

Protein

• UniProt ID: Q92753
• Protein name: Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)
• Protein function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural li
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00105	zf-C4	19 → 88	Zinc finger, C4 type (two domains)	Domain
  PF00104	Hormone_recep	259 → 443	Ligand-binding domain of nuclear hormone receptor	Domain

• Sequence:

  MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQ
  RNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQ
  QQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSG
  LDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQY
  TMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQN
  DQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNL
  CSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKL
  IAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK

• Sequence length: 470

Pathways

KEGG:

Circadian rhythm

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074
Seizure	Tonic - clonic seizures	rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061, rs121912707, rs118192249, rs118192251, rs118192217, rs118192218, rs118192219, rs118192222, rs118192226, rs118192228, rs118192234, rs118192236, rs118192235, rs118192241, rs118192242, rs118192185, rs118192188, rs118192245, rs118192246, rs118192186, rs118192194, rs118192197, rs118192199, rs118192201, rs118192202, rs118192203, rs118192204, rs118192205, rs118192206, rs118192208, rs118192211, rs118192216, rs118192239, rs387906684, rs387906686, rs387906687, rs1596893185, rs387907126, rs387907281, rs397515405, rs587778771, rs730882067, rs730882073, rs397514579, rs397514582, rs587776976, rs398122394, rs121918784, rs121918751, rs121918735, rs398123588, rs587780450, rs61749751, rs587777620, rs727503974, rs730882124, rs794726710, rs794726697, rs794726799, rs794727444, rs794727740, rs796053166, rs794726825, rs796052676, rs796053219, rs796053220, rs796053228, rs796052653, rs759584387, rs796052650, rs796052641, rs796052626, rs796052623, rs796052663, rs796052615, rs796052802, rs797044999, rs797045047, rs797045942, rs797045941, rs118192212, rs797044938, rs777257591, rs864321712, rs879255652, rs886039268, rs886039517, rs886039529, rs199497486, rs886039496, rs886039903, rs886041300, rs769827124, rs886041339, rs886041591, rs587783092, rs1555850151, rs1057516123, rs1057516121, rs1057516115, rs1057516111, rs1057516106, rs1057516105, rs756921902, rs1057516089, rs1057516087, rs1057516080, rs1057516076, rs1060499544, rs1555850512, rs1057517919, rs118192231, rs1057520413, rs1060503101, rs1064796294, rs1064794981, rs1064794632, rs1064797245, rs1131691830, rs1131692231, rs1131691936, rs1554626549, rs1553579225, rs1553531385, rs121918736, rs1554898088, rs1553579282, rs763353895, rs1553463119, rs1554093891, rs77838305, rs1555408401, rs1554627439, rs1554097873, rs1555850403, rs1064794719, rs1315483224, rs1567134495, rs770187706, rs1057518555, rs1576983339, rs1574192005, rs1459374430, rs1586800133, rs1574641522, rs1572096837, rs1572630269, rs1574554892, rs1574556643, rs1574571769, rs1574641605, rs1574697769, rs1574716524, rs1574746733, rs1574746935, rs1574752700, rs1574754680, rs863225030, rs1601545088, rs1600714727, rs1371059392, rs1600767259, rs1339542565, rs1600785769, rs2065899210, rs1600732174, rs1162306056, rs879255709, rs1900111672, rs2066910297, rs1554122080, rs796052941, rs1600789325, rs2082695884, rs1737677036, rs1737495759, rs868389022, rs1737685202, rs1737672350, rs762737130

Unknown
Disease name	Disease term	dbSNP ID	References
Endometrioma	Endometrioma		20864642
Endometriosis	Endometriosis	rs1800629, rs1143634	20864642