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RNPEP (arginyl aminopeptidase)

Gene

6051

Arginyl aminopeptidase

RNPEP

AP-B, APB

1q32.1

Show/Hide all(118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045299	hsa-miR-186-5p	CLASH	23622248
MIRT1314340	hsa-miR-1184	CLIP-seq
MIRT1314341	hsa-miR-1254	CLIP-seq
MIRT1314342	hsa-miR-153	CLIP-seq
MIRT1314343	hsa-miR-185	CLIP-seq
MIRT1314344	hsa-miR-1910	CLIP-seq
MIRT1314345	hsa-miR-3116	CLIP-seq
MIRT1314346	hsa-miR-3137	CLIP-seq
MIRT1314347	hsa-miR-3163	CLIP-seq
MIRT1314348	hsa-miR-3175	CLIP-seq
MIRT1314349	hsa-miR-3183	CLIP-seq
MIRT1314350	hsa-miR-3909	CLIP-seq
MIRT1314351	hsa-miR-4254	CLIP-seq
MIRT1314352	hsa-miR-4306	CLIP-seq
MIRT1314353	hsa-miR-4311	CLIP-seq
MIRT1314354	hsa-miR-4436b-5p	CLIP-seq
MIRT1314355	hsa-miR-448	CLIP-seq
MIRT1314356	hsa-miR-451b	CLIP-seq
MIRT1314357	hsa-miR-455-3p	CLIP-seq
MIRT1314358	hsa-miR-4644	CLIP-seq
MIRT1314359	hsa-miR-4668-3p	CLIP-seq
MIRT1314360	hsa-miR-4706	CLIP-seq
MIRT1314361	hsa-miR-4711-5p	CLIP-seq
MIRT1314362	hsa-miR-4723-3p	CLIP-seq
MIRT1314363	hsa-miR-4749-5p	CLIP-seq
MIRT1314364	hsa-miR-4766-5p	CLIP-seq
MIRT1314365	hsa-miR-4778-3p	CLIP-seq
MIRT1314366	hsa-miR-4778-5p	CLIP-seq
MIRT1314367	hsa-miR-4781-5p	CLIP-seq
MIRT1314368	hsa-miR-545	CLIP-seq
MIRT1314369	hsa-miR-944	CLIP-seq
MIRT2093513	hsa-miR-2117	CLIP-seq
MIRT2093514	hsa-miR-24	CLIP-seq
MIRT2093515	hsa-miR-3120-5p	CLIP-seq
MIRT1314346	hsa-miR-3137	CLIP-seq
MIRT1314348	hsa-miR-3175	CLIP-seq
MIRT2093516	hsa-miR-3976	CLIP-seq
MIRT2093517	hsa-miR-4265	CLIP-seq
MIRT2093518	hsa-miR-4283	CLIP-seq
MIRT2093519	hsa-miR-4296	CLIP-seq
MIRT2093520	hsa-miR-4322	CLIP-seq
MIRT2093521	hsa-miR-4417	CLIP-seq
MIRT2093522	hsa-miR-4437	CLIP-seq
MIRT2093523	hsa-miR-4508	CLIP-seq
MIRT1314360	hsa-miR-4706	CLIP-seq
MIRT2093524	hsa-miR-4736	CLIP-seq
MIRT1314363	hsa-miR-4749-5p	CLIP-seq
MIRT1314367	hsa-miR-4781-5p	CLIP-seq
MIRT2093525	hsa-miR-657	CLIP-seq
MIRT2318061	hsa-miR-1202	CLIP-seq
MIRT2318062	hsa-miR-129-3p	CLIP-seq
MIRT1314342	hsa-miR-153	CLIP-seq
MIRT2318063	hsa-miR-3121-5p	CLIP-seq
MIRT1314347	hsa-miR-3163	CLIP-seq
MIRT2318064	hsa-miR-3184	CLIP-seq
MIRT2318065	hsa-miR-3194-5p	CLIP-seq
MIRT2318066	hsa-miR-383	CLIP-seq
MIRT2318067	hsa-miR-3972	CLIP-seq
MIRT2318068	hsa-miR-423-5p	CLIP-seq
MIRT2318069	hsa-miR-4270	CLIP-seq
MIRT2318070	hsa-miR-4441	CLIP-seq
MIRT1314355	hsa-miR-448	CLIP-seq
MIRT1314359	hsa-miR-4668-3p	CLIP-seq
MIRT1314361	hsa-miR-4711-5p	CLIP-seq
MIRT2318071	hsa-miR-4772-5p	CLIP-seq
MIRT2318072	hsa-miR-508-5p	CLIP-seq
MIRT2318073	hsa-miR-665	CLIP-seq
MIRT2613793	hsa-miR-1200	CLIP-seq
MIRT1314341	hsa-miR-1254	CLIP-seq
MIRT2613794	hsa-miR-1292	CLIP-seq
MIRT1314345	hsa-miR-3116	CLIP-seq
MIRT2613795	hsa-miR-3122	CLIP-seq
MIRT2613796	hsa-miR-3123	CLIP-seq
MIRT2318064	hsa-miR-3184	CLIP-seq
MIRT2318066	hsa-miR-383	CLIP-seq
MIRT2613797	hsa-miR-3913-5p	CLIP-seq
MIRT2613798	hsa-miR-3925-5p	CLIP-seq
MIRT2318068	hsa-miR-423-5p	CLIP-seq
MIRT1314351	hsa-miR-4254	CLIP-seq
MIRT2318069	hsa-miR-4270	CLIP-seq
MIRT2613799	hsa-miR-4324	CLIP-seq
MIRT2318070	hsa-miR-4441	CLIP-seq
MIRT2613800	hsa-miR-4471	CLIP-seq
MIRT1314364	hsa-miR-4766-5p	CLIP-seq
MIRT2318071	hsa-miR-4772-5p	CLIP-seq
MIRT1314366	hsa-miR-4778-5p	CLIP-seq
MIRT2613801	hsa-miR-495	CLIP-seq
MIRT2318072	hsa-miR-508-5p	CLIP-seq
MIRT2613802	hsa-miR-544b	CLIP-seq
MIRT2318073	hsa-miR-665	CLIP-seq
MIRT1314369	hsa-miR-944	CLIP-seq
MIRT2613793	hsa-miR-1200	CLIP-seq
MIRT1314341	hsa-miR-1254	CLIP-seq
MIRT2613794	hsa-miR-1292	CLIP-seq
MIRT1314343	hsa-miR-185	CLIP-seq
MIRT1314345	hsa-miR-3116	CLIP-seq
MIRT2613795	hsa-miR-3122	CLIP-seq
MIRT2613796	hsa-miR-3123	CLIP-seq
MIRT2318064	hsa-miR-3184	CLIP-seq
MIRT2318066	hsa-miR-383	CLIP-seq
MIRT2613797	hsa-miR-3913-5p	CLIP-seq
MIRT2613798	hsa-miR-3925-5p	CLIP-seq
MIRT2318068	hsa-miR-423-5p	CLIP-seq
MIRT1314351	hsa-miR-4254	CLIP-seq
MIRT2318069	hsa-miR-4270	CLIP-seq
MIRT1314352	hsa-miR-4306	CLIP-seq
MIRT2613799	hsa-miR-4324	CLIP-seq
MIRT2318070	hsa-miR-4441	CLIP-seq
MIRT2613800	hsa-miR-4471	CLIP-seq
MIRT1314358	hsa-miR-4644	CLIP-seq
MIRT1314364	hsa-miR-4766-5p	CLIP-seq
MIRT2318071	hsa-miR-4772-5p	CLIP-seq
MIRT1314366	hsa-miR-4778-5p	CLIP-seq
MIRT2613801	hsa-miR-495	CLIP-seq
MIRT2318072	hsa-miR-508-5p	CLIP-seq
MIRT2613802	hsa-miR-544b	CLIP-seq
MIRT2318073	hsa-miR-665	CLIP-seq
MIRT1314369	hsa-miR-944	CLIP-seq

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004177	Function	Aminopeptidase activity	ISS	9405297
GO:0004177	Function	Aminopeptidase activity	NAS	12119107
GO:0004301	Function	Epoxide hydrolase activity	NAS	12119107
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	ISS	9405297
GO:0005576	Component	Extracellular region	TAS	10467730
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005886	Component	Plasma membrane	ISS	9405297
GO:0005886	Component	Plasma membrane	TAS	10467730
GO:0006508	Process	Proteolysis	IBA	21873635
GO:0006508	Process	Proteolysis	IC	12119107
GO:0008235	Function	Metalloexopeptidase activity	NAS	12119107
GO:0008270	Function	Zinc ion binding	NAS	12119107
GO:0070006	Function	Metalloaminopeptidase activity	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145

MIM	HGNC	e!Ensembl
602675	10078	ENSG00000176393

Protein

UniProt ID

Q9H4A4

Protein name

Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase)

Protein function

Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17900	Peptidase_M1_N	37 → 230		Domain
PF01433	Peptidase_M1	261 → 482	Peptidase family M1 domain	Domain
PF09127	Leuk-A4-hydro_C	530 → 645	Leukotriene A4 hydrolase, C-terminal	Family

Sequence

MASGEHSPGSGAARRPLHSAQAVDVASASNFRAFELLHLHLDLRAEFGPPGPGAGSRGLS
GTAVLDLRCLEPEGAAELRLDSHPCLEVTAAALRRERPGSEEPPAEPVSFYTQPFSHYGQ
ALCVSFPQPCRAAERLQVLLTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFP
CFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRGPNKFFFQMCQPIPSYLIALAIGDLVS
AEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGM
ENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRIST
ILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCF
VSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFD
RWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDMKAIEAVAISPWKTYQLVYFLD
KILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGK
QKYTLPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAPKGS

Sequence length

650

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	26634245

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