FASTKD5 (FAST kinase domains 5)

Gene

• Entrez ID: 60493
• Gene name: FAST kinase domains 5
• Gene symbol: FASTKD5
• Synonyms: dJ1187M17.5
• Chromosome: 20
• Chromosome location: 20p13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050449	hsa-miR-23a-3p	CLASH	23622248
MIRT989759	hsa-miR-1261	CLIP-seq
MIRT989760	hsa-miR-128	CLIP-seq
MIRT989761	hsa-miR-149	CLIP-seq
MIRT989762	hsa-miR-181a	CLIP-seq
MIRT989763	hsa-miR-181b	CLIP-seq
MIRT989764	hsa-miR-181c	CLIP-seq
MIRT989765	hsa-miR-181d	CLIP-seq
MIRT989766	hsa-miR-27a	CLIP-seq
MIRT989767	hsa-miR-27b	CLIP-seq
MIRT989768	hsa-miR-3064-5p	CLIP-seq
MIRT989769	hsa-miR-3119	CLIP-seq
MIRT989770	hsa-miR-323-3p	CLIP-seq
MIRT989771	hsa-miR-374a	CLIP-seq
MIRT989772	hsa-miR-374b	CLIP-seq
MIRT989773	hsa-miR-4262	CLIP-seq
MIRT989774	hsa-miR-4312	CLIP-seq
MIRT989775	hsa-miR-450b-5p	CLIP-seq
MIRT989776	hsa-miR-4661-5p	CLIP-seq
MIRT989777	hsa-miR-4666-3p	CLIP-seq
MIRT989778	hsa-miR-4704-5p	CLIP-seq
MIRT989779	hsa-miR-4794	CLIP-seq
MIRT989780	hsa-miR-4803	CLIP-seq
MIRT989781	hsa-miR-490-3p	CLIP-seq
MIRT989782	hsa-miR-507	CLIP-seq
MIRT989783	hsa-miR-513a-5p	CLIP-seq
MIRT989784	hsa-miR-557	CLIP-seq
MIRT989785	hsa-miR-649	CLIP-seq
MIRT989786	hsa-miR-802	CLIP-seq
MIRT989760	hsa-miR-128	CLIP-seq
MIRT989766	hsa-miR-27a	CLIP-seq
MIRT989767	hsa-miR-27b	CLIP-seq
MIRT989770	hsa-miR-323-3p	CLIP-seq
MIRT989776	hsa-miR-4661-5p	CLIP-seq
MIRT1993335	hsa-miR-4699-3p	CLIP-seq
MIRT989778	hsa-miR-4704-5p	CLIP-seq
MIRT1993336	hsa-miR-4795-3p	CLIP-seq
MIRT989780	hsa-miR-4803	CLIP-seq
MIRT989781	hsa-miR-490-3p	CLIP-seq
MIRT989783	hsa-miR-513a-5p	CLIP-seq
MIRT989785	hsa-miR-649	CLIP-seq
MIRT989786	hsa-miR-802	CLIP-seq
MIRT989760	hsa-miR-128	CLIP-seq
MIRT989766	hsa-miR-27a	CLIP-seq
MIRT989767	hsa-miR-27b	CLIP-seq
MIRT989770	hsa-miR-323-3p	CLIP-seq
MIRT989776	hsa-miR-4661-5p	CLIP-seq
MIRT989778	hsa-miR-4704-5p	CLIP-seq
MIRT989780	hsa-miR-4803	CLIP-seq
MIRT989781	hsa-miR-490-3p	CLIP-seq
MIRT989783	hsa-miR-513a-5p	CLIP-seq
MIRT989785	hsa-miR-649	CLIP-seq
MIRT989786	hsa-miR-802	CLIP-seq
MIRT2531133	hsa-miR-101	CLIP-seq
MIRT989759	hsa-miR-1261	CLIP-seq
MIRT2531134	hsa-miR-1264	CLIP-seq
MIRT2531135	hsa-miR-144	CLIP-seq
MIRT989761	hsa-miR-149	CLIP-seq
MIRT989762	hsa-miR-181a	CLIP-seq
MIRT989763	hsa-miR-181b	CLIP-seq
MIRT989764	hsa-miR-181c	CLIP-seq
MIRT989765	hsa-miR-181d	CLIP-seq
MIRT989768	hsa-miR-3064-5p	CLIP-seq
MIRT989769	hsa-miR-3119	CLIP-seq
MIRT989771	hsa-miR-374a	CLIP-seq
MIRT989772	hsa-miR-374b	CLIP-seq
MIRT989773	hsa-miR-4262	CLIP-seq
MIRT2531136	hsa-miR-4279	CLIP-seq
MIRT989774	hsa-miR-4312	CLIP-seq
MIRT989775	hsa-miR-450b-5p	CLIP-seq
MIRT989776	hsa-miR-4661-5p	CLIP-seq
MIRT989777	hsa-miR-4666-3p	CLIP-seq
MIRT989778	hsa-miR-4704-5p	CLIP-seq
MIRT2531137	hsa-miR-4789-5p	CLIP-seq
MIRT989779	hsa-miR-4794	CLIP-seq
MIRT989781	hsa-miR-490-3p	CLIP-seq
MIRT989782	hsa-miR-507	CLIP-seq
MIRT989784	hsa-miR-557	CLIP-seq
MIRT2531138	hsa-miR-603	CLIP-seq
MIRT989785	hsa-miR-649	CLIP-seq
MIRT2531133	hsa-miR-101	CLIP-seq
MIRT989759	hsa-miR-1261	CLIP-seq
MIRT2531134	hsa-miR-1264	CLIP-seq
MIRT2531135	hsa-miR-144	CLIP-seq
MIRT989761	hsa-miR-149	CLIP-seq
MIRT989762	hsa-miR-181a	CLIP-seq
MIRT989763	hsa-miR-181b	CLIP-seq
MIRT989764	hsa-miR-181c	CLIP-seq
MIRT989765	hsa-miR-181d	CLIP-seq
MIRT989768	hsa-miR-3064-5p	CLIP-seq
MIRT989769	hsa-miR-3119	CLIP-seq
MIRT989771	hsa-miR-374a	CLIP-seq
MIRT989772	hsa-miR-374b	CLIP-seq
MIRT989773	hsa-miR-4262	CLIP-seq
MIRT2531136	hsa-miR-4279	CLIP-seq
MIRT989774	hsa-miR-4312	CLIP-seq
MIRT989775	hsa-miR-450b-5p	CLIP-seq
MIRT989776	hsa-miR-4661-5p	CLIP-seq
MIRT989777	hsa-miR-4666-3p	CLIP-seq
MIRT989778	hsa-miR-4704-5p	CLIP-seq
MIRT989779	hsa-miR-4794	CLIP-seq
MIRT989781	hsa-miR-490-3p	CLIP-seq
MIRT989782	hsa-miR-507	CLIP-seq
MIRT989784	hsa-miR-557	CLIP-seq
MIRT2531138	hsa-miR-603	CLIP-seq
MIRT989785	hsa-miR-649	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000963	Process	Mitochondrial RNA processing	IMP	25683715
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	25416956, 30126976, 32296183, 32814053
GO:0005739	Component	Mitochondrion	IDA	20869947
GO:0006397	Process	MRNA processing	IEA
GO:0019843	Function	RRNA binding	IDA	25683715
GO:0035770	Component	Ribonucleoprotein granule	IDA	25683715
GO:0042645	Component	Mitochondrial nucleoid	IDA	25683715
GO:0044528	Process	Regulation of mitochondrial mRNA stability	IEA

Other IDs

• MIM: 614272
• HGNC: 25790
• e!Ensembl: ENSG00000215251

Protein

• UniProt ID: Q7L8L6
• Protein name: FAST kinase domain-containing protein 5, mitochondrial
• Protein function: Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06743	FAST_1	431 → 500	FAST kinase-like protein, subdomain 1	Family
  PF08368	FAST_2	511 → 602	FAST kinase-like protein, subdomain 2	Family
  PF08373	RAP	699 → 758	RAP domain	Domain

• Sequence:

  MAATLKSLKLVRYRAFCSPSAFGAVRSVSYWNVSSTQHGGQDPPEHISLCHSAKKVKNIC
  STFSSRRILTTSSAHPGLEFSKTSSSKASTLQLGSPRATGVDEEDVEVFDSFENMRVFLQ
  LRPEYRVHSYNASETSQLLSVSEGELILHKVRVNQNNLQAQVIVDYLCKLSSLPAEQHPV
  LLGSTSFALLCQLSVKKIQLFDTQDLINVLKAFVILGIPHSHSMLDVYETKCCHQVWEMN
  MDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIGENRQVSQDLMQ
  KLESLILKYIDLINLEEVGTICLGFFKSSTNLSEFVMRKIGDLACANIQHLSSRSLVNIV
  KMFRFTHVDHINFMKQIGEIAPQRIPSLGVQGVMHLTLYCSALRFLNEGVMNAVAASLPP
  RVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLISEIHRKMPEFNQYPEHLPTCLLGLA
  FLEYFPVELIDFALSPGFVRLAQERTKFDLLKELYTLDGTVGIECPDYRGNRLSTHLQQE
  GSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQYVKHHMILPHTRSSDLEVQLDVNLKP
  LPFNREATPAENVAKLRLEHVGVSLTDDLMNKLLKGKARGHFQGKTESEPGQQPMELENK
  AAVPLGGFLCNVADKSGAMEMAGLCPAACMQTPRMKLAVQFTNRNQYCYGSRDLLGLHNM
  KRRQLARLGYRVVELSYWEWLPLLKRTRLEKLAFLHEKVFTSAL

• Sequence length: 764

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21822266