MRPS35 (mitochondrial ribosomal protein S35)

Gene

• Entrez ID: 60488
• Gene name: Mitochondrial ribosomal protein S35
• Gene symbol: MRPS35
• Synonyms: HDCMD11P, MDS023, MRP-S28, MRPS28, mS35
• Chromosome: 12
• Chromosome location: 12p11.22
• Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT032029	hsa-miR-16-5p	Proteomics	18668040
MIRT048361	hsa-miR-29b-3p	CLASH	23622248
MIRT042657	hsa-miR-196b-5p	CLASH	23622248
MIRT039244	hsa-miR-454-3p	CLASH	23622248
MIRT656170	hsa-miR-15b-3p	HITS-CLIP	23824327
MIRT656170	hsa-miR-15b-3p	HITS-CLIP	23824327
MIRT656170	hsa-miR-15b-3p	HITS-CLIP	23824327
MIRT656170	hsa-miR-15b-3p	HITS-CLIP	23824327
MIRT1160409	hsa-miR-1200	CLIP-seq
MIRT1160410	hsa-miR-1305	CLIP-seq
MIRT1160411	hsa-miR-3074-5p	CLIP-seq
MIRT1160412	hsa-miR-3126-5p	CLIP-seq
MIRT1160413	hsa-miR-3143	CLIP-seq
MIRT1160414	hsa-miR-3148	CLIP-seq
MIRT1160415	hsa-miR-3160-3p	CLIP-seq
MIRT1160416	hsa-miR-34b	CLIP-seq
MIRT1160417	hsa-miR-3662	CLIP-seq
MIRT1160418	hsa-miR-3688-5p	CLIP-seq
MIRT1160419	hsa-miR-3915	CLIP-seq
MIRT1160420	hsa-miR-3921	CLIP-seq
MIRT1160421	hsa-miR-3928	CLIP-seq
MIRT1160422	hsa-miR-4324	CLIP-seq
MIRT1160423	hsa-miR-4419a	CLIP-seq
MIRT1160424	hsa-miR-4487	CLIP-seq
MIRT1160425	hsa-miR-4510	CLIP-seq
MIRT1160426	hsa-miR-4633-5p	CLIP-seq
MIRT1160427	hsa-miR-4649-3p	CLIP-seq
MIRT1160428	hsa-miR-4653-5p	CLIP-seq
MIRT1160429	hsa-miR-4714-5p	CLIP-seq
MIRT1160430	hsa-miR-4764-3p	CLIP-seq
MIRT1160431	hsa-miR-4775	CLIP-seq
MIRT1160432	hsa-miR-4795-5p	CLIP-seq
MIRT1160433	hsa-miR-532-5p	CLIP-seq
MIRT1160434	hsa-miR-543	CLIP-seq
MIRT1160435	hsa-miR-544b	CLIP-seq
MIRT1160436	hsa-miR-558	CLIP-seq
MIRT1160437	hsa-miR-590-3p	CLIP-seq
MIRT1160438	hsa-miR-618	CLIP-seq
MIRT2046114	hsa-miR-1202	CLIP-seq
MIRT2046115	hsa-miR-181a	CLIP-seq
MIRT2046116	hsa-miR-181b	CLIP-seq
MIRT2046117	hsa-miR-181c	CLIP-seq
MIRT2046118	hsa-miR-181d	CLIP-seq
MIRT2046119	hsa-miR-1909	CLIP-seq
MIRT2046120	hsa-miR-1915	CLIP-seq
MIRT2046121	hsa-miR-203	CLIP-seq
MIRT2046122	hsa-miR-2116	CLIP-seq
MIRT2046123	hsa-miR-219-2-3p	CLIP-seq
MIRT2046124	hsa-miR-221	CLIP-seq
MIRT2046125	hsa-miR-222	CLIP-seq
MIRT2046126	hsa-miR-2277-3p	CLIP-seq
MIRT2046127	hsa-miR-2964a-3p	CLIP-seq
MIRT2046128	hsa-miR-3145-5p	CLIP-seq
MIRT2046129	hsa-miR-3168	CLIP-seq
MIRT2046130	hsa-miR-3194-5p	CLIP-seq
MIRT2046131	hsa-miR-3972	CLIP-seq
MIRT2046132	hsa-miR-4262	CLIP-seq
MIRT2046133	hsa-miR-4275	CLIP-seq
MIRT1160426	hsa-miR-4633-5p	CLIP-seq
MIRT2046134	hsa-miR-4680-3p	CLIP-seq
MIRT2046135	hsa-miR-4724-5p	CLIP-seq
MIRT2046136	hsa-miR-4726-3p	CLIP-seq
MIRT2046137	hsa-miR-4758-3p	CLIP-seq
MIRT2046138	hsa-miR-4761-5p	CLIP-seq
MIRT1160431	hsa-miR-4775	CLIP-seq
MIRT1160432	hsa-miR-4795-5p	CLIP-seq
MIRT2046139	hsa-miR-508-5p	CLIP-seq
MIRT1160433	hsa-miR-532-5p	CLIP-seq
MIRT2046140	hsa-miR-548c-3p	CLIP-seq
MIRT2046141	hsa-miR-550b	CLIP-seq
MIRT1160437	hsa-miR-590-3p	CLIP-seq
MIRT2046142	hsa-miR-606	CLIP-seq
MIRT2046143	hsa-miR-668	CLIP-seq
MIRT1160409	hsa-miR-1200	CLIP-seq
MIRT2275155	hsa-miR-1225-3p	CLIP-seq
MIRT2275156	hsa-miR-1233	CLIP-seq
MIRT2275157	hsa-miR-1265	CLIP-seq
MIRT2275158	hsa-miR-1291	CLIP-seq
MIRT1160410	hsa-miR-1305	CLIP-seq
MIRT2275159	hsa-miR-1323	CLIP-seq
MIRT2046115	hsa-miR-181a	CLIP-seq
MIRT2046116	hsa-miR-181b	CLIP-seq
MIRT2046117	hsa-miR-181c	CLIP-seq
MIRT2046118	hsa-miR-181d	CLIP-seq
MIRT2275160	hsa-miR-1912	CLIP-seq
MIRT2046121	hsa-miR-203	CLIP-seq
MIRT2275161	hsa-miR-216a	CLIP-seq
MIRT2275162	hsa-miR-216b	CLIP-seq
MIRT2275163	hsa-miR-2392	CLIP-seq
MIRT1160411	hsa-miR-3074-5p	CLIP-seq
MIRT2275164	hsa-miR-3128	CLIP-seq
MIRT1160413	hsa-miR-3143	CLIP-seq
MIRT2046128	hsa-miR-3145-5p	CLIP-seq
MIRT1160415	hsa-miR-3160-3p	CLIP-seq
MIRT2275165	hsa-miR-3163	CLIP-seq
MIRT2275166	hsa-miR-328	CLIP-seq
MIRT1160417	hsa-miR-3662	CLIP-seq
MIRT2275167	hsa-miR-3668	CLIP-seq
MIRT2275168	hsa-miR-3684	CLIP-seq
MIRT1160418	hsa-miR-3688-5p	CLIP-seq
MIRT2275169	hsa-miR-3924	CLIP-seq
MIRT2046132	hsa-miR-4262	CLIP-seq
MIRT2275170	hsa-miR-4272	CLIP-seq
MIRT2046133	hsa-miR-4275	CLIP-seq
MIRT2275171	hsa-miR-4323	CLIP-seq
MIRT1160422	hsa-miR-4324	CLIP-seq
MIRT2275172	hsa-miR-4436b-5p	CLIP-seq
MIRT2275173	hsa-miR-4470	CLIP-seq
MIRT1160424	hsa-miR-4487	CLIP-seq
MIRT1160426	hsa-miR-4633-5p	CLIP-seq
MIRT2275174	hsa-miR-4660	CLIP-seq
MIRT2275175	hsa-miR-4668-3p	CLIP-seq
MIRT2275176	hsa-miR-4698	CLIP-seq
MIRT2046135	hsa-miR-4724-5p	CLIP-seq
MIRT2046137	hsa-miR-4758-3p	CLIP-seq
MIRT2046138	hsa-miR-4761-5p	CLIP-seq
MIRT2275177	hsa-miR-486-3p	CLIP-seq
MIRT2046139	hsa-miR-508-5p	CLIP-seq
MIRT1160433	hsa-miR-532-5p	CLIP-seq
MIRT1160434	hsa-miR-543	CLIP-seq
MIRT1160435	hsa-miR-544b	CLIP-seq
MIRT2275178	hsa-miR-548o	CLIP-seq
MIRT2046141	hsa-miR-550b	CLIP-seq
MIRT1160436	hsa-miR-558	CLIP-seq
MIRT2275179	hsa-miR-582-3p	CLIP-seq
MIRT1160437	hsa-miR-590-3p	CLIP-seq
MIRT2046142	hsa-miR-606	CLIP-seq
MIRT2046143	hsa-miR-668	CLIP-seq
MIRT2275180	hsa-miR-885-3p	CLIP-seq
MIRT2275168	hsa-miR-3684	CLIP-seq
MIRT2465665	hsa-miR-3919	CLIP-seq
MIRT2465666	hsa-miR-4756-3p	CLIP-seq
MIRT2046114	hsa-miR-1202	CLIP-seq
MIRT2275159	hsa-miR-1323	CLIP-seq
MIRT2046121	hsa-miR-203	CLIP-seq
MIRT2574174	hsa-miR-2110	CLIP-seq
MIRT2574175	hsa-miR-3151	CLIP-seq
MIRT2574176	hsa-miR-3153	CLIP-seq
MIRT2275165	hsa-miR-3163	CLIP-seq
MIRT2046130	hsa-miR-3194-5p	CLIP-seq
MIRT2275167	hsa-miR-3668	CLIP-seq
MIRT2275169	hsa-miR-3924	CLIP-seq
MIRT2046131	hsa-miR-3972	CLIP-seq
MIRT2574177	hsa-miR-4265	CLIP-seq
MIRT2574178	hsa-miR-4271	CLIP-seq
MIRT2574179	hsa-miR-4274	CLIP-seq
MIRT2574180	hsa-miR-4296	CLIP-seq
MIRT2574181	hsa-miR-4305	CLIP-seq
MIRT2574182	hsa-miR-4322	CLIP-seq
MIRT2574183	hsa-miR-4447	CLIP-seq
MIRT2574184	hsa-miR-4472	CLIP-seq
MIRT2275175	hsa-miR-4668-3p	CLIP-seq
MIRT2574185	hsa-miR-4668-5p	CLIP-seq
MIRT2574186	hsa-miR-4711-5p	CLIP-seq
MIRT2574187	hsa-miR-4725-3p	CLIP-seq
MIRT2574188	hsa-miR-491-5p	CLIP-seq
MIRT2275178	hsa-miR-548o	CLIP-seq
MIRT2046114	hsa-miR-1202	CLIP-seq
MIRT2046121	hsa-miR-203	CLIP-seq
MIRT2574174	hsa-miR-2110	CLIP-seq
MIRT2574175	hsa-miR-3151	CLIP-seq
MIRT2574176	hsa-miR-3153	CLIP-seq
MIRT2275165	hsa-miR-3163	CLIP-seq
MIRT2046130	hsa-miR-3194-5p	CLIP-seq
MIRT2275167	hsa-miR-3668	CLIP-seq
MIRT2275169	hsa-miR-3924	CLIP-seq
MIRT2046131	hsa-miR-3972	CLIP-seq
MIRT2574177	hsa-miR-4265	CLIP-seq
MIRT2574178	hsa-miR-4271	CLIP-seq
MIRT2574180	hsa-miR-4296	CLIP-seq
MIRT2574181	hsa-miR-4305	CLIP-seq
MIRT2574182	hsa-miR-4322	CLIP-seq
MIRT2574183	hsa-miR-4447	CLIP-seq
MIRT2574184	hsa-miR-4472	CLIP-seq
MIRT2275175	hsa-miR-4668-3p	CLIP-seq
MIRT2574185	hsa-miR-4668-5p	CLIP-seq
MIRT2574186	hsa-miR-4711-5p	CLIP-seq
MIRT2574187	hsa-miR-4725-3p	CLIP-seq
MIRT2574188	hsa-miR-491-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005763	Component	Mitochondrial small ribosomal subunit	IBA	21873635
GO:0005763	Component	Mitochondrial small ribosomal subunit	ISS
GO:0005763	Component	Mitochondrial small ribosomal subunit	NAS	11279123
GO:0042769	Process	DNA damage response, detection of DNA damage	NAS	15300802
GO:0070125	Process	Mitochondrial translational elongation	TAS
GO:0070126	Process	Mitochondrial translational termination	TAS

Other IDs

• MIM: 611995
• HGNC: 16635
• e!Ensembl: ENSG00000061794

Protein

• UniProt ID: P82673
• Protein name: Small ribosomal subunit protein mS35 (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt)
• PDB: 3J9M, 6NU2, 6NU3, 6RW4, 6RW5, 6VLZ, 6VMI, 6ZM5, 6ZM6, 6ZS9, 6ZSA, 6ZSB, 6ZSC, 6ZSD, 6ZSE, 6ZSG, 7A5F, 7A5G, 7A5I, 7A5K, 7L08, 7OG4, 7P2E, 7PNX, 7PNY, 7PNZ, 7PO0, 7PO1, 7PO2, 7PO3, 7QI4, 7QI5, 7QI6, 8ANY, 8CSP, 8CSQ, 8CSR, 8CSS, 8CST, 8CSU, 8K2A, 8OIR, 8OIS, 8QRK, 8QRL, 8QRM, 8QRN, 8RRI, 8XT0, 8XT2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10213	MRP-S28	141 → 267	Mitochondrial ribosomal subunit protein	Family

• Sequence:

  MAAAALPAWLSLQSRARTLRAFSTAVYSATPVPTPSLPERTPGNERPPRRKALPPRTEKM
  AVDQDWPSVYPVAAPFKPSAVPLPVRMGYPVKKGVPMAKEGNLELLKIPNFLHLTPVAIK
  KHCEALKDFCTEWPAALDSDEKCEKHFPIEIDSTDYVSSGPSVRNPRARVVVLRVKLSSL
  NLDDHAKKKLIKLVGERYCKTTDVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWE
  KSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINKEELLGTKEIEEYKKSVVSLK
  NEEENENSISQYKESVKRLLNVT

• Sequence length: 323

Pathways

Reactome:

Mitochondrial translation elongation
Mitochondrial translation termination

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	29632382, 23945395