BCL6 (BCL6 transcription repressor)

Gene

• Entrez ID: 604
• Gene name: BCL6 transcription repressor
• Gene symbol: BCL6
• Synonyms: BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
• Chromosome: 3
• Chromosome location: 3q27.3
• Summary: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 resp

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000640	hsa-miR-9-5p	Luciferase reporter assay	19956200
MIRT004463	hsa-miR-127-3p	Luciferase reporter assay	17581274
MIRT004463	hsa-miR-127-3p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	16766263
MIRT004463	hsa-miR-127-3p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	16766263
MIRT005929	hsa-miR-339-5p	qRT-PCR	20932331
MIRT006324	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT006324	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT006324	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT006324	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT006324	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT006324	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT006927	hsa-miR-155-5p	Luciferase reporter assay	23041630
MIRT006927	hsa-miR-155-5p	Luciferase reporter assay	23041630
MIRT017492	hsa-miR-335-5p	Microarray	18185580
MIRT022507	hsa-miR-124-3p	Microarray	18668037
MIRT035524	hsa-miR-21-5p	Luciferase reporter assay	23416424
MIRT035524	hsa-miR-21-5p	Luciferase reporter assay	23416424
MIRT054375	hsa-miR-205-5p	Luciferase reporter assay, Western blot	22870299
MIRT054375	hsa-miR-205-5p	Luciferase reporter assay, Western blot	22870299
MIRT005929	hsa-miR-339-5p	Immunohistochemistry, Luciferase reporter assay, Western blot	24917186
MIRT731339	hsa-miR-187-3p	Luciferase reporter assay	26845350
MIRT731339	hsa-miR-187-3p	Luciferase reporter assay	26845350
MIRT731339	hsa-miR-187-3p	Luciferase reporter assay	27073562
MIRT732380	hsa-miR-544a	Luciferase reporter assay, qRT-PCR, Western blot	27186677
MIRT732380	hsa-miR-544a	Luciferase reporter assay, qRT-PCR, Western blot	27186677
MIRT006927	hsa-miR-155-5p	qRT-PCR, Western blot	26986233
MIRT006927	hsa-miR-155-5p	qRT-PCR, Western blot	26986233
MIRT006927	hsa-miR-155-5p	qRT-PCR, Western blot	26986233
MIRT006927	hsa-miR-155-5p	qRT-PCR, Western blot	26986233
MIRT734457	hsa-miR-101-3p	Luciferase reporter assay, Western blotting, RNA-seq, qRT-PCR, In situ hybridization	31903129
MIRT735771	hsa-miR-139-3p	Luciferase reporter assay, qRT-PCR	32277518
MIRT735771	hsa-miR-139-3p	Luciferase reporter assay, qRT-PCR	32277518
MIRT735800	hsa-miR-1247-5p	Western blotting, qRT-PCR	33425899
MIRT736975	hsa-miR-144-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR, Flow cytometry	32206063
MIRT755806	miR?144?3p	Luciferase reporter assay, Western blotting, qRT-PCR	34504602
MIRT006324	hsa-miR-30b-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35100079
MIRT819383	hsa-miR-101	CLIP-seq
MIRT819384	hsa-miR-106a	CLIP-seq
MIRT819385	hsa-miR-106b	CLIP-seq
MIRT819386	hsa-miR-10a	CLIP-seq
MIRT819387	hsa-miR-10b	CLIP-seq
MIRT819388	hsa-miR-1197	CLIP-seq
MIRT819389	hsa-miR-1203	CLIP-seq
MIRT819390	hsa-miR-1224-5p	CLIP-seq
MIRT819391	hsa-miR-1225-5p	CLIP-seq
MIRT819392	hsa-miR-124	CLIP-seq
MIRT819393	hsa-miR-1244	CLIP-seq
MIRT819394	hsa-miR-1255a	CLIP-seq
MIRT819395	hsa-miR-1255b	CLIP-seq
MIRT819396	hsa-miR-129-5p	CLIP-seq
MIRT819397	hsa-miR-144	CLIP-seq
MIRT819398	hsa-miR-17	CLIP-seq
MIRT819399	hsa-miR-20a	CLIP-seq
MIRT819400	hsa-miR-20b	CLIP-seq
MIRT819401	hsa-miR-3121-5p	CLIP-seq
MIRT819402	hsa-miR-3140-3p	CLIP-seq
MIRT819403	hsa-miR-329	CLIP-seq
MIRT819404	hsa-miR-3609	CLIP-seq
MIRT819405	hsa-miR-3613-5p	CLIP-seq
MIRT819406	hsa-miR-362-3p	CLIP-seq
MIRT819407	hsa-miR-362-5p	CLIP-seq
MIRT819408	hsa-miR-3681	CLIP-seq
MIRT819409	hsa-miR-3691-5p	CLIP-seq
MIRT819410	hsa-miR-374c	CLIP-seq
MIRT819411	hsa-miR-3941	CLIP-seq
MIRT819412	hsa-miR-4325	CLIP-seq
MIRT819413	hsa-miR-4421	CLIP-seq
MIRT819414	hsa-miR-4731-3p	CLIP-seq
MIRT819415	hsa-miR-4751	CLIP-seq
MIRT819416	hsa-miR-4796-3p	CLIP-seq
MIRT819417	hsa-miR-4801	CLIP-seq
MIRT819418	hsa-miR-500b	CLIP-seq
MIRT819419	hsa-miR-501-5p	CLIP-seq
MIRT819420	hsa-miR-506	CLIP-seq
MIRT819421	hsa-miR-507	CLIP-seq
MIRT819422	hsa-miR-519d	CLIP-seq
MIRT819423	hsa-miR-548ah	CLIP-seq
MIRT819424	hsa-miR-548an	CLIP-seq
MIRT819425	hsa-miR-557	CLIP-seq
MIRT819426	hsa-miR-582-5p	CLIP-seq
MIRT819427	hsa-miR-603	CLIP-seq
MIRT819428	hsa-miR-628-5p	CLIP-seq
MIRT819429	hsa-miR-655	CLIP-seq
MIRT819430	hsa-miR-93	CLIP-seq
MIRT1942121	hsa-miR-1275	CLIP-seq
MIRT1942122	hsa-miR-153	CLIP-seq
MIRT1942123	hsa-miR-187	CLIP-seq
MIRT1942124	hsa-miR-3158-5p	CLIP-seq
MIRT1942125	hsa-miR-331-3p	CLIP-seq
MIRT1942126	hsa-miR-4288	CLIP-seq
MIRT1942127	hsa-miR-4300	CLIP-seq
MIRT1942128	hsa-miR-4447	CLIP-seq
MIRT1942129	hsa-miR-4464	CLIP-seq
MIRT1942130	hsa-miR-4472	CLIP-seq
MIRT1942131	hsa-miR-448	CLIP-seq
MIRT1942132	hsa-miR-450b-5p	CLIP-seq
MIRT1942133	hsa-miR-4525	CLIP-seq
MIRT1942134	hsa-miR-4665-5p	CLIP-seq
MIRT1942135	hsa-miR-4716-3p	CLIP-seq
MIRT1942136	hsa-miR-4723-5p	CLIP-seq
MIRT1942137	hsa-miR-4728-5p	CLIP-seq
MIRT1942138	hsa-miR-4748	CLIP-seq
MIRT1942139	hsa-miR-4763-5p	CLIP-seq
MIRT1942140	hsa-miR-489	CLIP-seq
MIRT819421	hsa-miR-507	CLIP-seq
MIRT1942141	hsa-miR-514	CLIP-seq
MIRT1942142	hsa-miR-514b-3p	CLIP-seq
MIRT819425	hsa-miR-557	CLIP-seq
MIRT1942143	hsa-miR-558	CLIP-seq
MIRT1942144	hsa-miR-625	CLIP-seq
MIRT1942145	hsa-miR-632	CLIP-seq
MIRT1942146	hsa-miR-920	CLIP-seq
MIRT1942147	hsa-miR-939	CLIP-seq
MIRT819388	hsa-miR-1197	CLIP-seq
MIRT819390	hsa-miR-1224-5p	CLIP-seq
MIRT819392	hsa-miR-124	CLIP-seq
MIRT1942122	hsa-miR-153	CLIP-seq
MIRT2180997	hsa-miR-300	CLIP-seq
MIRT2180998	hsa-miR-3613-3p	CLIP-seq
MIRT819405	hsa-miR-3613-5p	CLIP-seq
MIRT2180999	hsa-miR-381	CLIP-seq
MIRT1942126	hsa-miR-4288	CLIP-seq
MIRT1942131	hsa-miR-448	CLIP-seq
MIRT1942132	hsa-miR-450b-5p	CLIP-seq
MIRT2181000	hsa-miR-4666-3p	CLIP-seq
MIRT819415	hsa-miR-4751	CLIP-seq
MIRT819420	hsa-miR-506	CLIP-seq
MIRT819421	hsa-miR-507	CLIP-seq
MIRT819424	hsa-miR-548an	CLIP-seq
MIRT819425	hsa-miR-557	CLIP-seq
MIRT1942145	hsa-miR-632	CLIP-seq
MIRT819388	hsa-miR-1197	CLIP-seq
MIRT819390	hsa-miR-1224-5p	CLIP-seq
MIRT819392	hsa-miR-124	CLIP-seq
MIRT819405	hsa-miR-3613-5p	CLIP-seq
MIRT819415	hsa-miR-4751	CLIP-seq
MIRT819420	hsa-miR-506	CLIP-seq
MIRT819424	hsa-miR-548an	CLIP-seq
MIRT2484362	hsa-miR-1253	CLIP-seq
MIRT2484363	hsa-miR-183	CLIP-seq
MIRT2484364	hsa-miR-3185	CLIP-seq
MIRT2484365	hsa-miR-34a	CLIP-seq
MIRT2484366	hsa-miR-34c-5p	CLIP-seq
MIRT819411	hsa-miR-3941	CLIP-seq
MIRT2484367	hsa-miR-3942-5p	CLIP-seq
MIRT2484368	hsa-miR-409-3p	CLIP-seq
MIRT2484369	hsa-miR-4307	CLIP-seq
MIRT2484370	hsa-miR-4434	CLIP-seq
MIRT2484371	hsa-miR-449a	CLIP-seq
MIRT2484372	hsa-miR-449b	CLIP-seq
MIRT2484373	hsa-miR-4516	CLIP-seq
MIRT2484374	hsa-miR-4517	CLIP-seq
MIRT2484375	hsa-miR-4643	CLIP-seq
MIRT2484376	hsa-miR-466	CLIP-seq
MIRT2484377	hsa-miR-4672	CLIP-seq
MIRT2484378	hsa-miR-4703-5p	CLIP-seq
MIRT2484379	hsa-miR-4789-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ABL1	Repression	15509806
BCL6	Repression	12407182
CTCF	Repression	20733034
FOSL2	Activation	22493372
FOXO3	Activation	15509806
FOXO4	Activation	11777915
IRF4	Repression	17785200
JUND	Activation	22493372
JUND	Repression	18071306
MEF2B	Unknown	23974956
SPI1	Repression	19564417
STAT3	Activation	20228272;23716595
STAT5	Repression	23716595
STAT5A	Repression	16819511
STAT5B	Repression	16819511
ZEB1	Repression	20175752

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	11929873, 15577913
GO:0000902	Process	Cell morphogenesis	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0001161	Function	Intronic transcription regulatory region sequence-specific DNA binding	IEA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA	21873635
GO:0001817	Process	Regulation of cytokine production	IBA	21873635
GO:0001953	Process	Negative regulation of cell-matrix adhesion	IEA
GO:0002467	Process	Germinal center formation	IEA
GO:0002634	Process	Regulation of germinal center formation	NAS	7795255
GO:0002682	Process	Regulation of immune system process	IBA	21873635
GO:0002903	Process	Negative regulation of B cell apoptotic process	NAS	15577913
GO:0003682	Function	Chromatin binding	IDA	12097386
GO:0003700	Function	DNA-binding transcription factor activity	IMP	15577913
GO:0005515	Function	Protein binding	IPI	10898795, 12590135, 16147992, 16819511, 21390126, 22113614, 25416956, 27107012, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	7795255, 10898795, 11929873
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005657	Component	Replication fork	IDA	10490843
GO:0005730	Component	Nucleolus	IDA
GO:0005794	Component	Golgi apparatus	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006954	Process	Inflammatory response	IEA
GO:0006974	Process	Cellular response to DNA damage stimulus	IDA	15577913
GO:0007266	Process	Rho protein signal transduction	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0008104	Process	Protein localization	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030183	Process	B cell differentiation	IEA
GO:0030308	Process	Negative regulation of cell growth	IDA	10490843
GO:0030890	Process	Positive regulation of B cell proliferation	IEA
GO:0031065	Process	Positive regulation of histone deacetylation	IEA
GO:0031490	Function	Chromatin DNA binding	IEA
GO:0032764	Process	Negative regulation of mast cell cytokine production	IEA
GO:0035024	Process	Negative regulation of Rho protein signal transduction	IEA
GO:0042092	Process	Type 2 immune response	IBA	21873635
GO:0042127	Process	Regulation of cell population proliferation	IBA	21873635
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0042981	Process	Regulation of apoptotic process	TAS
GO:0043065	Process	Positive regulation of apoptotic process	IDA	10490843
GO:0043087	Process	Regulation of GTPase activity	IEA
GO:0043380	Process	Regulation of memory T cell differentiation	IEA
GO:0043565	Function	Sequence-specific DNA binding	IDA	15577913
GO:0045591	Process	Positive regulation of regulatory T cell differentiation	IMP	20935202, 22387553
GO:0045595	Process	Regulation of cell differentiation	IBA	21873635
GO:0045629	Process	Negative regulation of T-helper 2 cell differentiation	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0045746	Process	Negative regulation of Notch signaling pathway	IEA
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IMP	15577913
GO:0045892	Process	Negative regulation of transcription, DNA-templated	NAS	9135990
GO:0046872	Function	Metal ion binding	IEA
GO:0048294	Process	Negative regulation of isotype switching to IgE isotypes	IEA
GO:0048821	Process	Erythrocyte development	IEA
GO:0050727	Process	Regulation of inflammatory response	IBA	21873635
GO:0050776	Process	Regulation of immune response	NAS	16455075
GO:0051272	Process	Positive regulation of cellular component movement	IEA
GO:1903464	Process	Negative regulation of mitotic cell cycle DNA replication	NAS	10490843
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000773	Process	Negative regulation of cellular senescence	IEA

Other IDs

• MIM: 109565
• HGNC: 1001
• e!Ensembl: ENSG00000113916

Protein

• UniProt ID: P41182
• Protein name: B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51)
• Protein function: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors
• PDB: 1R28, 1R29, 1R2B, 2EN2, 2EOS, 2LCE, 2YRM, 3BIM, 3E4U, 3LBZ, 4CP3, 4U2M, 5H7G, 5H7H, 5MW2, 5MW6, 5MWD, 5N1X, 5N1Z, 5N20, 5N21, 5X4M, 5X4N, 5X4O, 5X4P, 5X4Q, 5X9O, 5X9P, 6C3L, 6C3N, 6CQ1, 6EW6, 6EW7, 6EW8, 6TBT, 6TCJ, 6TOF, 6TOG, 6TOH, 6TOI, 6TOJ, 6TOK, 6TOL, 6TOM, 6TON, 6TOO, 6XMX, 6XWF, 6XXS, 6XYX, 6XZZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00651	BTB	22 → 129	BTB/POZ domain	Domain
  PF00096	zf-C2H2	546 → 568	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	574 → 596	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	602 → 624	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	630 → 652	Zinc finger, C2H2 type	Domain

• Sequence:

  MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSI
  FTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDT
  CRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAF
  APSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPG
  EYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKAS
  KEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASG
  SPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEP
  ENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGS
  QSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQT
  HSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEK
  PYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHC
  EKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC

• Sequence length: 706

Pathways

KEGG:

FoxO signaling pathway
Transcriptional misregulation in cancer
Chemical carcinogenesis - receptor activation

Reactome:

Interleukin-4 and Interleukin-13 signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
FOXO-mediated transcription of cell death genes

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diffuse lymphoma	Diffuse Mixed-Cell Lymphoma	rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291	25543051
Follicular lymphoma	Follicular lymphoma	rs587776632, rs587776633, rs587776634, rs587776635, rs587776636, rs587776637
Lymphoma	Lymphoma, Lymphoma, Follicular, Lymphoma, Mixed-Cell, Lymphoma, Undifferentiated, Lymphoma, Small Noncleaved-Cell, Lymphoma, Diffuse, Lymphoma, Non-Hodgkin, Familial	rs11540652, rs1592119138, rs1592123162, rs1599367044	22968395, 25543051
Non-hodgkin lymphoma	Lymphoma, Non-Hodgkin	rs121908689, rs28936699, rs121909775, rs398122800, rs121913357, rs121913355, rs398122820	25543051

Unknown
Disease name	Disease term	dbSNP ID	References
Angioendotheliomatosis	Angioendotheliomatosis
B-cell lymphoma	Mediastinal (Thymic) Large B-Cell Lymphoma		17116487
High grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement	High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement
Intravascular large b-cell lymphoma	Intravascular large B-cell lymphoma
Lymphocytic leukemia	Chronic Lymphocytic Leukemia
High grade lymphoma	High Grade Lymphoma (neoplasm)		25543051
Intermediate grade lymphoma	Lymphoma, Intermediate-Grade		25543051
Low grade lymphoma	Low Grade Lymphoma (neoplasm)		25543051
Mediastinal lymphadenopathy	Mediastinal lymphadenopathy
Pleural effusion	Pleural effusion disorder
Mediastinal b-cell lymphoma	Primary mediastinal large B-cell lymphoma
Reticulosarcoma	Reticulosarcoma		25543051
T-cell lymphoma	T-Cell Lymphoma		15375218