RNASE4 (ribonuclease A family member 4)

Gene

• Entrez ID: 6038
• Gene name: Ribonuclease A family member 4
• Gene symbol: RNASE4
• Synonyms: RAB1, RNS4
• Chromosome: 14
• Chromosome location: 14q11.2
• Summary: The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3` side of uridine nucleotides. Alternative splicing results in four transcript variants enc

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017156	hsa-miR-335-5p	Microarray	18185580
MIRT024338	hsa-miR-215-5p	Microarray	19074876
MIRT026275	hsa-miR-192-5p	Microarray	19074876
MIRT1308614	hsa-miR-3148	CLIP-seq
MIRT1308615	hsa-miR-3647-3p	CLIP-seq
MIRT1308616	hsa-miR-3973	CLIP-seq
MIRT1308617	hsa-miR-5095	CLIP-seq
MIRT1308618	hsa-miR-520g	CLIP-seq
MIRT1308619	hsa-miR-520h	CLIP-seq
MIRT1308620	hsa-miR-552	CLIP-seq
MIRT1308621	hsa-miR-556-3p	CLIP-seq
MIRT1308622	hsa-miR-561	CLIP-seq
MIRT1308623	hsa-miR-664	CLIP-seq
MIRT1308624	hsa-miR-873	CLIP-seq
MIRT1308625	hsa-miR-136	CLIP-seq
MIRT1308626	hsa-miR-3675-3p	CLIP-seq
MIRT1308617	hsa-miR-5095	CLIP-seq
MIRT1308620	hsa-miR-552	CLIP-seq
MIRT1308627	hsa-miR-654-3p	CLIP-seq
MIRT2612220	hsa-miR-302a	CLIP-seq
MIRT2612221	hsa-miR-302b	CLIP-seq
MIRT2612222	hsa-miR-302c	CLIP-seq
MIRT2612223	hsa-miR-302d	CLIP-seq
MIRT2612224	hsa-miR-302e	CLIP-seq
MIRT2612225	hsa-miR-372	CLIP-seq
MIRT2612226	hsa-miR-373	CLIP-seq
MIRT2612227	hsa-miR-3913-3p	CLIP-seq
MIRT2612228	hsa-miR-4528	CLIP-seq
MIRT2612229	hsa-miR-4536	CLIP-seq
MIRT2612230	hsa-miR-489	CLIP-seq
MIRT2612231	hsa-miR-512-3p	CLIP-seq
MIRT2612232	hsa-miR-519a	CLIP-seq
MIRT2612233	hsa-miR-519b-3p	CLIP-seq
MIRT2612234	hsa-miR-519c-3p	CLIP-seq
MIRT2612235	hsa-miR-520a-3p	CLIP-seq
MIRT2612236	hsa-miR-520b	CLIP-seq
MIRT2612237	hsa-miR-520c-3p	CLIP-seq
MIRT2612238	hsa-miR-520d-3p	CLIP-seq
MIRT2612239	hsa-miR-520e	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0004522	Function	Ribonuclease A activity	NAS	7742370
GO:0004540	Function	Ribonuclease activity	IBA	21873635
GO:0004540	Function	Ribonuclease activity	IDA	3467790
GO:0005576	Component	Extracellular region	IDA	3467790
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	3467790
GO:0006379	Process	MRNA cleavage	NAS	7742370
GO:0090501	Process	RNA phosphodiester bond hydrolysis	IDA	3467790
GO:0090502	Process	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA

Other IDs

• MIM: 601030
• HGNC: 10047
• e!Ensembl: ENSG00000258818

Protein

• UniProt ID: P34096
• Protein name: Ribonuclease 4 (RNase 4) (EC 3.1.27.-)
• Protein function: Cleaves preferentially after uridine bases (PubMed:3467790). Has antimicrobial activity against uropathogenic E.coli (UPEC) (PubMed:33818125). Probably contributes to urinary tract sterility (PubMed:33818125). {ECO:0000269|PubMed:33818125, ECO:0
• PDB: 1RNF, 2RNF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00074	RnaseA	31 → 146	Pancreatic ribonuclease	Domain

• Sequence:

  MALQRTHSLLLLLLLTLLGLGLVQPSYGQDGMYQRFLRQHVHPEETGGSDRYCNLMMQRR
  KMTLYHCKRFNTFIHEDIWNIRSICSTTNIQCKNGKMNCHEGVVKVTDCRDTGSSRAPNC
  RYRAIASTRRVVIACEGNPQVPVHFDG

• Sequence length: 147

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis 9	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs1885090126, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs749428135, rs371575563, rs1402429085, rs1218712729, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881