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RLN2 (relaxin 2)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6019
Gene nameGene Name - the full gene name approved by the HGNC.
Relaxin 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
RLN2
SynonymsGene synonyms aliases
H2, H2-RLX, RLXH2, bA12D24.1.1, bA12D24.1.2
ChromosomeChromosome number
9
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9p24.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT609113 hsa-miR-8084 HITS-CLIP 24906430
MIRT609112 hsa-miR-7153-3p HITS-CLIP 24906430
MIRT571257 hsa-miR-1255a HITS-CLIP 24906430
MIRT571256 hsa-miR-1255b-5p HITS-CLIP 24906430
MIRT609111 hsa-miR-4789-5p HITS-CLIP 24906430
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
NR3C1 Unknown 15149733
PGR Unknown 15149733
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IEA
GO:0005576 Component Extracellular region TAS
GO:0007186 Process G protein-coupled receptor signaling pathway TAS
GO:0007565 Process Female pregnancy TAS 6548702
GO:0010628 Process Positive regulation of gene expression IDA 11459784
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P04090
Protein name Prorelaxin H2 [Cleaved into: Relaxin B chain; Relaxin A chain]
Protein function Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
PDB 2MV1 , 6RLX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00049 Insulin
32 → 185
Insulin/IGF/Relaxin family
 Domain
Sequence
Sequence length 185
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Neuroactive ligand-receptor interaction
Relaxin signaling pathway 		  G alpha (s) signalling events
Relaxin receptors
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 16434975
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 16434975

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