RGS12 (regulator of G protein signaling 12)

Gene

• Entrez ID: 6002
• Gene name: Regulator of G protein signaling 12
• Gene symbol: RGS12
• Synonyms: -
• Chromosome: 4
• Chromosome location: 4p16.3
• Summary: This gene encodes a member of the `regulator of G protein signaling` (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumo

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045830	hsa-miR-138-5p	CLASH	23622248
MIRT045473	hsa-miR-149-5p	CLASH	23622248
MIRT716003	hsa-miR-4459	HITS-CLIP	19536157
MIRT716002	hsa-miR-665	HITS-CLIP	19536157
MIRT716001	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT716000	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT715999	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT715998	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT715997	hsa-miR-4532	HITS-CLIP	19536157
MIRT715996	hsa-miR-7704	HITS-CLIP	19536157
MIRT716003	hsa-miR-4459	HITS-CLIP	19536157
MIRT716002	hsa-miR-665	HITS-CLIP	19536157
MIRT716001	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT716000	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT715999	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT715998	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT715997	hsa-miR-4532	HITS-CLIP	19536157
MIRT715996	hsa-miR-7704	HITS-CLIP	19536157
MIRT1304102	hsa-miR-1197	CLIP-seq
MIRT1304103	hsa-miR-1266	CLIP-seq
MIRT1304104	hsa-miR-2467-3p	CLIP-seq
MIRT1304105	hsa-miR-3158-5p	CLIP-seq
MIRT1304106	hsa-miR-335	CLIP-seq
MIRT1304107	hsa-miR-3612	CLIP-seq
MIRT1304108	hsa-miR-365	CLIP-seq
MIRT1304109	hsa-miR-3664-3p	CLIP-seq
MIRT1304110	hsa-miR-3678-3p	CLIP-seq
MIRT1304111	hsa-miR-3680	CLIP-seq
MIRT1304112	hsa-miR-377	CLIP-seq
MIRT1304113	hsa-miR-4420	CLIP-seq
MIRT1304114	hsa-miR-4436a	CLIP-seq
MIRT1304115	hsa-miR-4443	CLIP-seq
MIRT1304116	hsa-miR-4518	CLIP-seq
MIRT1304117	hsa-miR-4651	CLIP-seq
MIRT1304118	hsa-miR-4696	CLIP-seq
MIRT1304119	hsa-miR-4733-3p	CLIP-seq
MIRT1304120	hsa-miR-4793-5p	CLIP-seq
MIRT1304121	hsa-miR-485-5p	CLIP-seq
MIRT1304122	hsa-miR-539	CLIP-seq
MIRT1304123	hsa-miR-580	CLIP-seq
MIRT1304124	hsa-miR-608	CLIP-seq
MIRT1304125	hsa-miR-650	CLIP-seq
MIRT1304126	hsa-miR-759	CLIP-seq
MIRT2314892	hsa-miR-3690	CLIP-seq
MIRT2314893	hsa-miR-4254	CLIP-seq
MIRT2314894	hsa-miR-4310	CLIP-seq
MIRT1304120	hsa-miR-4793-5p	CLIP-seq
MIRT2314895	hsa-miR-626	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000794	Component	Condensed nuclear chromosome	TAS	10869340
GO:0003924	Function	GTPase activity	TAS
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	9651375
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0016363	Component	Nuclear matrix	IEA
GO:0030425	Component	Dendrite	ISS
GO:0030695	Function	GTPase regulator activity	IDA	9651375
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0045202	Component	Synapse	ISS

Other IDs

• MIM: 602512
• HGNC: 9994
• e!Ensembl: ENSG00000159788

Protein

• UniProt ID: O14924
• Protein name: Regulator of G-protein signaling 12 (RGS12)
• Protein function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. ; FUNCTI
• PDB: 2EBZ, 2KV8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00595	PDZ	22 → 96	PDZ domain	Domain
  PF00615	RGS	715 → 831	Regulator of G protein signaling domain	Domain
  PF16613	RGS12_us1	836 → 953		Disordered
  PF02196	RBD	963 → 1030	Raf-like Ras-binding domain	Domain
  PF02196	RBD	1034 → 1102	Raf-like Ras-binding domain	Domain
  PF16611	RGS12_us2	1106 → 1180		Disordered
  PF02188	GoLoco	1188 → 1209	GoLoco motif	Motif
  PF16612	RGS12_usC	1239 → 1376		Disordered

• Sequence:

  MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRA
  GDQILAVNEINVKKASHEDVVKLIGKCSGVLHMVIAEGVGRFESCSSDEEGGLYEGKGWL
  KPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASNSEPLKLKQRSLSESAATRFD
  VGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDDFALDASILNVAMIVGYLGSIEL
  PSTSSNLESDSLQAIRGCMRRLRAEQKIHSLVTMKIMHDCVQLSTDKAGVVAEYPAEKLA
  FSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALRTSCHVFMVDPDLFNHKIHQGIARRFG
  FECTADPDTNGCLEFPASSLPVLQFISVLYRDMGELIEGMRARAFLDGDADAHQNNSTSS
  NSDSGIGNFHQEEKSNRVLVVDLGGSSSRHGPGGSAWDGVGGRGAQPWGAPWTGPFCPDP
  EGSPPFEAAHQTDRFWDLNKHLGPASPVEVPPASLRSSVPPSKRGTVGAGCGFNQRWLPV
  HVLREWQCGHTSDQDSYTDSTDGWSSINCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKR
  EWSRKAFGMQSIFGPHRNVRKTKEDKKGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITR
  SLDDLESATVSDGELTGADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLL
  QDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATT
  PVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRA
  LPDSQQVPSSPASKHSLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSW
  SRTRSTGRSQKKREHGDHADDALHANGGLCRRESQGSVSSAGSLDLSEACRTLAPEKDKA
  TKHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSS
  ILESRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSG
  EKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNTAVNSSSRNHSATGEE
  RTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSN
  RADDQRGLLRKEDLVLPEFLRLPPGSTELTLPTPAAVAKGFSKRSATGNGRESASQPGEQ
  WEPVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSPVSLAQEGTAQIWKRQ
  SQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTPQEVPGPSRPGSGTHGSRD
  LPVNRIIDVDLVTGSAPGRDGGIAGAQAGPGRSQASGGPPTSDLPGLGPVPGEPAKPKTS
  AHHATFV

• Sequence length: 1447

Pathways

Reactome:

G alpha (i) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Myocardial infarction	Myocardial Infarction	rs12316150, rs41303970, rs909253, rs7291467, rs2234693	21211798
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21822266

Unknown
Disease name	Disease term	dbSNP ID	References
Huntington disease	Huntington Disease	rs768047421	22387017