Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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5987 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Tripartite motif containing 27 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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TRIM27 |
SynonymsGene synonyms aliases
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RFP, RNF76 |
ChromosomeChromosome number
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6 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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6p22.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
IDA |
10976108 |
GO:0000209 |
Process |
Protein polyubiquitination |
IBA |
21873635 |
GO:0001650 |
Component |
Fibrillar center |
IDA |
|
GO:0002820 |
Process |
Negative regulation of adaptive immune response |
IMP |
22128329 |
GO:0003676 |
Function |
Nucleic acid binding |
TAS |
3380101 |
GO:0003677 |
Function |
DNA binding |
IEA |
|
GO:0003713 |
Function |
Transcription coactivator activity |
IDA |
23077300 |
GO:0004842 |
Function |
Ubiquitin-protein transferase activity |
IDA |
22128329 |
GO:0004842 |
Function |
Ubiquitin-protein transferase activity |
IMP |
23452853 |
GO:0005515 |
Function |
Protein binding |
IPI |
9570750, 10504338, 15837424, 16189514, 21516116, 22128329, 22829933, 23452853, 24722188, 25416956, 25910212, 26871637, 27107012, 29892012, 31515488, 32296183, 32814053 |
GO:0005634 |
Component |
Nucleus |
IDA |
17156811 |
GO:0005654 |
Component |
Nucleoplasm |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
10976108 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
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GO:0005730 |
Component |
Nucleolus |
IDA |
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GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
17156811 |
GO:0005768 |
Component |
Endosome |
IDA |
23452853 |
GO:0005769 |
Component |
Early endosome |
IEA |
|
GO:0005829 |
Component |
Cytosol |
IBA |
21873635 |
GO:0005829 |
Component |
Cytosol |
TAS |
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GO:0006469 |
Process |
Negative regulation of protein kinase activity |
IDA |
22128329 |
GO:0007283 |
Process |
Spermatogenesis |
TAS |
3380101 |
GO:0008270 |
Function |
Zinc ion binding |
IEA |
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GO:0010468 |
Process |
Regulation of gene expression |
IBA |
21873635 |
GO:0010508 |
Process |
Positive regulation of autophagy |
IBA |
21873635 |
GO:0016567 |
Process |
Protein ubiquitination |
IBA |
21873635 |
GO:0016605 |
Component |
PML body |
IEA |
|
GO:0019901 |
Function |
Protein kinase binding |
IBA |
21873635 |
GO:0030904 |
Component |
Retromer complex |
IDA |
23452853 |
GO:0031965 |
Component |
Nuclear membrane |
IDA |
10976108 |
GO:0032609 |
Process |
Interferon-gamma production |
IMP |
22128329 |
GO:0032703 |
Process |
Negative regulation of interleukin-2 production |
IMP |
22128329 |
GO:0032720 |
Process |
Negative regulation of tumor necrosis factor production |
IMP |
22128329 |
GO:0032880 |
Process |
Regulation of protein localization |
IBA |
21873635 |
GO:0032897 |
Process |
Negative regulation of viral transcription |
IBA |
21873635 |
GO:0032897 |
Process |
Negative regulation of viral transcription |
IDA |
18248090 |
GO:0034314 |
Process |
Arp2/3 complex-mediated actin nucleation |
IDA |
23452853 |
GO:0042147 |
Process |
Retrograde transport, endosome to Golgi |
IDA |
23452853 |
GO:0042802 |
Function |
Identical protein binding |
IPI |
17156811, 22829933, 25416956, 27107012 |
GO:0042803 |
Function |
Protein homodimerization activity |
IBA |
21873635 |
GO:0043123 |
Process |
Positive regulation of I-kappaB kinase/NF-kappaB signaling |
IBA |
21873635 |
GO:0045087 |
Process |
Innate immune response |
IBA |
21873635 |
GO:0045087 |
Process |
Innate immune response |
IDA |
18248090 |
GO:0045814 |
Process |
Negative regulation of gene expression, epigenetic |
IDA |
10976108 |
GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IEA |
|
GO:0046596 |
Process |
Regulation of viral entry into host cell |
IBA |
21873635 |
GO:0046872 |
Function |
Metal ion binding |
TAS |
3380101 |
GO:0051091 |
Process |
Positive regulation of DNA-binding transcription factor activity |
IDA |
23077300 |
GO:0051092 |
Process |
Positive regulation of NF-kappaB transcription factor activity |
IBA |
21873635 |
GO:0061630 |
Function |
Ubiquitin protein ligase activity |
EXP |
23419514 |
GO:0061630 |
Function |
Ubiquitin protein ligase activity |
IBA |
21873635 |
GO:0070534 |
Process |
Protein K63-linked ubiquitination |
IBA |
21873635 |
GO:0070534 |
Process |
Protein K63-linked ubiquitination |
IMP |
23452853 |
GO:0090281 |
Process |
Negative regulation of calcium ion import |
IMP |
22128329 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
P14373 |
Protein name |
Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27) |
Protein function |
E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:22829933, PubMed:24144979, Pub |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF15227 |
zf-C3HC4_4 |
16 → 56 |
|
Domain |
PF00643 |
zf-B_box |
91 → 132 |
B-box zinc finger |
Domain |
PF13765 |
PRY |
318 → 366 |
SPRY-associated domain |
Family |
PF00622 |
SPRY |
370 → 487 |
SPRY domain |
Family |
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Sequence |
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Sequence length |
513 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Papillary thyroid carcinoma |
Papillary thyroid carcinoma |
rs751409106 |
12787916, 17062879 |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
30285260 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Thyroid carcinoma |
Differentiated thyroid carcinoma |
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