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TRIM27 (tripartite motif containing 27)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5987
Gene nameGene Name - the full gene name approved by the HGNC.
Tripartite motif containing 27
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TRIM27
SynonymsGene synonyms aliases
RFP, RNF76
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p22.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT039436 hsa-miR-421 CLASH 23622248
MIRT052686 hsa-miR-1260b CLASH 23622248
MIRT709741 hsa-miR-586 HITS-CLIP 19536157
MIRT709740 hsa-miR-6870-3p HITS-CLIP 19536157
MIRT709739 hsa-miR-942-5p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 10976108
GO:0000209 Process Protein polyubiquitination IBA 21873635
GO:0001650 Component Fibrillar center IDA
GO:0002820 Process Negative regulation of adaptive immune response IMP 22128329
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P14373
Protein name Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27)
Protein function E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:22829933, PubMed:24144979, Pub
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15227 zf-C3HC4_4
16 56
Domain
PF00643 zf-B_box
91 132
B-box zinc finger
Domain
PF13765 PRY
318 366
SPRY-associated domain
Family
PF00622 SPRY
370 487
SPRY domain
Family
Sequence
MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETF
PQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDR
SREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMERE
KIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQ
QQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQS
DMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCV
LGSPCF
IAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWAL
TSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSG
GKSAAPL
IICPMSGIDGFSGHVGNHGHSMETSP
Sequence length 513
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    SUMOylation of ubiquitinylation proteins
Regulation of PTEN stability and activity
Suppression of apoptosis
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Papillary thyroid carcinoma Papillary thyroid carcinoma rs751409106 12787916, 17062879
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 30285260
Unknown
Disease name Disease term dbSNP ID References
Thyroid carcinoma Differentiated thyroid carcinoma

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